Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review
Sarwar and colleagues report data from a prospective cohort in Iceland, and carry out a meta-analysis to evaluate the association between blood sugar levels and risk of coronary heart disease in people who do not have diabetes. Strong evidence for an increase in risk was not found.Background: Associ...
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ftrepec:oai:RePEc:plo:pmed00:1000278 2024-04-14T08:13:44+00:00 Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review Nadeem Sarwar Thor Aspelund Gudny Eiriksdottir Reeta Gobin Sreenivasa Rao Kondapally Seshasai Nita G Forouhi Gunnar Sigurdsson John Danesh Vilmundur Gudnason https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000278 https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000278&type=printable unknown https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000278 https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000278&type=printable article ftrepec 2024-03-19T10:36:25Z Sarwar and colleagues report data from a prospective cohort in Iceland, and carry out a meta-analysis to evaluate the association between blood sugar levels and risk of coronary heart disease in people who do not have diabetes. Strong evidence for an increase in risk was not found.Background: Associations between circulating markers of dysglycaemia and coronary heart disease (CHD) risk in people without diabetes have not been reliably characterised. We report new data from a prospective study and a systematic review to help quantify these associations. Methods and Findings: Fasting and post-load glucose levels were measured in 18,569 participants in the population-based Reykjavik study, yielding 4,664 incident CHD outcomes during 23.5 y of mean follow-up. In people with no known history of diabetes at the baseline survey, the hazard ratio (HR) for CHD, adjusted for several conventional risk factors, was 2.37 (95% CI 1.79–3.14) in individuals with fasting glucose ≥7.0 mmol/l compared to those Article in Journal/Newspaper Iceland RePEc (Research Papers in Economics) |
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Sarwar and colleagues report data from a prospective cohort in Iceland, and carry out a meta-analysis to evaluate the association between blood sugar levels and risk of coronary heart disease in people who do not have diabetes. Strong evidence for an increase in risk was not found.Background: Associations between circulating markers of dysglycaemia and coronary heart disease (CHD) risk in people without diabetes have not been reliably characterised. We report new data from a prospective study and a systematic review to help quantify these associations. Methods and Findings: Fasting and post-load glucose levels were measured in 18,569 participants in the population-based Reykjavik study, yielding 4,664 incident CHD outcomes during 23.5 y of mean follow-up. In people with no known history of diabetes at the baseline survey, the hazard ratio (HR) for CHD, adjusted for several conventional risk factors, was 2.37 (95% CI 1.79–3.14) in individuals with fasting glucose ≥7.0 mmol/l compared to those |
format |
Article in Journal/Newspaper |
author |
Nadeem Sarwar Thor Aspelund Gudny Eiriksdottir Reeta Gobin Sreenivasa Rao Kondapally Seshasai Nita G Forouhi Gunnar Sigurdsson John Danesh Vilmundur Gudnason |
spellingShingle |
Nadeem Sarwar Thor Aspelund Gudny Eiriksdottir Reeta Gobin Sreenivasa Rao Kondapally Seshasai Nita G Forouhi Gunnar Sigurdsson John Danesh Vilmundur Gudnason Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review |
author_facet |
Nadeem Sarwar Thor Aspelund Gudny Eiriksdottir Reeta Gobin Sreenivasa Rao Kondapally Seshasai Nita G Forouhi Gunnar Sigurdsson John Danesh Vilmundur Gudnason |
author_sort |
Nadeem Sarwar |
title |
Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review |
title_short |
Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review |
title_full |
Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review |
title_fullStr |
Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review |
title_full_unstemmed |
Markers of Dysglycaemia and Risk of Coronary Heart Disease in People without Diabetes: Reykjavik Prospective Study and Systematic Review |
title_sort |
markers of dysglycaemia and risk of coronary heart disease in people without diabetes: reykjavik prospective study and systematic review |
url |
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000278 https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000278&type=printable |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000278 https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1000278&type=printable |
_version_ |
1796311776457916416 |