Transcriptomics and in vivo tests reveal novel mechanisms underlying endocrine disruption in an ecological sentinel, Nucella lapillus

• Published in: Molecular Ecology
• Main Authors: Pascoal, Sónia, Carvalho, Gary, Vasieva, Olga, Hughes, Roger, Cossins, Andrew, Fang, Yongxiang, Ashelford, Kevin, Olohan, Lisa, Barroso, Carlos, Mendo, Sónia, Creer, Simon
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2013
• Subjects: Nucella lapillus; PPAR signalling pathways; Roche 454 transcriptome sequencing; Endocrine disruption; Gene-environment interactions; High-density oligoarray; Imposex mechanism; Sonia; Dogwhelk
• Online Access: http://hdl.handle.net/10773/24611; https://doi.org/10.1111/mec.12137

Anthropogenic endocrine disruptors now contaminate all environments globally, with concomitant deleterious effects across diverse taxa. While most studies on endocrine disruption (ED) have focused on vertebrates, the superimposition of male sexual characteristics in the female dogwhelk, Nucella lapi...