Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort
Background: Atopic dermatitis (AD) is known to predate asthma and other atopic disorders described under the term “atopic march”. However, this classic sequence is not always present and only a few studies have addressed children at risk of developing asthma. The objective of this study is to define...
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ftrepec:oai:RePEc:plo:pone00:0131369 2023-05-15T17:53:36+02:00 Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort Flore Amat Philippe Saint-Pierre Emmanuelle Bourrat Ariane Nemni Rémy Couderc Emmanuelle Boutmy-Deslandes Fatiha Sahraoui Isabelle Pansé Martine Bagot Sébastien Foueré Jocelyne Just https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131369 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131369&type=printable unknown https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131369 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131369&type=printable article ftrepec 2020-12-04T13:33:13Z Background: Atopic dermatitis (AD) is known to predate asthma and other atopic disorders described under the term “atopic march”. However, this classic sequence is not always present and only a few studies have addressed children at risk of developing asthma. The objective of this study is to define early-onset AD phenotypes leading to asthma. Methods: We performed a cluster analysis with 9 variables of 214 infants with early-onset AD prospectively enrolled in the ORCA cohort and followed each year on the occurrence of asthma until the age of 6. Results: We identified 3 clusters - cluster 1 (n = 94) with low to no sensitization to food (27.7%) or aeroallergens (10.6%) and moderate AD severity (SCORAD 25.29 +/- 14.6) called “AD with low sensitization”; - cluster 2 (n = 84) characterized by a higher AD severity (SCORAD 32.66+/-16.6) and frequent sensitization to food (98.9%) or aeroallergens (26.2%), most likely multiple (96.4% for food allergens), called “AD with multiple sensitizations” - cluster 3 (n = 36) with parental history, moderate AD severity (SCORAD 24.46+/-15.7), moderate rate of sensitization to food allergens (38.9%) (exclusively single) with no sensitization to aeroallergens, called “AD with familial history of asthma”. Percentages of children suffering from asthma at the age of 6 were higher in clusters 2 and 3 (36.1% and 33.3% respectively versus 14.9% in cluster 1, p Article in Journal/Newspaper Orca RePEc (Research Papers in Economics) |
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Background: Atopic dermatitis (AD) is known to predate asthma and other atopic disorders described under the term “atopic march”. However, this classic sequence is not always present and only a few studies have addressed children at risk of developing asthma. The objective of this study is to define early-onset AD phenotypes leading to asthma. Methods: We performed a cluster analysis with 9 variables of 214 infants with early-onset AD prospectively enrolled in the ORCA cohort and followed each year on the occurrence of asthma until the age of 6. Results: We identified 3 clusters - cluster 1 (n = 94) with low to no sensitization to food (27.7%) or aeroallergens (10.6%) and moderate AD severity (SCORAD 25.29 +/- 14.6) called “AD with low sensitization”; - cluster 2 (n = 84) characterized by a higher AD severity (SCORAD 32.66+/-16.6) and frequent sensitization to food (98.9%) or aeroallergens (26.2%), most likely multiple (96.4% for food allergens), called “AD with multiple sensitizations” - cluster 3 (n = 36) with parental history, moderate AD severity (SCORAD 24.46+/-15.7), moderate rate of sensitization to food allergens (38.9%) (exclusively single) with no sensitization to aeroallergens, called “AD with familial history of asthma”. Percentages of children suffering from asthma at the age of 6 were higher in clusters 2 and 3 (36.1% and 33.3% respectively versus 14.9% in cluster 1, p |
format |
Article in Journal/Newspaper |
author |
Flore Amat Philippe Saint-Pierre Emmanuelle Bourrat Ariane Nemni Rémy Couderc Emmanuelle Boutmy-Deslandes Fatiha Sahraoui Isabelle Pansé Martine Bagot Sébastien Foueré Jocelyne Just |
spellingShingle |
Flore Amat Philippe Saint-Pierre Emmanuelle Bourrat Ariane Nemni Rémy Couderc Emmanuelle Boutmy-Deslandes Fatiha Sahraoui Isabelle Pansé Martine Bagot Sébastien Foueré Jocelyne Just Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort |
author_facet |
Flore Amat Philippe Saint-Pierre Emmanuelle Bourrat Ariane Nemni Rémy Couderc Emmanuelle Boutmy-Deslandes Fatiha Sahraoui Isabelle Pansé Martine Bagot Sébastien Foueré Jocelyne Just |
author_sort |
Flore Amat |
title |
Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort |
title_short |
Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort |
title_full |
Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort |
title_fullStr |
Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort |
title_full_unstemmed |
Early-Onset Atopic Dermatitis in Children: Which Are the Phenotypes at Risk of Asthma? Results from the ORCA Cohort |
title_sort |
early-onset atopic dermatitis in children: which are the phenotypes at risk of asthma? results from the orca cohort |
url |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131369 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131369&type=printable |
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Orca |
genre_facet |
Orca |
op_relation |
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131369 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0131369&type=printable |
_version_ |
1766161296117465088 |