Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study
International audience BACKGROUND: Northeastern British Columbia (Canada) is an area of intense hydraulic fracturing for unconventional natural gas exploitation. There have been multiple reports of air and water contamination by volatile organic compounds in the vicinity of gas wells. Although these...
Published in: | Environment International |
---|---|
Main Authors: | , , , , , |
Other Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2018
|
Subjects: | |
Online Access: | https://riip.hal.science/pasteur-01688957 https://doi.org/10.1016/j.envint.2017.10.022 |
id |
ftriip:oai:HAL:pasteur-01688957v1 |
---|---|
record_format |
openpolar |
spelling |
ftriip:oai:HAL:pasteur-01688957v1 2024-09-15T18:29:11+00:00 Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study Caron-Beaudoin, Élyse Valter, Naomi Chevrier, Jonathan Ayotte, Pierre Frohlich, Katherine Verner, Marc-André Armand-Frappier Santé Biotechnologie Research Centre (INRS-AFSB) Institut National de la Recherche Scientifique Québec (INRS)-Réseau International des Instituts Pasteur (RIIP) Université de Montréal (UdeM) Université du Québec à Montréal = University of Québec in Montréal (UQAM) McGill University = Université McGill Montréal, Canada Hôpital du Saint-Sacrement CHU Québec (HSS) CHU de Québec–Université Laval Université Laval Québec (ULaval)-Université Laval Québec (ULaval) Institut National de Santé Publique du Québec Canada (INSPQ) This research project was funded through a new initiative grant program from the Université de Montréal Public Health Research Institute (IRSPUM), and the West Moberly First Nations. 2018-01 https://riip.hal.science/pasteur-01688957 https://doi.org/10.1016/j.envint.2017.10.022 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envint.2017.10.022 info:eu-repo/semantics/altIdentifier/pmid/29122312 pasteur-01688957 https://riip.hal.science/pasteur-01688957 doi:10.1016/j.envint.2017.10.022 PUBMED: 29122312 ISSN: 0160-4120 Environment International https://riip.hal.science/pasteur-01688957 Environment International, 2018, 110, pp.131 - 138. ⟨10.1016/j.envint.2017.10.022⟩ [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2018 ftriip https://doi.org/10.1016/j.envint.2017.10.022 2024-07-22T23:43:42Z International audience BACKGROUND: Northeastern British Columbia (Canada) is an area of intense hydraulic fracturing for unconventional natural gas exploitation. There have been multiple reports of air and water contamination by volatile organic compounds in the vicinity of gas wells. Although these chemicals are known developmental toxicants, no biomonitoring effort has been carried out in the region.OBJECTIVE: To evaluate gestational exposure to benzene and toluene in the Peace River Valley, Northeastern British Columbia (Canada).METHODS: Urine samples were collected over five consecutive days from 29 pregnant women. Metabolites of benzene (s-phenylmercapturic acid (S-PMA) and trans, trans-muconic acid (t,t-MA)) and toluene (s-benzylmercapturic acid (S-BMA)) were measured in pooled urine samples from each participant. Levels of benzene metabolites were compared to those from the general Canadian population and from a biomonitoring study of residents from an area of active gas exploitation in Pavillion, Wyoming (USA). Levels measured in participants from the two recruitment sites, and self-identifying as Indigenous or non-Indigenous, were also compared.RESULTS: Whereas the median S-PMA level (0.18μg/g creatinine) in our study was similar to that in the general Canadian population, the median t,t-MA level (180μg/g creatinine) was approximately 3.5 times higher. Five women had t,t-MA levels above the biological exposure index® proposed by the American Conference of Governmental Industrial Hygienists. The median urinary S-BMA level in our pilot study was 7.00μg/g creatinine. Urinary metabolite levels were slightly higher in self-identifying Indigenous women, but this difference was only statistically significant for S-PMA.DISCUSSION: Urinary t,t-MA levels, but not S-PMA levels, measured in our study are suggestive of a higher benzene exposure in participating pregnant women from the Peace River Valley than in the general Canadian population. Given the small sample size and limitations of t,t-MA measurements ... Article in Journal/Newspaper Peace River Réseau International des Instituts Pasteur, Paris: HAL-RIIP Environment International 110 131 138 |
institution |
Open Polar |
collection |
Réseau International des Instituts Pasteur, Paris: HAL-RIIP |
op_collection_id |
ftriip |
language |
English |
topic |
[SDV]Life Sciences [q-bio] |
spellingShingle |
