Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean
publisher version Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate com...
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ftrhodesunivcory:vital:28931 2024-09-15T17:44:19+00:00 Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean Olsen, Elisabeth De Cerf, Christopher Dziwornu, Godwin A Puccinelli, Eleonora Parker-Nance, Shirley Ansorge, Isabelle J Samaai, Toufiek Dingle, Laura M K Edkins, Adrienne L Sunassee, Suthananda N 2016 5 pages pdf http://hdl.handle.net/10962/66300 https://corycommons.ru.ac.za/vital/access/manager/Repository/vital:28931 https://doi.org/10.17159/sajs.2016/20160202 English eng South African Journal of Science South African Journal of Science http://hdl.handle.net/10962/66300 vital:28931 https://corycommons.ru.ac.za/vital/access/manager/Repository/vital:28931 https://doi.org/10.17159/sajs.2016/20160202 Copyright held by the authors Use of this resource is governed by the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/ text article 2016 ftrhodesunivcory https://doi.org/10.17159/sajs.2016/20160202 2024-08-07T23:31:59Z publisher version Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean. Significance: This study will contribute to understanding the biodiversity and geographic distributions of sponges in the Southern Ocean. This multidisciplinary project has enabled the investigation of marine sponges for the presence of cytotoxic compounds. Further investigation will lead to the isolation and identification of cytotoxic compounds present in the active sponge extracts. University of Cape Town; South African Medical Research Council; National Research Foundation (South ... Article in Journal/Newspaper Antarc* Antarctic Marion Island Prince Edward Islands Southern Ocean Rhodes University Cory: Repository South African Journal of Science 112 11/12 5 |
institution |
Open Polar |
collection |
Rhodes University Cory: Repository |
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ftrhodesunivcory |
language |
English |
description |
publisher version Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean. Significance: This study will contribute to understanding the biodiversity and geographic distributions of sponges in the Southern Ocean. This multidisciplinary project has enabled the investigation of marine sponges for the presence of cytotoxic compounds. Further investigation will lead to the isolation and identification of cytotoxic compounds present in the active sponge extracts. University of Cape Town; South African Medical Research Council; National Research Foundation (South ... |
format |
Article in Journal/Newspaper |
author |
Olsen, Elisabeth De Cerf, Christopher Dziwornu, Godwin A Puccinelli, Eleonora Parker-Nance, Shirley Ansorge, Isabelle J Samaai, Toufiek Dingle, Laura M K Edkins, Adrienne L Sunassee, Suthananda N |
spellingShingle |
Olsen, Elisabeth De Cerf, Christopher Dziwornu, Godwin A Puccinelli, Eleonora Parker-Nance, Shirley Ansorge, Isabelle J Samaai, Toufiek Dingle, Laura M K Edkins, Adrienne L Sunassee, Suthananda N Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
author_facet |
Olsen, Elisabeth De Cerf, Christopher Dziwornu, Godwin A Puccinelli, Eleonora Parker-Nance, Shirley Ansorge, Isabelle J Samaai, Toufiek Dingle, Laura M K Edkins, Adrienne L Sunassee, Suthananda N |
author_sort |
Olsen, Elisabeth |
title |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_short |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_full |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_fullStr |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_full_unstemmed |
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean |
title_sort |
cytotoxic activity of marine sponge extracts from the sub-antarctic islands and the southern ocean |
publisher |
South African Journal of Science |
publishDate |
2016 |
url |
http://hdl.handle.net/10962/66300 https://corycommons.ru.ac.za/vital/access/manager/Repository/vital:28931 https://doi.org/10.17159/sajs.2016/20160202 |
genre |
Antarc* Antarctic Marion Island Prince Edward Islands Southern Ocean |
genre_facet |
Antarc* Antarctic Marion Island Prince Edward Islands Southern Ocean |
op_relation |
South African Journal of Science http://hdl.handle.net/10962/66300 vital:28931 https://corycommons.ru.ac.za/vital/access/manager/Repository/vital:28931 https://doi.org/10.17159/sajs.2016/20160202 |
op_rights |
Copyright held by the authors Use of this resource is governed by the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.17159/sajs.2016/20160202 |
container_title |
South African Journal of Science |
container_volume |
112 |
container_issue |
11/12 |
container_start_page |
5 |
_version_ |
1810491773804347392 |