Geographical Distribution of Ljungan Virus in Small Mammals in Europe.
Ljungan virus (LV), which belongs to the Parechovirus genus in the Picornaviridae family, was first isolated from bank voles (Myodes glareolus) in Sweden in 1998 and proposed as a zoonotic agent. To improve knowledge of the host association and geographical distribution of LV, tissues from 1685 anim...
Published in: | Vector-Borne and Zoonotic Diseases |
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Online Access: | http://hdl.handle.net/10029/623873 https://doi.org/10.1089/vbz.2019.2542 |
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ftrivm:oai:rivm.openrepository.com:10029/623873 2023-05-15T18:40:37+02:00 Geographical Distribution of Ljungan Virus in Small Mammals in Europe. Fevola, Cristina Rossi, Chiara Rosso, Fausta Girardi, Matteo Rosà, Roberto Manica, Mattia Delucchi, Luca Rocchini, Duccio Garzon-Lopez, Carol X Arnoldi, Daniele Bianchi, Alessandro Buzan, Elena Charbonnel, Nathalie Collini, Margherita Ďureje, Ľudovít Ecke, Frauke Ferrari, Nicola Fischer, Stefan Gillingham, Emma L Hörnfeldt, Birger Kazimírová, Mária Konečný, Adam Maas, Miriam Magnusson, Magnus Miller, Andrea Niemimaa, Jukka Nordström, Åke Obiegala, Anna Olsson, Gert Pedrini, Paolo Piálek, Jaroslav Reusken, Chantal B Rizzolli, Franco Romeo, Claudia Silaghi, Cornelia Sironen, Tarja Stanko, Michal Tagliapietra, Valentina Ulrich, Rainer G Vapalahti, Olli Voutilainen, Liina Wauters, Lucas Rizzoli, Annapaola Vaheri, Antti Jääskeläinen, Anne J Henttonen, Heikki Hauffe, Heidi C 2020-06-02 http://hdl.handle.net/10029/623873 https://doi.org/10.1089/vbz.2019.2542 en eng 1557-7759 32487013 doi:10.1089/vbz.2019.2542 http://hdl.handle.net/10029/623873 Vector Borne Zoonotic Dis 2020; 20(9):692-702 Vector borne and zoonotic diseases (Larchmont, N.Y.) GLM Picornaviridae bank vole cartogram reservoir host rodent vector Article 2020 ftrivm https://doi.org/10.1089/vbz.2019.2542 2020-11-25T23:11:42Z Ljungan virus (LV), which belongs to the Parechovirus genus in the Picornaviridae family, was first isolated from bank voles (Myodes glareolus) in Sweden in 1998 and proposed as a zoonotic agent. To improve knowledge of the host association and geographical distribution of LV, tissues from 1685 animals belonging to multiple rodent and insectivore species from 12 European countries were screened for LV-RNA using reverse transcriptase (RT)-PCR. In addition, we investigated how the prevalence of LV-RNA in bank voles is associated with various intrinsic and extrinsic factors. We show that LV is widespread geographically, having been detected in at least one host species in nine European countries. Twelve out of 21 species screened were LV-RNA PCR positive, including, for the first time, the red vole (Myodes rutilus) and the root or tundra vole (Alexandromys formerly Microtus oeconomus), as well as in insectivores, including the bicolored white-toothed shrew (Crocidura leucodon) and the Valais shrew (Sorex antinorii). Results indicated that bank voles are the main rodent host for this virus (overall RT-PCR prevalence: 15.2%). Linear modeling of intrinsic and extrinsic factors that could impact LV prevalence showed a concave-down relationship between body mass and LV occurrence, so that subadults had the highest LV positivity, but LV in older animals was less prevalent. Also, LV prevalence was higher in autumn and lower in spring, and the amount of precipitation recorded during the 6 months preceding the trapping date was negatively correlated with the presence of the virus. Phylogenetic analysis on the 185 base pair species-specific sequence of the 5' untranslated region identified high genetic diversity (46.5%) between 80 haplotypes, although no geographical or host-specific patterns of diversity were detected. Article in Journal/Newspaper Tundra National Inst. for Public Health and the Environment, Netherlands (RIVM): Webbased Archive of RIVM Publications (WARP) Vector-Borne and Zoonotic Diseases 20 9 692 702 |
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Open Polar |
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National Inst. for Public Health and the Environment, Netherlands (RIVM): Webbased Archive of RIVM Publications (WARP) |
op_collection_id |
ftrivm |
language |
English |
topic |
GLM Picornaviridae bank vole cartogram reservoir host rodent vector |
spellingShingle |
GLM Picornaviridae bank vole cartogram reservoir host rodent vector Fevola, Cristina Rossi, Chiara Rosso, Fausta Girardi, Matteo Rosà, Roberto Manica, Mattia Delucchi, Luca Rocchini, Duccio Garzon-Lopez, Carol X Arnoldi, Daniele Bianchi, Alessandro Buzan, Elena Charbonnel, Nathalie Collini, Margherita Ďureje, Ľudovít Ecke, Frauke Ferrari, Nicola Fischer, Stefan Gillingham, Emma L Hörnfeldt, Birger Kazimírová, Mária Konečný, Adam Maas, Miriam Magnusson, Magnus Miller, Andrea Niemimaa, Jukka Nordström, Åke Obiegala, Anna Olsson, Gert Pedrini, Paolo Piálek, Jaroslav Reusken, Chantal B Rizzolli, Franco Romeo, Claudia Silaghi, Cornelia Sironen, Tarja Stanko, Michal Tagliapietra, Valentina Ulrich, Rainer G Vapalahti, Olli Voutilainen, Liina Wauters, Lucas Rizzoli, Annapaola Vaheri, Antti Jääskeläinen, Anne J Henttonen, Heikki Hauffe, Heidi C Geographical Distribution of Ljungan Virus in Small Mammals in Europe. |
