A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe

Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from easte...

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Main Authors: Andrey V Khrunin, Denis V Khokhrin, Irina N Filippova, Tõnu Esko, Mari Nelis, Natalia A Bebyakova, Natalia L Bolotova, Janis Klovins, Liene Nikitina-Zake, Karola Rehnström, Samuli Ripatti, Stefan Schreiber, Andre Franke, Milan Macek, Veronika Krulišová, Jan Lubinski, Andres Metspalu, Svetlana A Limborska
Format: Article in Journal/Newspaper
Language:unknown
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Online Access:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058552
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0058552&type=printable
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spelling ftrepec:oai:RePEc:plo:pone00:0058552 2024-04-14T08:04:51+00:00 A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe Andrey V Khrunin Denis V Khokhrin Irina N Filippova Tõnu Esko Mari Nelis Natalia A Bebyakova Natalia L Bolotova Janis Klovins Liene Nikitina-Zake Karola Rehnström Samuli Ripatti Stefan Schreiber Andre Franke Milan Macek Veronika Krulišová Jan Lubinski Andres Metspalu Svetlana A Limborska https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058552 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0058552&type=printable unknown https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058552 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0058552&type=printable article ftrepec 2024-03-19T10:29:16Z Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from eastern (northeastern) Europe: four Russian populations from European Russia, and three populations from the northernmost Finno-Ugric ethnicities (Veps and two contrast groups of Komi people). These were compared with several reference European samples, including Finns, Estonians, Latvians, Poles, Czechs, Germans, and Italians. The results obtained demonstrated genetic heterogeneity of populations living in the region studied. Russians from the central part of European Russia (Tver, Murom, and Kursk) exhibited similarities with populations from central–eastern Europe, and were distant from Russian sample from the northern Russia (Mezen district, Archangelsk region). Komi samples, especially Izhemski Komi, were significantly different from all other populations studied. These can be considered as a second pole of genetic diversity in northern Europe (in addition to the pole, occupied by Finns), as they had a distinct ancestry component. Russians from Mezen and the Finnic-speaking Veps were positioned between the two poles, but differed from each other in the proportions of Komi and Finnic ancestries. In general, our data provides a more complete genetic map of Europe accounting for the diversity in its most eastern (northeastern) populations. Article in Journal/Newspaper Archangelsk Mezen Mezen' RePEc (Research Papers in Economics)
institution Open Polar
collection RePEc (Research Papers in Economics)
op_collection_id ftrepec
language unknown
description Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from eastern (northeastern) Europe: four Russian populations from European Russia, and three populations from the northernmost Finno-Ugric ethnicities (Veps and two contrast groups of Komi people). These were compared with several reference European samples, including Finns, Estonians, Latvians, Poles, Czechs, Germans, and Italians. The results obtained demonstrated genetic heterogeneity of populations living in the region studied. Russians from the central part of European Russia (Tver, Murom, and Kursk) exhibited similarities with populations from central–eastern Europe, and were distant from Russian sample from the northern Russia (Mezen district, Archangelsk region). Komi samples, especially Izhemski Komi, were significantly different from all other populations studied. These can be considered as a second pole of genetic diversity in northern Europe (in addition to the pole, occupied by Finns), as they had a distinct ancestry component. Russians from Mezen and the Finnic-speaking Veps were positioned between the two poles, but differed from each other in the proportions of Komi and Finnic ancestries. In general, our data provides a more complete genetic map of Europe accounting for the diversity in its most eastern (northeastern) populations.
format Article in Journal/Newspaper
author Andrey V Khrunin
Denis V Khokhrin
Irina N Filippova
Tõnu Esko
Mari Nelis
Natalia A Bebyakova
Natalia L Bolotova
Janis Klovins
Liene Nikitina-Zake
Karola Rehnström
Samuli Ripatti
Stefan Schreiber
Andre Franke
Milan Macek
Veronika Krulišová
Jan Lubinski
Andres Metspalu
Svetlana A Limborska
spellingShingle Andrey V Khrunin
Denis V Khokhrin
Irina N Filippova
Tõnu Esko
Mari Nelis
Natalia A Bebyakova
Natalia L Bolotova
Janis Klovins
Liene Nikitina-Zake
Karola Rehnström
Samuli Ripatti
Stefan Schreiber
Andre Franke
Milan Macek
Veronika Krulišová
Jan Lubinski
Andres Metspalu
Svetlana A Limborska
A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
author_facet Andrey V Khrunin
Denis V Khokhrin
Irina N Filippova
Tõnu Esko
Mari Nelis
Natalia A Bebyakova
Natalia L Bolotova
Janis Klovins
Liene Nikitina-Zake
Karola Rehnström
Samuli Ripatti
Stefan Schreiber
Andre Franke
Milan Macek
Veronika Krulišová
Jan Lubinski
Andres Metspalu
Svetlana A Limborska
author_sort Andrey V Khrunin
title A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_short A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_full A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_fullStr A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_full_unstemmed A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe
title_sort genome-wide analysis of populations from european russia reveals a new pole of genetic diversity in northern europe
url https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058552
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0058552&type=printable
genre Archangelsk
Mezen
Mezen'
genre_facet Archangelsk
Mezen
Mezen'
op_relation https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058552
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0058552&type=printable
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