Epidemiology of rare cancers and inequalities in oncologic outcomes
Rare cancers epidemiology is better known compared to the other rare diseases. Thanks to the long history of the European population-based cancer registries and to the EUROCARE huge database, the burden of rare cancers has been estimated the European (EU28) population. A considerable fraction of all...
Published in: | European Journal of Surgical Oncology |
---|---|
Main Author: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2017
|
Subjects: | |
Online Access: | https://pure.qub.ac.uk/en/publications/d46c2682-e624-4d2b-901f-f7c760c61380 https://doi.org/10.1016/j.ejso.2017.08.018 |
id |
ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/d46c2682-e624-4d2b-901f-f7c760c61380 |
---|---|
record_format |
openpolar |
spelling |
ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/d46c2682-e624-4d2b-901f-f7c760c61380 2024-09-15T18:14:35+00:00 Epidemiology of rare cancers and inequalities in oncologic outcomes Gavin, Anna 2017-09-19 https://pure.qub.ac.uk/en/publications/d46c2682-e624-4d2b-901f-f7c760c61380 https://doi.org/10.1016/j.ejso.2017.08.018 eng eng https://pure.qub.ac.uk/en/publications/d46c2682-e624-4d2b-901f-f7c760c61380 info:eu-repo/semantics/closedAccess Gavin , A & RARECAREnet Working Group 2017 , ' Epidemiology of rare cancers and inequalities in oncologic outcomes ' , European Journal of Surgical Oncology . https://doi.org/10.1016/j.ejso.2017.08.018 /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2017 ftqueensubelpubl https://doi.org/10.1016/j.ejso.2017.08.018 2024-07-01T23:47:01Z Rare cancers epidemiology is better known compared to the other rare diseases. Thanks to the long history of the European population-based cancer registries and to the EUROCARE huge database, the burden of rare cancers has been estimated the European (EU28) population. A considerable fraction of all cancers is represented by rare cancers (24%). They are a heterogeneous group of diseases, but they share similar problems: uncertainty of diagnosis, lack of therapies, poor research opportunities, difficulties in clinical trials, lack of expertise and of centres of reference. This paper analyses the major epidemiological indicators of frequency (incidence and prevalence) and outcome (5-year survival) of all rare cancers combined and of selected rare cancers that will be in depth treated in this monographic issue. Source of the results is the RARECAREnet search tool, a database publicly available. Disparities both in incidence and survival, and consequently in prevalence of rare cancers were reported across European countries. Major differences were shown in outcome: 5-year relative survival for all rare cancers together, adjusted by age and case-mix, varied from 55% or more (Italy, Germany, Belgium and Iceland) and less than 40% (Bulgaria, Lithuania and Slovakia). Similarly, for all the analyzed rare cancers, a large survival gap was observed between the Eastern and the Nordic and Central European regions. Dramatic geographical variations were assessed for curable cancers like testicular and non epithelial ovarian cancers. Geographical difference in the annual age-adjusted incidence rates for all rare cancers together varied between >140 per 100,000 (Italy, Scotland, France, Germany, and Switzerland) and <100 (Finland, Portugal, Malta, and Poland). Prevalence, the major indicator of public health resources needs, was about 7-8 times larger than incidence. Most of rare cancers require complex surgical treatment, thus a multidisciplinary approach is essential and treatment should be provided in centres of ... Article in Journal/Newspaper Iceland Queen's University Belfast Research Portal European Journal of Surgical Oncology 45 1 3 11 |
institution |
Open Polar |
collection |
Queen's University Belfast Research Portal |
op_collection_id |
ftqueensubelpubl |
language |
English |
topic |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Gavin, Anna Epidemiology of rare cancers and inequalities in oncologic outcomes |
topic_facet |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
Rare cancers epidemiology is better known compared to the other rare diseases. Thanks to the long history of the European population-based cancer registries and to the EUROCARE huge database, the burden of rare cancers has been estimated the European (EU28) population. A considerable fraction of all cancers is represented by rare cancers (24%). They are a heterogeneous group of diseases, but they share similar problems: uncertainty of diagnosis, lack of therapies, poor research opportunities, difficulties in clinical trials, lack of expertise and of centres of reference. This paper analyses the major epidemiological indicators of frequency (incidence and prevalence) and outcome (5-year survival) of all rare cancers combined and of selected rare cancers that will be in depth treated in this monographic issue. Source of the results is the RARECAREnet search tool, a database publicly available. Disparities both in incidence and survival, and consequently in prevalence of rare cancers were reported across European countries. Major differences were shown in outcome: 5-year relative survival for all rare cancers together, adjusted by age and case-mix, varied from 55% or more (Italy, Germany, Belgium and Iceland) and less than 40% (Bulgaria, Lithuania and Slovakia). Similarly, for all the analyzed rare cancers, a large survival gap was observed between the Eastern and the Nordic and Central European regions. Dramatic geographical variations were assessed for curable cancers like testicular and non epithelial ovarian cancers. Geographical difference in the annual age-adjusted incidence rates for all rare cancers together varied between >140 per 100,000 (Italy, Scotland, France, Germany, and Switzerland) and <100 (Finland, Portugal, Malta, and Poland). Prevalence, the major indicator of public health resources needs, was about 7-8 times larger than incidence. Most of rare cancers require complex surgical treatment, thus a multidisciplinary approach is essential and treatment should be provided in centres of ... |
format |
Article in Journal/Newspaper |
author |
Gavin, Anna |
author_facet |
Gavin, Anna |
author_sort |
Gavin, Anna |
title |
Epidemiology of rare cancers and inequalities in oncologic outcomes |
title_short |
Epidemiology of rare cancers and inequalities in oncologic outcomes |
title_full |
Epidemiology of rare cancers and inequalities in oncologic outcomes |
title_fullStr |
Epidemiology of rare cancers and inequalities in oncologic outcomes |
title_full_unstemmed |
Epidemiology of rare cancers and inequalities in oncologic outcomes |
title_sort |
epidemiology of rare cancers and inequalities in oncologic outcomes |
publishDate |
2017 |
url |
https://pure.qub.ac.uk/en/publications/d46c2682-e624-4d2b-901f-f7c760c61380 https://doi.org/10.1016/j.ejso.2017.08.018 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Gavin , A & RARECAREnet Working Group 2017 , ' Epidemiology of rare cancers and inequalities in oncologic outcomes ' , European Journal of Surgical Oncology . https://doi.org/10.1016/j.ejso.2017.08.018 |
op_relation |
https://pure.qub.ac.uk/en/publications/d46c2682-e624-4d2b-901f-f7c760c61380 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.ejso.2017.08.018 |
container_title |
European Journal of Surgical Oncology |
container_volume |
45 |
container_issue |
1 |
container_start_page |
3 |
op_container_end_page |
11 |
_version_ |
1810452363810439168 |