topic_facet |
GLM Picornaviridae bank vole cartogram reservoir host rodent vector |
description |
Ljungan virus (LV), which belongs to the Parechovirus genus in the Picornaviridae family, was first isolated from bank voles (Myodes glareolus) in Sweden in 1998 and proposed as a zoonotic agent. To improve knowledge of the host association and geographical distribution of LV, tissues from 1685 animals belonging to multiple rodent and insectivore species from 12 European countries were screened for LV-RNA using reverse transcriptase (RT)-PCR. In addition, we investigated how the prevalence of LV-RNA in bank voles is associated with various intrinsic and extrinsic factors. We show that LV is widespread geographically, having been detected in at least one host species in nine European countries. Twelve out of 21 species screened were LV-RNA PCR positive, including, for the first time, the red vole (Myodes rutilus) and the root or tundra vole (Alexandromys formerly Microtus oeconomus), as well as in insectivores, including the bicolored white-toothed shrew (Crocidura leucodon) and the Valais shrew (Sorex antinorii). Results indicated that bank voles are the main rodent host for this virus (overall RT-PCR prevalence: 15.2%). Linear modeling of intrinsic and extrinsic factors that could impact LV prevalence showed a concave-down relationship between body mass and LV occurrence, so that subadults had the highest LV positivity, but LV in older animals was less prevalent. Also, LV prevalence was higher in autumn and lower in spring, and the amount of precipitation recorded during the 6 months preceding the trapping date was negatively correlated with the presence of the virus. Phylogenetic analysis on the 185 base pair species-specific sequence of the 5' untranslated region identified high genetic diversity (46.5%) between 80 haplotypes, although no geographical or host-specific patterns of diversity were detected. |
format |
Article in Journal/Newspaper |
author |
Fevola, Cristina Rossi, Chiara Rosso, Fausta Girardi, Matteo Rosà, Roberto Manica, Mattia Delucchi, Luca Rocchini, Duccio Garzon-Lopez, Carol X Arnoldi, Daniele Bianchi, Alessandro Buzan, Elena Charbonnel, Nathalie Collini, Margherita Ďureje, Ľudovít Ecke, Frauke Ferrari, Nicola Fischer, Stefan Gillingham, Emma L Hörnfeldt, Birger Kazimírová, Mária Konečný, Adam Maas, Miriam Magnusson, Magnus Miller, Andrea Niemimaa, Jukka Nordström, Åke Obiegala, Anna Olsson, Gert Pedrini, Paolo Piálek, Jaroslav Reusken, Chantal B Rizzolli, Franco Romeo, Claudia Silaghi, Cornelia Sironen, Tarja Stanko, Michal Tagliapietra, Valentina Ulrich, Rainer G Vapalahti, Olli Voutilainen, Liina Wauters, Lucas Rizzoli, Annapaola Vaheri, Antti Jääskeläinen, Anne J Henttonen, Heikki Hauffe, Heidi C |
author_facet |
Fevola, Cristina Rossi, Chiara Rosso, Fausta Girardi, Matteo Rosà, Roberto Manica, Mattia Delucchi, Luca Rocchini, Duccio Garzon-Lopez, Carol X Arnoldi, Daniele Bianchi, Alessandro Buzan, Elena Charbonnel, Nathalie Collini, Margherita Ďureje, Ľudovít Ecke, Frauke Ferrari, Nicola Fischer, Stefan Gillingham, Emma L Hörnfeldt, Birger Kazimírová, Mária Konečný, Adam Maas, Miriam Magnusson, Magnus Miller, Andrea Niemimaa, Jukka Nordström, Åke Obiegala, Anna Olsson, Gert Pedrini, Paolo Piálek, Jaroslav Reusken, Chantal B Rizzolli, Franco Romeo, Claudia Silaghi, Cornelia Sironen, Tarja Stanko, Michal Tagliapietra, Valentina Ulrich, Rainer G Vapalahti, Olli Voutilainen, Liina Wauters, Lucas Rizzoli, Annapaola Vaheri, Antti Jääskeläinen, Anne J Henttonen, Heikki Hauffe, Heidi C |
author_sort |
Fevola, Cristina |
title |
Geographical Distribution of Ljungan Virus in Small Mammals in Europe. |
title_short |
Geographical Distribution of Ljungan Virus in Small Mammals in Europe. |
title_full |
Geographical Distribution of Ljungan Virus in Small Mammals in Europe. |
title_fullStr |
Geographical Distribution of Ljungan Virus in Small Mammals in Europe. |
title_full_unstemmed |
Geographical Distribution of Ljungan Virus in Small Mammals in Europe. |
title_sort |
geographical distribution of ljungan virus in small mammals in europe. |
publishDate |
2020 |
url |
http://hdl.handle.net/10029/623873 https://doi.org/10.1089/vbz.2019.2542 |
genre |
Tundra |
genre_facet |
Tundra |
op_source |
Vector borne and zoonotic diseases (Larchmont, N.Y.) |
op_relation |
1557-7759 32487013 doi:10.1089/vbz.2019.2542 http://hdl.handle.net/10029/623873 Vector Borne Zoonotic Dis 2020; 20(9):692-702 |
op_doi |
https://doi.org/10.1089/vbz.2019.2542 |
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Vector-Borne and Zoonotic Diseases |
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20 |
container_issue |
9 |
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