Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966
Objective Evidence from randomised controlled trials suggests that vitamin D may reduce multimorbidity, but very few studies have investigated specific determinants of vitamin D2 and D3 (two isoforms of 25-hydroxyvitamin D). The aim of the study was to investigate the determinants of vitamin D2 and...
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ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/6521e7a2-aac1-49d9-8aeb-d3bcfabcba31 2024-05-19T07:45:54+00:00 Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 Palaniswamy, Saranya Hypponen, E Williams, Dylan Jokelainen, Jari Lowry, Estelle Keinanen-kiukaanniemi, Sirkka Herzig, Karl-Heinz Jarvelin, Marjo-Riitta Sebert, Sylvain 2017-03-06 application/pdf https://pure.qub.ac.uk/en/publications/6521e7a2-aac1-49d9-8aeb-d3bcfabcba31 https://doi.org/10.1136/bmjopen-2016-013161 https://pureadmin.qub.ac.uk/ws/files/167468848/e013161.full.pdf eng eng https://pure.qub.ac.uk/en/publications/6521e7a2-aac1-49d9-8aeb-d3bcfabcba31 info:eu-repo/semantics/openAccess Palaniswamy , S , Hypponen , E , Williams , D , Jokelainen , J , Lowry , E , Keinanen-kiukaanniemi , S , Herzig , K-H , Jarvelin , M-R & Sebert , S 2017 , ' Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 ' , BMJ Open , vol. 7 , no. 3 . https://doi.org/10.1136/bmjopen-2016-013161 /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2017 ftqueensubelpubl https://doi.org/10.1136/bmjopen-2016-013161 2024-05-02T00:31:22Z Objective Evidence from randomised controlled trials suggests that vitamin D may reduce multimorbidity, but very few studies have investigated specific determinants of vitamin D2 and D3 (two isoforms of 25-hydroxyvitamin D). The aim of the study was to investigate the determinants of vitamin D2 and D3 and to identify the risk factors associated with hypovitaminosis D. Design Cross-sectional study. Setting Northern Finland Birth Cohort 1966. Participants 2374 male and 2384 female participants with data on serum 25(OH)D2 and 25(OH)D3 concentrations measured at 31 years of age (1997), together with comprehensive measures of daylight, anthropometric, social, lifestyle and contraceptive cofactors. Methods We assessed a wide range of potential determinants prior to a nationwide fortification programme introduced in Finland. The determinants of 25(OH)D2, 25(OH)D3 and 25(OH)D concentrations were analysed by linear regression and risk factors for being in lower tertile of 25(OH)D concentration by ordinal logistic regression. Results At the time of sampling, 72% of the participants were vitamin D sufficient (≥50 nmol/L). Low sunlight exposure period (vs high) was associated positively with 25(OH)D2 and negatively with 25(OH)D3 concentrations. Use of oral contraceptives (vs non-users) was associated with an increase of 0.17 nmol/L (95% CI 0.08 to 0.27) and 0.48 nmol/L (95% CI 0.41 to 0.56) in 25(OH)D2 and 25(OH)D3 concentrations. Sex, season, latitude, alcohol consumption and physical activity were the factors most strongly associated with 25(OH)D concentration. Risk factors for low vitamin D status were low sunlight exposure defined by time of sampling, residing in northern latitudes, obesity, higher waist circumference, low physical activity and unhealthy diet. Conclusions We demonstrate some differential associations of environmental and lifestyle factors with 25(OH)D2 and 25(OH)D3 raising important questions related to personalised healthcare. Future strategies could implement lifestyle modification and supplementation ... Article in Journal/Newspaper Northern Finland Queen's University Belfast Research Portal BMJ Open 7 3 e013161 |
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Queen's University Belfast Research Portal |
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ftqueensubelpubl |
language |
English |
topic |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Palaniswamy, Saranya Hypponen, E Williams, Dylan Jokelainen, Jari Lowry, Estelle Keinanen-kiukaanniemi, Sirkka Herzig, Karl-Heinz Jarvelin, Marjo-Riitta Sebert, Sylvain Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 |
