Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966
Delayed motor developmental milestones have been reported to be associated with schizophrenia in previous studies, but no study has examined the relationship between early motor developmental milestones and schizotypy. We have examined this relationship in a prospective birth cohort.In the Northern...
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Online Access: | https://pure.qub.ac.uk/en/publications/a79e0a54-4564-43fc-8dc1-e4e01738b9a9 https://doi.org/10.1093/schbul/sbx165 https://pureadmin.qub.ac.uk/ws/files/167466942/Motor.pdf |
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ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/a79e0a54-4564-43fc-8dc1-e4e01738b9a9 2024-01-07T09:45:27+01:00 Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 Filatova, Svetlana Koivumaa-Honkanen, H Khandaker, G Lowry, Estelle Nordström, T Hurtig, T Moilanen, K Miettunen, Jouko 2018-08 application/pdf https://pure.qub.ac.uk/en/publications/a79e0a54-4564-43fc-8dc1-e4e01738b9a9 https://doi.org/10.1093/schbul/sbx165 https://pureadmin.qub.ac.uk/ws/files/167466942/Motor.pdf eng eng info:eu-repo/semantics/openAccess Filatova , S , Koivumaa-Honkanen , H , Khandaker , G , Lowry , E , Nordström , T , Hurtig , T , Moilanen , K & Miettunen , J 2018 , ' Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 ' , Schizophrenia Bulletin , vol. 44 , no. 5 , pp. 1151-1158 . https://doi.org/10.1093/schbul/sbx165 article 2018 ftqueensubelpubl https://doi.org/10.1093/schbul/sbx165 2023-12-14T23:22:48Z Delayed motor developmental milestones have been reported to be associated with schizophrenia in previous studies, but no study has examined the relationship between early motor developmental milestones and schizotypy. We have examined this relationship in a prospective birth cohort.In the Northern Finland Birth Cohort 1966, data on 9 early motor developmental milestones were collected prospectively from visits to child welfare centers, and data on adult schizotypy were collected through a questionnaire (N = 4557–4674). Positive schizotypy was measured by the Perceptual Aberration Scale (PAS), negative schizotypy was measured by Physical Anhedonia Scale (PhAS) and Social Anhedonia Scale (SAS). Three related scales were included: Schizoidia Scale (SCHD), Hypomanic Personality Scale (HPS), and Bipolar II Scale (BIP2). We examined the milestone–schizotypy associations before and after excluding cases of schizophrenia from this population-based sample. Hierarchical regression analyses adjusted for covariates and separately for both genders were performed. In men, each extra month of delay in achievement of touching thumb with index finger, sitting unsupported, standing up, walking with support, or walking unsupported was associated with an increase in PAS, PhAS, or SCHD scores, or decrease in BIP2 score (P < .05). In women, each extra month of delay in achievement of turning from back to tummy was associated with an increase in PhAS and SAS scores (P < .05). Schizotypy is associated with delayed motor developmental milestones in early-life, but there is some heterogeneity with regards to types of milestones and gender. These findings suggest delayed motor development confers risk across the continuum of schizophrenia syndrome. Article in Journal/Newspaper Northern Finland Queen's University Belfast Research Portal Thumb ENVELOPE(-64.259,-64.259,-65.247,-65.247) Schizophrenia Bulletin 44 5 1151 1158 |
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Queen's University Belfast Research Portal |
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English |
description |
Delayed motor developmental milestones have been reported to be associated with schizophrenia in previous studies, but no study has examined the relationship between early motor developmental milestones and schizotypy. We have examined this relationship in a prospective birth cohort.In the Northern Finland Birth Cohort 1966, data on 9 early motor developmental milestones were collected prospectively from visits to child welfare centers, and data on adult schizotypy were collected through a questionnaire (N = 4557–4674). Positive schizotypy was measured by the Perceptual Aberration Scale (PAS), negative schizotypy was measured by Physical Anhedonia Scale (PhAS) and Social Anhedonia Scale (SAS). Three related scales were included: Schizoidia Scale (SCHD), Hypomanic Personality Scale (HPS), and Bipolar II Scale (BIP2). We examined the milestone–schizotypy associations before and after excluding cases of schizophrenia from this population-based sample. Hierarchical regression analyses adjusted for covariates and separately for both genders were performed. In men, each extra month of delay in achievement of touching thumb with index finger, sitting unsupported, standing up, walking with support, or walking unsupported was associated with an increase in PAS, PhAS, or SCHD scores, or decrease in BIP2 score (P < .05). In women, each extra month of delay in achievement of turning from back to tummy was associated with an increase in PhAS and SAS scores (P < .05). Schizotypy is associated with delayed motor developmental milestones in early-life, but there is some heterogeneity with regards to types of milestones and gender. These findings suggest delayed motor development confers risk across the continuum of schizophrenia syndrome. |
format |
Article in Journal/Newspaper |
author |
Filatova, Svetlana Koivumaa-Honkanen, H Khandaker, G Lowry, Estelle Nordström, T Hurtig, T Moilanen, K Miettunen, Jouko |
spellingShingle |
Filatova, Svetlana Koivumaa-Honkanen, H Khandaker, G Lowry, Estelle Nordström, T Hurtig, T Moilanen, K Miettunen, Jouko Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 |
author_facet |
Filatova, Svetlana Koivumaa-Honkanen, H Khandaker, G Lowry, Estelle Nordström, T Hurtig, T Moilanen, K Miettunen, Jouko |
author_sort |
Filatova, Svetlana |
title |
Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 |
title_short |
Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 |
title_full |
Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 |
title_fullStr |
Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 |
title_full_unstemmed |
Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 |
title_sort |
early motor developmental milestones and schizotypy in the northern finland birth cohort study 1966 |
publishDate |
2018 |
url |
https://pure.qub.ac.uk/en/publications/a79e0a54-4564-43fc-8dc1-e4e01738b9a9 https://doi.org/10.1093/schbul/sbx165 https://pureadmin.qub.ac.uk/ws/files/167466942/Motor.pdf |
long_lat |
ENVELOPE(-64.259,-64.259,-65.247,-65.247) |
geographic |
Thumb |
geographic_facet |
Thumb |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Filatova , S , Koivumaa-Honkanen , H , Khandaker , G , Lowry , E , Nordström , T , Hurtig , T , Moilanen , K & Miettunen , J 2018 , ' Early Motor Developmental Milestones and Schizotypy in the Northern Finland Birth Cohort Study 1966 ' , Schizophrenia Bulletin , vol. 44 , no. 5 , pp. 1151-1158 . https://doi.org/10.1093/schbul/sbx165 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1093/schbul/sbx165 |
container_title |
Schizophrenia Bulletin |
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44 |
container_issue |
5 |
container_start_page |
1151 |
op_container_end_page |
1158 |
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1787426984392916992 |