Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa)
"Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min. Neotropical river otters (Lontra longicau...
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Language: | English |
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Frontiers Media, S. A.
2015
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Online Access: | http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1039 |
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ftrepnacmexico:oai:cibnor.repositorioinstitucional.mx:1001/1039 2023-05-15T16:05:23+02:00 Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) MYRNA BARJAU PEREZ MILICUA TANIA ZENTENO SAVIN Daniel Crocker JUAN PABLO GALLO REYNOSO 2015 application/pdf http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1039 eng eng Frontiers Media, S. A. info:eu-repo/semantics/reference/DOI/DOI:10.3389/fphys.2015.00212 info:eu-repo/semantics/reference/ISSN/ISSN: 1664-042X info:eu-repo/semantics/reference/URL/URL: https://www.frontiersin.org/journals/physiology citation:Barjau Pérez-Milicua, M., Zenteno-Savín, T., Crocker, D. E., & Gallo-Reynoso, J. P. (2015). Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa). Frontiers in Physiology, 6, 212. http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1039 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 CC-BY-NC-ND Frontiers in Physiology info:eu-repo/classification/AUTOR/hypoxia hypoxanthine-guanine phosphorybosiltransferase inosine 5′-monophosphate dehydrogenase purine salvage purine synthesis info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2401 info:eu-repo/classification/cti/240113 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2015 ftrepnacmexico https://doi.org/10.3389/fphys.2015.00212 2021-07-02T06:29:29Z "Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min. Neotropical river otters (Lontra longicaudis annectens) can hold their breath for about 30 s. Such periods of apnea may result in reduced oxygen concentration (hypoxia) and reduced blood supply (ischemia) to tissues. Production of adenosine 5′-triphosphate (ATP) requires oxygen, and most mammalian species, like the domestic pig (Sus scrofa), are not adapted to tolerate hypoxia and ischemia, conditions that result in ATP degradation. The objective of this study was to explore the differences in purine synthesis and recycling in erythrocytes and plasma of three mammalian species adapted to different environments: aquatic (northern elephant seal) (n = 11), semiaquatic (neotropical river otter) (n = 4), and terrestrial (domestic pig) (n = 11). Enzymatic activity of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) was determined by spectrophotometry, and activity of inosine 5′-monophosphate dehydrogenase (IMPDH) and the concentration of hypoxanthine (HX), inosine 5′-monophosphate (IMP), adenosine 5′-monophosphate (AMP), adenosine 5′-diphosphate (ADP), ATP, guanosine 5′-diphosphate (GDP), guanosine 5′-triphosphate (GTP), and xanthosine 5′-monophosphate (XMP) were determined by high-performance liquid chromatography (HPLC). The activities of HGPRT and IMPDH and the concentration of HX, IMP, AMP, ADP, ATP, GTP, and XMP in erythrocytes of domestic pigs were higher than in erythrocytes of northern elephant seals and river otters. These results suggest that under basal conditions (no diving, sleep apnea or exercise), aquatic, and semiaquatic mammals have less purine mobilization than their terrestrial counterparts." Article in Journal/Newspaper Elephant Seal Elephant Seals Lontra Repositorio Nacional Gobierno de Mexico Frontiers in Physiology 6 |
institution |
Open Polar |
collection |
Repositorio Nacional Gobierno de Mexico |
op_collection_id |
ftrepnacmexico |
language |
English |
topic |
info:eu-repo/classification/AUTOR/hypoxia hypoxanthine-guanine phosphorybosiltransferase inosine 5′-monophosphate dehydrogenase purine salvage purine synthesis info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2401 info:eu-repo/classification/cti/240113 |
spellingShingle |
info:eu-repo/classification/AUTOR/hypoxia hypoxanthine-guanine phosphorybosiltransferase inosine 5′-monophosphate dehydrogenase purine salvage purine synthesis info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2401 info:eu-repo/classification/cti/240113 MYRNA BARJAU PEREZ MILICUA TANIA ZENTENO SAVIN Daniel Crocker JUAN PABLO GALLO REYNOSO Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) |
topic_facet |
info:eu-repo/classification/AUTOR/hypoxia hypoxanthine-guanine phosphorybosiltransferase inosine 5′-monophosphate dehydrogenase purine salvage purine synthesis info:eu-repo/classification/cti/2 info:eu-repo/classification/cti/24 info:eu-repo/classification/cti/2401 info:eu-repo/classification/cti/240113 |
description |
"Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min. Neotropical river otters (Lontra longicaudis annectens) can hold their breath for about 30 s. Such periods of apnea may result in reduced oxygen concentration (hypoxia) and reduced blood supply (ischemia) to tissues. Production of adenosine 5′-triphosphate (ATP) requires oxygen, and most mammalian species, like the domestic pig (Sus scrofa), are not adapted to tolerate hypoxia and ischemia, conditions that result in ATP degradation. The objective of this study was to explore the differences in purine synthesis and recycling in erythrocytes and plasma of three mammalian species adapted to different environments: aquatic (northern elephant seal) (n = 11), semiaquatic (neotropical river otter) (n = 4), and terrestrial (domestic pig) (n = 11). Enzymatic activity of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) was determined by spectrophotometry, and activity of inosine 5′-monophosphate dehydrogenase (IMPDH) and the concentration of hypoxanthine (HX), inosine 5′-monophosphate (IMP), adenosine 5′-monophosphate (AMP), adenosine 5′-diphosphate (ADP), ATP, guanosine 5′-diphosphate (GDP), guanosine 5′-triphosphate (GTP), and xanthosine 5′-monophosphate (XMP) were determined by high-performance liquid chromatography (HPLC). The activities of HGPRT and IMPDH and the concentration of HX, IMP, AMP, ADP, ATP, GTP, and XMP in erythrocytes of domestic pigs were higher than in erythrocytes of northern elephant seals and river otters. These results suggest that under basal conditions (no diving, sleep apnea or exercise), aquatic, and semiaquatic mammals have less purine mobilization than their terrestrial counterparts." |
format |
Article in Journal/Newspaper |
author |
MYRNA BARJAU PEREZ MILICUA TANIA ZENTENO SAVIN Daniel Crocker JUAN PABLO GALLO REYNOSO |
author_facet |
MYRNA BARJAU PEREZ MILICUA TANIA ZENTENO SAVIN Daniel Crocker JUAN PABLO GALLO REYNOSO |
author_sort |
MYRNA BARJAU PEREZ MILICUA |
title |
Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) |
title_short |
Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) |
title_full |
Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) |
title_fullStr |
Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) |
title_full_unstemmed |
Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) |
title_sort |
hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (mirounga angustirostris), semi-aquatic (lontra longicaudis annectens) and terrestrial (sus scrofa) |
publisher |
Frontiers Media, S. A. |
publishDate |
2015 |
url |
http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1039 |
genre |
Elephant Seal Elephant Seals Lontra |
genre_facet |
Elephant Seal Elephant Seals Lontra |
op_source |
Frontiers in Physiology |
op_relation |
info:eu-repo/semantics/reference/DOI/DOI:10.3389/fphys.2015.00212 info:eu-repo/semantics/reference/ISSN/ISSN: 1664-042X info:eu-repo/semantics/reference/URL/URL: https://www.frontiersin.org/journals/physiology citation:Barjau Pérez-Milicua, M., Zenteno-Savín, T., Crocker, D. E., & Gallo-Reynoso, J. P. (2015). Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa). Frontiers in Physiology, 6, 212. http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/1039 |
op_rights |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.3389/fphys.2015.00212 |
container_title |
Frontiers in Physiology |
container_volume |
6 |
_version_ |
1766401286805127168 |