[SDV]Life Sciences [q-bio] Caron-Beaudoin, Élyse Valter, Naomi Chevrier, Jonathan Ayotte, Pierre Frohlich, Katherine Verner, Marc-André Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study |
topic_facet |
[SDV]Life Sciences [q-bio] |
description |
International audience BACKGROUND: Northeastern British Columbia (Canada) is an area of intense hydraulic fracturing for unconventional natural gas exploitation. There have been multiple reports of air and water contamination by volatile organic compounds in the vicinity of gas wells. Although these chemicals are known developmental toxicants, no biomonitoring effort has been carried out in the region.OBJECTIVE: To evaluate gestational exposure to benzene and toluene in the Peace River Valley, Northeastern British Columbia (Canada).METHODS: Urine samples were collected over five consecutive days from 29 pregnant women. Metabolites of benzene (s-phenylmercapturic acid (S-PMA) and trans, trans-muconic acid (t,t-MA)) and toluene (s-benzylmercapturic acid (S-BMA)) were measured in pooled urine samples from each participant. Levels of benzene metabolites were compared to those from the general Canadian population and from a biomonitoring study of residents from an area of active gas exploitation in Pavillion, Wyoming (USA). Levels measured in participants from the two recruitment sites, and self-identifying as Indigenous or non-Indigenous, were also compared.RESULTS: Whereas the median S-PMA level (0.18μg/g creatinine) in our study was similar to that in the general Canadian population, the median t,t-MA level (180μg/g creatinine) was approximately 3.5 times higher. Five women had t,t-MA levels above the biological exposure index® proposed by the American Conference of Governmental Industrial Hygienists. The median urinary S-BMA level in our pilot study was 7.00μg/g creatinine. Urinary metabolite levels were slightly higher in self-identifying Indigenous women, but this difference was only statistically significant for S-PMA.DISCUSSION: Urinary t,t-MA levels, but not S-PMA levels, measured in our study are suggestive of a higher benzene exposure in participating pregnant women from the Peace River Valley than in the general Canadian population. Given the small sample size and limitations of t,t-MA measurements ... |
author2 |
Armand-Frappier Santé Biotechnologie Research Centre (INRS-AFSB) Institut National de la Recherche Scientifique Québec (INRS)-Réseau International des Instituts Pasteur (RIIP) Université de Montréal (UdeM) Université du Québec à Montréal = University of Québec in Montréal (UQAM) McGill University = Université McGill Montréal, Canada Hôpital du Saint-Sacrement CHU Québec (HSS) CHU de Québec–Université Laval Université Laval Québec (ULaval)-Université Laval Québec (ULaval) Institut National de Santé Publique du Québec Canada (INSPQ) This research project was funded through a new initiative grant program from the Université de Montréal Public Health Research Institute (IRSPUM), and the West Moberly First Nations. |
format |
Article in Journal/Newspaper |
author |
Caron-Beaudoin, Élyse Valter, Naomi Chevrier, Jonathan Ayotte, Pierre Frohlich, Katherine Verner, Marc-André |
author_facet |
Caron-Beaudoin, Élyse Valter, Naomi Chevrier, Jonathan Ayotte, Pierre Frohlich, Katherine Verner, Marc-André |
author_sort |
Caron-Beaudoin, Élyse |
title |
Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study |
title_short |
Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study |
title_full |
Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study |
title_fullStr |
Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study |
title_full_unstemmed |
Gestational exposure to volatile organic compounds (VOCs) in Northeastern British Columbia, Canada: A pilot study |
title_sort |
gestational exposure to volatile organic compounds (vocs) in northeastern british columbia, canada: a pilot study |
publisher |
HAL CCSD |
publishDate |
2018 |
url |
https://riip.hal.science/pasteur-01688957 https://doi.org/10.1016/j.envint.2017.10.022 |
genre |
Peace River |
genre_facet |
Peace River |
op_source |
ISSN: 0160-4120 Environment International https://riip.hal.science/pasteur-01688957 Environment International, 2018, 110, pp.131 - 138. ⟨10.1016/j.envint.2017.10.022⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envint.2017.10.022 info:eu-repo/semantics/altIdentifier/pmid/29122312 pasteur-01688957 https://riip.hal.science/pasteur-01688957 doi:10.1016/j.envint.2017.10.022 PUBMED: 29122312 |
op_doi |
https://doi.org/10.1016/j.envint.2017.10.022 |
container_title |
Environment International |
container_volume |
110 |
container_start_page |
131 |
op_container_end_page |
138 |
_version_ |
1810470591502745600 |