Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study
Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the...
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ftrepec:oai:RePEc:plo:pone00:0140478 2023-05-15T17:44:36+02:00 Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140478 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140478&type=printable unknown https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140478 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140478&type=printable article ftrepec 2020-12-04T13:38:11Z Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH)D concentration in GWAS were also associated with plasma 25(OH)D in our study (p-trend Article in Journal/Newspaper Northern Sweden RePEc (Research Papers in Economics) |
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RePEc (Research Papers in Economics) |
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Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies have examined SNPs in vitamin D-related genes other than the vitamin D receptor (VDR) gene and particularly have not examined the association with the retinoid X receptor alpha (RXRA) gene which may be a key vitamin D pathway gene. We conducted a nested case-control study of 734 cases and 1435 individually matched controls from a population-based prospective cohort study, the Northern Sweden Mammary Screening Cohort. Tag and functional SNPs were genotyped for the VDR, cytochrome p450 24A1 (CYP24A1), and RXRA genes. We also genotyped specific SNPs in four other genes related to vitamin D metabolism and signaling (GC/VDBP, CYP2R1, DHCR7, and CYP27B1). SNPs in the CYP2R1, DHCR7, and VDBP gene regions that were associated with circulating 25(OH)D concentration in GWAS were also associated with plasma 25(OH)D in our study (p-trend |
format |
Article in Journal/Newspaper |
author |
Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte |
spellingShingle |
Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study |
author_facet |
Tess V Clendenen Wenzhen Ge Karen L Koenig Tomas Axelsson Mengling Liu Yelena Afanasyeva Anne Andersson Alan A Arslan Yu Chen Göran Hallmans Per Lenner Tomas Kirchhoff Eva Lundin Roy E Shore Malin Sund Anne Zeleniuch-Jacquotte |
author_sort |
Tess V Clendenen |
title |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study |
title_short |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study |
title_full |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study |
title_fullStr |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study |
title_full_unstemmed |
Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study |
title_sort |
genetic polymorphisms in vitamin d metabolism and signaling genes and risk of breast cancer: a nested case-control study |
url |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140478 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140478&type=printable |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140478 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140478&type=printable |
_version_ |
1766146853034786816 |