A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study

• Published in: The Lancet Oncology
• Main Authors: Bancroft, E. K., Page, E. C., Brook, M. N., Thomas, S., Taylor, N., Pope, J., McHugh, J., Jones, A. B., Karlsson, Q., Merson, S., Ong, K. R., Hoffman, J., Huber, C., Maehle, L., Grindedal, E. M., Stormorken, A., Evans, D. G., Rothwell, J., Lalloo, F., Brady, A. F., Bartlett, M., Snape, K., Hanson, H., James, P., McKinley, J., Mascarenhas, L., Syngal, S., Ukaegbu, C., Side, L., Thomas, T., Barwell, J., Teixeira, M. R., Izatt, L., Suri, M., Macrae, F. A., Poplawski, N., Chen-Shtoyerman, R., Ahmed, M., Musgrave, H., Nicolai, N., Greenhalgh, L., Brewer, C., Pachter, N., Spigelman, A. D., Azzabi, A., Helfand, B. T., Halliday, D., Buys, S., Ramon, Y. Cajal T., Donaldson, A., Cooney, K. A., Harris, M., McGrath, J., Davidson, R., Taylor, A., Cooke, P., Myhill, K., Hogben, M., Aaronson, N. K., Ardern-Jones, A., Bangma, C. H., Castro, E., Dearnaley, D., Dias, A., Dudderidge, T., Eccles, D. M., Green, K., Eyfjord, J., Falconer, A., Foster, C. S., Gronberg, H., Hamdy, F. C., Johannsson, O., Khoo, V., Lilja, H., Lindeman, G. J., Lubinski, J., Axcrona, K., Mikropoulos, C., Mitra, A. V., Moynihan, C., Ni Raghallaigh, H., Rennert, G., Collier, R., Offman, J., Kote-Jarai, Z., Eeles, R. A.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2021
• Subjects: Adult; Aged; Biomarkers; Tumor/blood; DNA Mismatch Repair/*genetics; DNA-Binding Proteins/genetics; *Early Detection of Cancer; Germ-Line Mutation; Heterozygote; Humans; Incidence; Male; Middle Aged; MutS Homolog 2 Protein/genetics; Prospective Studies; Prostate-Specific Antigen/blood; Prostatic Neoplasms/*diagnosis/epidemiology/genetics; Española; Lynch; Marsden; Arctic
• Online Access: https://doi.org/10.1016/s1470-2045(21)00522-2; https://rde.dspace-express.com/handle/11287/622259

BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch re...