Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013
Enterovirus 71 (EV-71) is involved in epidemics of hand, foot, and mouth disease (HFMD) and has been reported to occur with severe neurological complications in eastern and south-east Asia. In other geographical areas, the transmission of this virus is poorly understood. We used large sequence datas...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Other Non-Article Part of Journal/Newspaper |
Language: | English |
Published: |
Robert Koch-Institut, Infektionskrankheiten / Erreger
2015
|
Subjects: | |
Online Access: | http://edoc.rki.de/oa/articles/re26le7BpF8UA/PDF/26OTMBISTyh7M.pdf http://edoc.rki.de/176904/2132 https://nbn-resolving.org/urn:nbn:de:0257-10040926 https://doi.org/10.25646/2057 |
id |
ftrobertkoch:oai:edoc.rki.de:176904/2132 |
---|---|
record_format |
openpolar |
spelling |
ftrobertkoch:oai:edoc.rki.de:176904/2132 2023-05-15T16:49:09+02:00 Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013 Hassel, C. Mirand, A. Lukashev, A. Terletskaia-Ladwig, E. Farkas, A. Schuffenecker, I. Diedrich, Sabine Huemer, H. P. Archimbaud, C. Peigue-Lafeuille, H. Henquell, C. Bailly, J. 2015-08-27 application/pdf http://edoc.rki.de/oa/articles/re26le7BpF8UA/PDF/26OTMBISTyh7M.pdf http://edoc.rki.de/176904/2132 https://nbn-resolving.org/urn:nbn:de:0257-10040926 https://doi.org/10.25646/2057 eng eng Robert Koch-Institut, Infektionskrankheiten / Erreger http://edoc.rki.de/oa/articles/re26le7BpF8UA/PDF/26OTMBISTyh7M.pdf http://edoc.rki.de/176904/2132 urn:nbn:de:0257-10040926 http://dx.doi.org/10.25646/2057 Humans Bayes Theorem Molecular Sequence Data Genotype Phylogeny Europe/epidemiology RNA Viral/genetics Polymorphism Genetic Disease Outbreaks Molecular Epidemiology European Union Sentinel Surveillance Geography Genes Viral Enterovirus Infections/epidemiology Enterovirus Infections/virology Enterovirus A Human/classification Enterovirus A Human/genetics Enterovirus A Human/isolation & purification Enterovirus Infections/transmission Iceland/epidemiology Norway/epidemiology Switzerland/epidemiology 610 Medizin ddc:610 periodicalPart doc-type:periodicalPart 2015 ftrobertkoch https://doi.org/10.25646/2057 2022-06-20T05:48:48Z Enterovirus 71 (EV-71) is involved in epidemics of hand, foot, and mouth disease (HFMD) and has been reported to occur with severe neurological complications in eastern and south-east Asia. In other geographical areas, the transmission of this virus is poorly understood. We used large sequence datasets (of the gene encoding the viral protein 1, VP1) and a Bayesian phylogenetic approach to compare the molecular epidemiology and geographical spread patterns of EV-71 subgenogroups B4, B5, C1, C2, and C4 in Europe relative to other parts of the world. For the study, European countries considered were European Union (EU) Member States and Iceland, Norway and Switzerland. Viruses of the B4, B5, and C4 subgenogroups circulate mainly in eastern and south-east Asia. In Europe sporadic introductions of these subgenogroups are observed, however C1 and C2 viruses predominate. The phylogenies showed evidence of multiple events of spread involving C1 and C2 viruses within Europe since the mid-1990s. Two waves of sporadic C2 infections also occurred in 2010 and 2013. The 2007 Dutch outbreak caused by C2 and the occurrence of B5 and C4 infections in the EU between 2004 and 2013 arose while the circulation of C1 viruses was low. A transmission chain involving a C4 virus was traced from Japan to the EU and then further to Canada between 2001 and 2006. Recent events whereby spread of viruses have occurred from, to, and within Europe appear to be involved in the long term survival of EV-71, highlighting the need for enhanced surveillance of this virus. Other Non-Article Part of Journal/Newspaper Iceland Robert Koch Institute: Publications Canada Norway |
institution |
Open Polar |
collection |
Robert Koch Institute: Publications |
op_collection_id |
ftrobertkoch |
language |
English |
topic |
Humans Bayes Theorem Molecular Sequence Data Genotype Phylogeny Europe/epidemiology RNA Viral/genetics Polymorphism Genetic Disease Outbreaks Molecular Epidemiology European Union Sentinel Surveillance Geography Genes Viral Enterovirus Infections/epidemiology Enterovirus Infections/virology Enterovirus A Human/classification Enterovirus A Human/genetics Enterovirus A Human/isolation & purification Enterovirus Infections/transmission Iceland/epidemiology Norway/epidemiology Switzerland/epidemiology 610 Medizin ddc:610 |
