Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies.
Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measur...
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Online Access: | http://hdl.handle.net/10029/622862 https://doi.org/10.1002/ijc.32073 |
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ftrivm:oai:rivm.openrepository.com:10029/622862 2023-05-15T18:34:49+02:00 Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. Gào, Xīn Wilsgaard, Tom Jansen, Eugène Hjm Holleczek, Bernd Zhang, Yan Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben 2018-12-18 http://hdl.handle.net/10029/622862 https://doi.org/10.1002/ijc.32073 en eng 1097-0215 30561010 doi:10.1002/ijc.32073 http://hdl.handle.net/10029/622862 Int J Cancer 2019; 145(1):49-57 info:eu-repo/semantics/closedAccess International journal of cancer breast cancer cohort study colorectal cancer d-ROM lung cancer oxidative stress prostate cancer Article 2018 ftrivm https://doi.org/10.1002/ijc.32073 2020-09-03T18:23:42Z Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM levels in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; subcohort: n = 1,000). Moreover, d-ROM was repeatedly measured at follow-ups of both studies. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were derived by (weighted) multivariable-adjusted Cox regression with time-dependent modeling of d-ROM levels for incident lung, colorectal, breast and prostate cancer. Individual study results were pooled by random effects meta-analysis. The HRs (95% CI) for comparison of top and bottom d-ROM tertile were statistically significant for lung (1.90 [1.25-2.89]), colorectal (1.70 [1.15-2.51]) and breast cancer incidence (1.45 [1.01-2.09]) but not for prostate cancer incidence (1.20 [0.84-1.72]). In conclusion, this individual participant data meta-analysis of two large population-based cohort studies with repeated d-ROM measurements yielded evidence for an involvement of high oxidative stress in carcinogenesis. Given the observed associations of pre-diagnostic d-ROM measurements with lung, colorectal and breast cancer incidence, subjects with increased serum d-ROM levels should be recommended to reduce these levels by lifestyle changes including smoking cessation, a healthy diet and an increase in physical activity. Article in Journal/Newspaper Tromsø National Inst. for Public Health and the Environment, Netherlands (RIVM): Webbased Archive of RIVM Publications (WARP) Esther ENVELOPE(-57.700,-57.700,-61.917,-61.917) Tromsø International Journal of Cancer 145 1 49 57 |
institution |
Open Polar |
collection |
National Inst. for Public Health and the Environment, Netherlands (RIVM): Webbased Archive of RIVM Publications (WARP) |
op_collection_id |
ftrivm |
language |
English |
topic |
breast cancer cohort study colorectal cancer d-ROM lung cancer oxidative stress prostate cancer |
spellingShingle |
breast cancer cohort study colorectal cancer d-ROM lung cancer oxidative stress prostate cancer Gào, Xīn Wilsgaard, Tom Jansen, Eugène Hjm Holleczek, Bernd Zhang, Yan Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. |
topic_facet |
breast cancer cohort study colorectal cancer d-ROM lung cancer oxidative stress prostate cancer |
description |
Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM levels in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; subcohort: n = 1,000). Moreover, d-ROM was repeatedly measured at follow-ups of both studies. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were derived by (weighted) multivariable-adjusted Cox regression with time-dependent modeling of d-ROM levels for incident lung, colorectal, breast and prostate cancer. Individual study results were pooled by random effects meta-analysis. The HRs (95% CI) for comparison of top and bottom d-ROM tertile were statistically significant for lung (1.90 [1.25-2.89]), colorectal (1.70 [1.15-2.51]) and breast cancer incidence (1.45 [1.01-2.09]) but not for prostate cancer incidence (1.20 [0.84-1.72]). In conclusion, this individual participant data meta-analysis of two large population-based cohort studies with repeated d-ROM measurements yielded evidence for an involvement of high oxidative stress in carcinogenesis. Given the observed associations of pre-diagnostic d-ROM measurements with lung, colorectal and breast cancer incidence, subjects with increased serum d-ROM levels should be recommended to reduce these levels by lifestyle changes including smoking cessation, a healthy diet and an increase in physical activity. |
format |
Article in Journal/Newspaper |
author |
Gào, Xīn Wilsgaard, Tom Jansen, Eugène Hjm Holleczek, Bernd Zhang, Yan Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben |
author_facet |
Gào, Xīn Wilsgaard, Tom Jansen, Eugène Hjm Holleczek, Bernd Zhang, Yan Xuan, Yang Anusruti, Ankita Brenner, Hermann Schöttker, Ben |
author_sort |
Gào, Xīn |
title |
Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. |
title_short |
Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. |
title_full |
Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. |
title_fullStr |
Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. |
title_full_unstemmed |
Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. |
title_sort |
pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: an individual participant data meta-analysis of two large population-based studies. |
publishDate |
2018 |
url |
http://hdl.handle.net/10029/622862 https://doi.org/10.1002/ijc.32073 |
long_lat |
ENVELOPE(-57.700,-57.700,-61.917,-61.917) |
geographic |
Esther Tromsø |
geographic_facet |
Esther Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
International journal of cancer |
op_relation |
1097-0215 30561010 doi:10.1002/ijc.32073 http://hdl.handle.net/10029/622862 Int J Cancer 2019; 145(1):49-57 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1002/ijc.32073 |
container_title |
International Journal of Cancer |
container_volume |
145 |
container_issue |
1 |
container_start_page |
49 |
op_container_end_page |
57 |
_version_ |
1766219742367973376 |