Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness
Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a w...
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ftroysocietyfig:oai:figshare.com:article/16657091 2023-05-15T14:31:07+02:00 Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness Lukas Tietgen Ingerid J. Hagen Oddmund Kleven Cecilia Di Bernardi Thomas Kvalnes Karin Norén Malin Hasselgren Johan Fredrik Wallén Anders Angerbjörn Arild Landa Nina E. Eide Øystein Flagstad Henrik Jensen 2021-09-22T08:30:34Z https://doi.org/10.6084/m9.figshare.16657091.v1 https://figshare.com/articles/dataset/Supplementary_material_8_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657091 unknown doi:10.6084/m9.figshare.16657091.v1 https://figshare.com/articles/dataset/Supplementary_material_8_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657091 CC BY 4.0 CC-BY Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population Dataset 2021 ftroysocietyfig https://doi.org/10.6084/m9.figshare.16657091.v1 2022-01-01T19:08:00Z Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a wild non-model species. Using a whole-genome approach, we identified the MC1R gene as the sole causal gene underlying Arctic fox Vulpes lagopus fur colour. Further, we showed the adaptive importance of fur colour genotypes through measures of fitness that link ecological and evolutionary processes. We found a tendency for blue foxes that are heterozygous at the fur colour locus to have higher fitness than homozygous white foxes. The effect of genotype on fitness was independent of winter duration but varied with prey availability, with the strongest effect in years of increasing rodent populations. MC1R is located in a genomic region with high gene density, and we discuss the potential for indirect selection through linkage and pleiotropy. Our study shows that whole-genome analyses can be successfully applied to wild species and identify major effect genes underlying adaptive traits. Furthermore, we show how this approach can be used to identify knowledge gaps in our understanding of interactions between ecology and evolution. Dataset Arctic Fox Arctic Vulpes lagopus The Royal Society: Figshare Arctic |
institution |
Open Polar |
collection |
The Royal Society: Figshare |
op_collection_id |
ftroysocietyfig |
language |
unknown |
topic |
Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population |
spellingShingle |
Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population Lukas Tietgen Ingerid J. Hagen Oddmund Kleven Cecilia Di Bernardi Thomas Kvalnes Karin Norén Malin Hasselgren Johan Fredrik Wallén Anders Angerbjörn Arild Landa Nina E. Eide Øystein Flagstad Henrik Jensen Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
topic_facet |
Genetics Evolutionary Biology Ecology adaptive trait endangered species fitness estimation genome-wide association study indirect selection wild population |
description |
Genome-wide association studies provide good opportunities for studying the genetic basis of adaptive traits in wild populations. Yet, previous studies often failed to identify major effect genes. In this study, we used high-density single nucleotide polymorphism and individual fitness data from a wild non-model species. Using a whole-genome approach, we identified the MC1R gene as the sole causal gene underlying Arctic fox Vulpes lagopus fur colour. Further, we showed the adaptive importance of fur colour genotypes through measures of fitness that link ecological and evolutionary processes. We found a tendency for blue foxes that are heterozygous at the fur colour locus to have higher fitness than homozygous white foxes. The effect of genotype on fitness was independent of winter duration but varied with prey availability, with the strongest effect in years of increasing rodent populations. MC1R is located in a genomic region with high gene density, and we discuss the potential for indirect selection through linkage and pleiotropy. Our study shows that whole-genome analyses can be successfully applied to wild species and identify major effect genes underlying adaptive traits. Furthermore, we show how this approach can be used to identify knowledge gaps in our understanding of interactions between ecology and evolution. |
format |
Dataset |
author |
Lukas Tietgen Ingerid J. Hagen Oddmund Kleven Cecilia Di Bernardi Thomas Kvalnes Karin Norén Malin Hasselgren Johan Fredrik Wallén Anders Angerbjörn Arild Landa Nina E. Eide Øystein Flagstad Henrik Jensen |
author_facet |
Lukas Tietgen Ingerid J. Hagen Oddmund Kleven Cecilia Di Bernardi Thomas Kvalnes Karin Norén Malin Hasselgren Johan Fredrik Wallén Anders Angerbjörn Arild Landa Nina E. Eide Øystein Flagstad Henrik Jensen |
author_sort |
Lukas Tietgen |
title |
Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_short |
Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_full |
Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_fullStr |
Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_full_unstemmed |
Supplementary material 8 from Fur colour in the Arctic fox: genetic architecture and consequences for fitness |
title_sort |
supplementary material 8 from fur colour in the arctic fox: genetic architecture and consequences for fitness |
publishDate |
2021 |
url |
https://doi.org/10.6084/m9.figshare.16657091.v1 https://figshare.com/articles/dataset/Supplementary_material_8_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657091 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Fox Arctic Vulpes lagopus |
genre_facet |
Arctic Fox Arctic Vulpes lagopus |
op_relation |
doi:10.6084/m9.figshare.16657091.v1 https://figshare.com/articles/dataset/Supplementary_material_8_from_Fur_colour_in_the_Arctic_fox_genetic_architecture_and_consequences_for_fitness/16657091 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.16657091.v1 |
_version_ |
1766304837764382720 |