spellingShingle |
Humans Bayes Theorem Molecular Sequence Data Genotype Phylogeny Europe/epidemiology RNA Viral/genetics Polymorphism Genetic Disease Outbreaks Molecular Epidemiology European Union Sentinel Surveillance Geography Genes Viral Enterovirus Infections/epidemiology Enterovirus Infections/virology Enterovirus A Human/classification Enterovirus A Human/genetics Enterovirus A Human/isolation & purification Enterovirus Infections/transmission Iceland/epidemiology Norway/epidemiology Switzerland/epidemiology 610 Medizin ddc:610 Hassel, C. Mirand, A. Lukashev, A. Terletskaia-Ladwig, E. Farkas, A. Schuffenecker, I. Diedrich, Sabine Huemer, H. P. Archimbaud, C. Peigue-Lafeuille, H. Henquell, C. Bailly, J. Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013 |
topic_facet |
Humans Bayes Theorem Molecular Sequence Data Genotype Phylogeny Europe/epidemiology RNA Viral/genetics Polymorphism Genetic Disease Outbreaks Molecular Epidemiology European Union Sentinel Surveillance Geography Genes Viral Enterovirus Infections/epidemiology Enterovirus Infections/virology Enterovirus A Human/classification Enterovirus A Human/genetics Enterovirus A Human/isolation & purification Enterovirus Infections/transmission Iceland/epidemiology Norway/epidemiology Switzerland/epidemiology 610 Medizin ddc:610 |
description |
Enterovirus 71 (EV-71) is involved in epidemics of hand, foot, and mouth disease (HFMD) and has been reported to occur with severe neurological complications in eastern and south-east Asia. In other geographical areas, the transmission of this virus is poorly understood. We used large sequence datasets (of the gene encoding the viral protein 1, VP1) and a Bayesian phylogenetic approach to compare the molecular epidemiology and geographical spread patterns of EV-71 subgenogroups B4, B5, C1, C2, and C4 in Europe relative to other parts of the world. For the study, European countries considered were European Union (EU) Member States and Iceland, Norway and Switzerland. Viruses of the B4, B5, and C4 subgenogroups circulate mainly in eastern and south-east Asia. In Europe sporadic introductions of these subgenogroups are observed, however C1 and C2 viruses predominate. The phylogenies showed evidence of multiple events of spread involving C1 and C2 viruses within Europe since the mid-1990s. Two waves of sporadic C2 infections also occurred in 2010 and 2013. The 2007 Dutch outbreak caused by C2 and the occurrence of B5 and C4 infections in the EU between 2004 and 2013 arose while the circulation of C1 viruses was low. A transmission chain involving a C4 virus was traced from Japan to the EU and then further to Canada between 2001 and 2006. Recent events whereby spread of viruses have occurred from, to, and within Europe appear to be involved in the long term survival of EV-71, highlighting the need for enhanced surveillance of this virus. |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Hassel, C. Mirand, A. Lukashev, A. Terletskaia-Ladwig, E. Farkas, A. Schuffenecker, I. Diedrich, Sabine Huemer, H. P. Archimbaud, C. Peigue-Lafeuille, H. Henquell, C. Bailly, J. |
author_facet |
Hassel, C. Mirand, A. Lukashev, A. Terletskaia-Ladwig, E. Farkas, A. Schuffenecker, I. Diedrich, Sabine Huemer, H. P. Archimbaud, C. Peigue-Lafeuille, H. Henquell, C. Bailly, J. |
author_sort |
Hassel, C. |
title |
Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013 |
title_short |
Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013 |
title_full |
Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013 |
title_fullStr |
Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013 |
title_full_unstemmed |
Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013 |
title_sort |
transmission patterns of human enterovirus 71 to, from and among european countries, 2003 to 2013 |
publisher |
Robert Koch-Institut, Infektionskrankheiten / Erreger |
publishDate |
2015 |
url |
http://edoc.rki.de/oa/articles/re26le7BpF8UA/PDF/26OTMBISTyh7M.pdf http://edoc.rki.de/176904/2132 https://nbn-resolving.org/urn:nbn:de:0257-10040926 https://doi.org/10.25646/2057 |
geographic |
Canada Norway |
geographic_facet |
Canada Norway |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
http://edoc.rki.de/oa/articles/re26le7BpF8UA/PDF/26OTMBISTyh7M.pdf http://edoc.rki.de/176904/2132 urn:nbn:de:0257-10040926 http://dx.doi.org/10.25646/2057 |
op_doi |
https://doi.org/10.25646/2057 |
_version_ |
1766039256737775616 |