Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it
Since Taubenberger´s team recreated each of the genes of influenza virus that caused the terrible pandemic of 1918-19 using the technique called reverse genetics and checked the infectious capacity of the newborn virus, it seems that its high pathogenicity may be due to disregulation of the innate i...
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ftranjojs:oai:ojs.pkp.sfu.ca:article/935 2023-05-15T15:34:27+02:00 Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it El virus de la gripe aviar: nuevos aspectos relativos a su patogenicidad y a estrategias para combatirlo Cabezas Fernández del Campo, José Antonio 2009-06-21 application/pdf http://www.analesranf.com/index.php/aranf/article/view/935 spa spa Real Academia Nacional de Farmacia http://www.analesranf.com/index.php/aranf/article/view/935/941 Anales de la Real Academia Nacional de Farmacia; Vol. 75, Núm. 2 (2009) 1697-428X 1697-4271 Avian flu; Avian influenza virus; Pathogenicity; Cytokines; Statins; 1918-1919 influenza pandemic; “Spanish flu”; Vaccines against avian flu. Gripe aviar; Influenza aviar; Patogenicidad; Citocinas; Estatinas; Gripe 1918-19; Vacunas anti-gripe aviar. info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2009 ftranjojs 2018-09-27T18:42:12Z Since Taubenberger´s team recreated each of the genes of influenza virus that caused the terrible pandemic of 1918-19 using the technique called reverse genetics and checked the infectious capacity of the newborn virus, it seems that its high pathogenicity may be due to disregulation of the innate immune mechanisms normally performed by the cytokines of host cell. Furthermore, the H5N1 subtype of avian influenza, which also causes a similar dysfunction, has higher pathogenicity than that of 1918-19 influenza virus. Assays to prevent the mild, moderate or severe risks of an eventual future pandemic affecting humans caused by the H5N1 subtype are now being carried out by preparing new vaccines and neuraminidase (= sialidase) inhibitors such as oseltamivir and zanamivir, as well as other agents that block the function of several components of the virus. Recently, has been debated whether it would be convenient to use modulators of the immune system, such as statins, against the secondary effects of the viral infection caused by the disregulation mechanisms of cytokines, to reinforce the above therapeutic measures. The low cost of statins offers additional justification for their use. Reconstruido por ingeniería genética el virus que causó la terrible pandemia de gripe de 1918-19 y comprobada su capacidad de infección, se ha deducido que la gran patogenicidad del mismo puede deberse a una desregulación de los mecanismos inmunitarios que ejercen normalmente citocinas de las células hospedadoras. Asimismo, el subtipo H5N1 del virus de la gripe aviar, por una desregulación análoga, posee una patogenicidad que es aún mayor que la del subtipo de virus de la gripe de 1918-19. Intentos para prevenir los riesgos (leves, moderados o muy graves) de la esperada pandemia que produciría en humanos el subtipo H5N1 -u otros subtipos peligrosos que puedan surgir- se están efectuando con la preparación de nuevas vacunas, así como mediante la interrupción del ciclo biológico del virus con inhibidores de la enzima vírica neuraminidasa (= sialidasa), tales como el oseltamivir y el zanamivir, o con diversos agentes que bloquean el funcionamiento de otros componentes de dicho virus. Últimamente, se está analizando si es o no conveniente tratar de reforzar estas medidas con el uso de moduladores de ciertas citocinas, tales como algunas estatinas u otros compuestos de acción e índole varias, cuyo reducido coste -por pertenecer al grupo de los “genéricos”- constituye un aliciente adicional. Article in Journal/Newspaper Avian flu Real Academia Nacional de Farmacia: Portal Publicaciones |
institution |
Open Polar |
collection |
Real Academia Nacional de Farmacia: Portal Publicaciones |
op_collection_id |
ftranjojs |
language |
Spanish |
topic |
Avian flu; Avian influenza virus; Pathogenicity; Cytokines; Statins; 1918-1919 influenza pandemic; “Spanish flu”; Vaccines against avian flu. Gripe aviar; Influenza aviar; Patogenicidad; Citocinas; Estatinas; Gripe 1918-19; Vacunas anti-gripe aviar. |