topic_facet |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
Objective Evidence from randomised controlled trials suggests that vitamin D may reduce multimorbidity, but very few studies have investigated specific determinants of vitamin D2 and D3 (two isoforms of 25-hydroxyvitamin D). The aim of the study was to investigate the determinants of vitamin D2 and D3 and to identify the risk factors associated with hypovitaminosis D. Design Cross-sectional study. Setting Northern Finland Birth Cohort 1966. Participants 2374 male and 2384 female participants with data on serum 25(OH)D2 and 25(OH)D3 concentrations measured at 31 years of age (1997), together with comprehensive measures of daylight, anthropometric, social, lifestyle and contraceptive cofactors. Methods We assessed a wide range of potential determinants prior to a nationwide fortification programme introduced in Finland. The determinants of 25(OH)D2, 25(OH)D3 and 25(OH)D concentrations were analysed by linear regression and risk factors for being in lower tertile of 25(OH)D concentration by ordinal logistic regression. Results At the time of sampling, 72% of the participants were vitamin D sufficient (≥50 nmol/L). Low sunlight exposure period (vs high) was associated positively with 25(OH)D2 and negatively with 25(OH)D3 concentrations. Use of oral contraceptives (vs non-users) was associated with an increase of 0.17 nmol/L (95% CI 0.08 to 0.27) and 0.48 nmol/L (95% CI 0.41 to 0.56) in 25(OH)D2 and 25(OH)D3 concentrations. Sex, season, latitude, alcohol consumption and physical activity were the factors most strongly associated with 25(OH)D concentration. Risk factors for low vitamin D status were low sunlight exposure defined by time of sampling, residing in northern latitudes, obesity, higher waist circumference, low physical activity and unhealthy diet. Conclusions We demonstrate some differential associations of environmental and lifestyle factors with 25(OH)D2 and 25(OH)D3 raising important questions related to personalised healthcare. Future strategies could implement lifestyle modification and supplementation ... |
format |
Article in Journal/Newspaper |
author |
Palaniswamy, Saranya Hypponen, E Williams, Dylan Jokelainen, Jari Lowry, Estelle Keinanen-kiukaanniemi, Sirkka Herzig, Karl-Heinz Jarvelin, Marjo-Riitta Sebert, Sylvain |
author_facet |
Palaniswamy, Saranya Hypponen, E Williams, Dylan Jokelainen, Jari Lowry, Estelle Keinanen-kiukaanniemi, Sirkka Herzig, Karl-Heinz Jarvelin, Marjo-Riitta Sebert, Sylvain |
author_sort |
Palaniswamy, Saranya |
title |
Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 |
title_short |
Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 |
title_full |
Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 |
title_fullStr |
Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 |
title_full_unstemmed |
Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 |
title_sort |
potential determinants of vitamin d in finnish adults: a cross-sectional study from the northern finland birth cohort 1966 |
publishDate |
2017 |
url |
https://pure.qub.ac.uk/en/publications/6521e7a2-aac1-49d9-8aeb-d3bcfabcba31 https://doi.org/10.1136/bmjopen-2016-013161 https://pureadmin.qub.ac.uk/ws/files/167468848/e013161.full.pdf |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Palaniswamy , S , Hypponen , E , Williams , D , Jokelainen , J , Lowry , E , Keinanen-kiukaanniemi , S , Herzig , K-H , Jarvelin , M-R & Sebert , S 2017 , ' Potential determinants of vitamin D in Finnish adults: a cross-sectional study from the Northern Finland birth cohort 1966 ' , BMJ Open , vol. 7 , no. 3 . https://doi.org/10.1136/bmjopen-2016-013161 |
op_relation |
https://pure.qub.ac.uk/en/publications/6521e7a2-aac1-49d9-8aeb-d3bcfabcba31 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/bmjopen-2016-013161 |
container_title |
BMJ Open |
container_volume |
7 |
container_issue |
3 |
container_start_page |
e013161 |
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1799486030876770304 |