The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia
Background: In the Arkhangelsk region of Northern Russia, multidrug-resistant (MDR) tuberculosis (TB) rates in new cases are amongst the highest in the world. In 2014, MDR-TB rates reached 31.7% among new cases and 56.9% among retreatment cases. The development of new diagnostic tools allows for fas...
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ftrepec:oai:RePEc:plo:pone00:0152761 2023-05-15T15:23:45+02:00 The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia Platon Eliseev Grigory Balantcev Elena Nikishova Anastasia Gaida Elena Bogdanova Donald Enarson Tara Ornstein Anne Detjen Russell Dacombe Elena Gospodarevskaya Patrick P J Phillips Gillian Mann Stephen Bertel Squire Andrei Mariandyshev https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152761 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152761&type=printable unknown https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152761 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152761&type=printable article ftrepec 2020-12-04T13:35:06Z Background: In the Arkhangelsk region of Northern Russia, multidrug-resistant (MDR) tuberculosis (TB) rates in new cases are amongst the highest in the world. In 2014, MDR-TB rates reached 31.7% among new cases and 56.9% among retreatment cases. The development of new diagnostic tools allows for faster detection of both TB and MDR-TB and should lead to reduced transmission by earlier initiation of anti-TB therapy. Study Aim: The PROVE-IT (Policy Relevant Outcomes from Validating Evidence on Impact) Russia study aimed to assess the impact of the implementation of line probe assay (LPA) as part of an LPA-based diagnostic algorithm for patients with presumptive MDR-TB focusing on time to treatment initiation with time from first-care seeking visit to the initiation of MDR-TB treatment rather than diagnostic accuracy as the primary outcome, and to assess treatment outcomes. We hypothesized that the implementation of LPA would result in faster time to treatment initiation and better treatment outcomes. Methods: A culture-based diagnostic algorithm used prior to LPA implementation was compared to an LPA-based algorithm that replaced BacTAlert and Löwenstein Jensen (LJ) for drug sensitivity testing. A total of 295 MDR-TB patients were included in the study, 163 diagnosed with the culture-based algorithm, 132 with the LPA-based algorithm. Results: Among smear positive patients, the implementation of the LPA-based algorithm was associated with a median decrease in time to MDR-TB treatment initiation of 50 and 66 days compared to the culture-based algorithm (BacTAlert and LJ respectively, p Article in Journal/Newspaper Arkhangelsk RePEc (Research Papers in Economics) |
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RePEc (Research Papers in Economics) |
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Background: In the Arkhangelsk region of Northern Russia, multidrug-resistant (MDR) tuberculosis (TB) rates in new cases are amongst the highest in the world. In 2014, MDR-TB rates reached 31.7% among new cases and 56.9% among retreatment cases. The development of new diagnostic tools allows for faster detection of both TB and MDR-TB and should lead to reduced transmission by earlier initiation of anti-TB therapy. Study Aim: The PROVE-IT (Policy Relevant Outcomes from Validating Evidence on Impact) Russia study aimed to assess the impact of the implementation of line probe assay (LPA) as part of an LPA-based diagnostic algorithm for patients with presumptive MDR-TB focusing on time to treatment initiation with time from first-care seeking visit to the initiation of MDR-TB treatment rather than diagnostic accuracy as the primary outcome, and to assess treatment outcomes. We hypothesized that the implementation of LPA would result in faster time to treatment initiation and better treatment outcomes. Methods: A culture-based diagnostic algorithm used prior to LPA implementation was compared to an LPA-based algorithm that replaced BacTAlert and Löwenstein Jensen (LJ) for drug sensitivity testing. A total of 295 MDR-TB patients were included in the study, 163 diagnosed with the culture-based algorithm, 132 with the LPA-based algorithm. Results: Among smear positive patients, the implementation of the LPA-based algorithm was associated with a median decrease in time to MDR-TB treatment initiation of 50 and 66 days compared to the culture-based algorithm (BacTAlert and LJ respectively, p |
format |
Article in Journal/Newspaper |
author |
Platon Eliseev Grigory Balantcev Elena Nikishova Anastasia Gaida Elena Bogdanova Donald Enarson Tara Ornstein Anne Detjen Russell Dacombe Elena Gospodarevskaya Patrick P J Phillips Gillian Mann Stephen Bertel Squire Andrei Mariandyshev |
spellingShingle |
Platon Eliseev Grigory Balantcev Elena Nikishova Anastasia Gaida Elena Bogdanova Donald Enarson Tara Ornstein Anne Detjen Russell Dacombe Elena Gospodarevskaya Patrick P J Phillips Gillian Mann Stephen Bertel Squire Andrei Mariandyshev The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia |
author_facet |
Platon Eliseev Grigory Balantcev Elena Nikishova Anastasia Gaida Elena Bogdanova Donald Enarson Tara Ornstein Anne Detjen Russell Dacombe Elena Gospodarevskaya Patrick P J Phillips Gillian Mann Stephen Bertel Squire Andrei Mariandyshev |
author_sort |
Platon Eliseev |
title |
The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia |
title_short |
The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia |
title_full |
The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia |
title_fullStr |
The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia |
title_full_unstemmed |
The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia |
title_sort |
impact of a line probe assay based diagnostic algorithm on time to treatment initiation and treatment outcomes for multidrug resistant tb patients in arkhangelsk region, russia |
url |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152761 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152761&type=printable |
genre |
Arkhangelsk |
genre_facet |
Arkhangelsk |
op_relation |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152761 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152761&type=printable |
_version_ |
1766354389719580672 |