Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review

• Main Authors: Nadeem Sarwar, Thor Aspelund, Gudny Eiriksdottir, Reeta Gobin, Sreenivasa Rao Kondapally Seshasai, Nita G Forouhi, Gunnar Sigurdsson, John Danesh, Vilmundur Gudnason
• Format: Article in Journal/Newspaper
• Language: unknown
• Subjects: Iceland
• Online Access: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000278; https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000278&type=printable

Sarwar and colleagues report data from a prospective cohort in Iceland, and carry out a meta-analysis to evaluate the association between blood sugar levels and risk of coronary heart disease in people who do not have diabetes. Strong evidence for an increase in risk was not found.Background: Associations between circulating markers of dysglycaemia and coronary heart disease (CHD) risk in people without diabetes have not been reliably characterised. We report new data from a prospective study and a systematic review to help quantify these associations. Methods and Findings: Fasting and post-load glucose levels were measured in 18,569 participants in the population-based Reykjavik study, yielding 4,664 incident CHD outcomes during 23.5 y of mean follow-up. In people with no known history of diabetes at the baseline survey, the hazard ratio (HR) for CHD, adjusted for several conventional risk factors, was 2.37 (95% CI 1.79–3.14) in individuals with fasting glucose ≥7.0 mmol/l compared to those