Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity
Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in...
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ftrepec:oai:RePEc:plo:pone00:0153611 2023-05-15T17:42:46+02:00 Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity Sofus C Larsen Lars Ängquist Max Moldovan Ville Huikari Sylvain Sebert Alana Cavadino Tarunveer Singh Ahluwalia Tea Skaaby Allan Linneberg Lise Lotte N Husemoen Ulla Toft Oluf Pedersen Torben Hansen Karl-Heinz Herzig Marjo-Riitta Jarvelin Chris Power Elina Hyppönen Berit L Heitmann Thorkild I A Sørensen https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153611 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153611&type=printable unknown https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153611 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153611&type=printable article ftrepec 2020-12-04T13:31:49Z Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity. Article in Journal/Newspaper Northern Finland RePEc (Research Papers in Economics) |
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Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity. |
format |
Article in Journal/Newspaper |
author |
Sofus C Larsen Lars Ängquist Max Moldovan Ville Huikari Sylvain Sebert Alana Cavadino Tarunveer Singh Ahluwalia Tea Skaaby Allan Linneberg Lise Lotte N Husemoen Ulla Toft Oluf Pedersen Torben Hansen Karl-Heinz Herzig Marjo-Riitta Jarvelin Chris Power Elina Hyppönen Berit L Heitmann Thorkild I A Sørensen |
spellingShingle |
Sofus C Larsen Lars Ängquist Max Moldovan Ville Huikari Sylvain Sebert Alana Cavadino Tarunveer Singh Ahluwalia Tea Skaaby Allan Linneberg Lise Lotte N Husemoen Ulla Toft Oluf Pedersen Torben Hansen Karl-Heinz Herzig Marjo-Riitta Jarvelin Chris Power Elina Hyppönen Berit L Heitmann Thorkild I A Sørensen Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity |
author_facet |
Sofus C Larsen Lars Ängquist Max Moldovan Ville Huikari Sylvain Sebert Alana Cavadino Tarunveer Singh Ahluwalia Tea Skaaby Allan Linneberg Lise Lotte N Husemoen Ulla Toft Oluf Pedersen Torben Hansen Karl-Heinz Herzig Marjo-Riitta Jarvelin Chris Power Elina Hyppönen Berit L Heitmann Thorkild I A Sørensen |
author_sort |
Sofus C Larsen |
title |
Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity |
title_short |
Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity |
title_full |
Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity |
title_fullStr |
Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity |
title_full_unstemmed |
Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity |
title_sort |
serum 25-hydroxyvitamin d status and longitudinal changes in weight and waist circumference: influence of genetic predisposition to adiposity |
url |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153611 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153611&type=printable |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153611 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0153611&type=printable |
_version_ |
1766144691389071360 |