spellingShingle |
Avian flu; Avian influenza virus; Pathogenicity; Cytokines; Statins; 1918-1919 influenza pandemic; “Spanish flu”; Vaccines against avian flu. Gripe aviar; Influenza aviar; Patogenicidad; Citocinas; Estatinas; Gripe 1918-19; Vacunas anti-gripe aviar. Cabezas Fernández del Campo, José Antonio Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it |
topic_facet |
Avian flu; Avian influenza virus; Pathogenicity; Cytokines; Statins; 1918-1919 influenza pandemic; “Spanish flu”; Vaccines against avian flu. Gripe aviar; Influenza aviar; Patogenicidad; Citocinas; Estatinas; Gripe 1918-19; Vacunas anti-gripe aviar. |
description |
Since Taubenberger´s team recreated each of the genes of influenza virus that caused the terrible pandemic of 1918-19 using the technique called reverse genetics and checked the infectious capacity of the newborn virus, it seems that its high pathogenicity may be due to disregulation of the innate immune mechanisms normally performed by the cytokines of host cell. Furthermore, the H5N1 subtype of avian influenza, which also causes a similar dysfunction, has higher pathogenicity than that of 1918-19 influenza virus. Assays to prevent the mild, moderate or severe risks of an eventual future pandemic affecting humans caused by the H5N1 subtype are now being carried out by preparing new vaccines and neuraminidase (= sialidase) inhibitors such as oseltamivir and zanamivir, as well as other agents that block the function of several components of the virus. Recently, has been debated whether it would be convenient to use modulators of the immune system, such as statins, against the secondary effects of the viral infection caused by the disregulation mechanisms of cytokines, to reinforce the above therapeutic measures. The low cost of statins offers additional justification for their use. Reconstruido por ingeniería genética el virus que causó la terrible pandemia de gripe de 1918-19 y comprobada su capacidad de infección, se ha deducido que la gran patogenicidad del mismo puede deberse a una desregulación de los mecanismos inmunitarios que ejercen normalmente citocinas de las células hospedadoras. Asimismo, el subtipo H5N1 del virus de la gripe aviar, por una desregulación análoga, posee una patogenicidad que es aún mayor que la del subtipo de virus de la gripe de 1918-19. Intentos para prevenir los riesgos (leves, moderados o muy graves) de la esperada pandemia que produciría en humanos el subtipo H5N1 -u otros subtipos peligrosos que puedan surgir- se están efectuando con la preparación de nuevas vacunas, así como mediante la interrupción del ciclo biológico del virus con inhibidores de la enzima vírica neuraminidasa (= sialidasa), tales como el oseltamivir y el zanamivir, o con diversos agentes que bloquean el funcionamiento de otros componentes de dicho virus. Últimamente, se está analizando si es o no conveniente tratar de reforzar estas medidas con el uso de moduladores de ciertas citocinas, tales como algunas estatinas u otros compuestos de acción e índole varias, cuyo reducido coste -por pertenecer al grupo de los “genéricos”- constituye un aliciente adicional. |
format |
Article in Journal/Newspaper |
author |
Cabezas Fernández del Campo, José Antonio |
author_facet |
Cabezas Fernández del Campo, José Antonio |
author_sort |
Cabezas Fernández del Campo, José Antonio |
title |
Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it |
title_short |
Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it |
title_full |
Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it |
title_fullStr |
Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it |
title_full_unstemmed |
Avian influenza virus: new features related to its pathogenicity and strategies for fighting against it |
title_sort |
avian influenza virus: new features related to its pathogenicity and strategies for fighting against it |
publisher |
Real Academia Nacional de Farmacia |
publishDate |
2009 |
url |
http://www.analesranf.com/index.php/aranf/article/view/935 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
Anales de la Real Academia Nacional de Farmacia; Vol. 75, Núm. 2 (2009) 1697-428X 1697-4271 |
op_relation |
http://www.analesranf.com/index.php/aranf/article/view/935/941 |
_version_ |
1766364842796515328 |