Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study
PURPOSE: To examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). METHODS: A population-based, cross-sectional study of Caucasians aged 65-87 years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic reg...
Published in: | Acta Ophthalmologica |
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Language: | English |
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2014
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Online Access: | https://pure.qub.ac.uk/en/publications/573f5488-e76a-42e6-8aa1-b5346b13024b https://doi.org/10.1111/aos.12346 |
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ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/573f5488-e76a-42e6-8aa1-b5346b13024b 2024-06-23T07:50:53+00:00 Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger 2014-11 https://pure.qub.ac.uk/en/publications/573f5488-e76a-42e6-8aa1-b5346b13024b https://doi.org/10.1111/aos.12346 eng eng https://pure.qub.ac.uk/en/publications/573f5488-e76a-42e6-8aa1-b5346b13024b info:eu-repo/semantics/closedAccess Erke , M G , Bertelsen , G , Peto , T , Sjølie , A K , Lindekleiv , H & Njølstad , I 2014 , ' Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study ' , Acta Ophthalmologica , vol. 92 , no. 7 , pp. 662-669 . https://doi.org/10.1111/aos.12346 Aged 80 and over Alcohol Drinking Arctic Regions Cardiovascular Diseases Cross-Sectional Studies Female Humans Hypertension Macular Degeneration Male Middle Aged Norway Obesity Overweight Prospective Studies Risk Factors Sedentary Lifestyle Smoking Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2014 ftqueensubelpubl https://doi.org/10.1111/aos.12346 2024-06-11T14:25:40Z PURPOSE: To examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). METHODS: A population-based, cross-sectional study of Caucasians aged 65-87 years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic regression analyses were performed based on questionnaires addressing habits of smoking, alcohol consumption, physical activity, health and medication; and physical examination comprising anthropometric measurements, blood pressure and blood sampling. Cardiovascular disease status was obtained from a validated end-point registry. RESULTS: Gradable photographs were available for 2631 participants, of whom 92 (3.5%) subjects had late AMD. In the multivariable analysis of late AMD, significant interactions were found between sex and the variables age, triglyceride level, use of lipid-lowering drugs and physical exercise. Current daily smoking was significantly related to late AMD in both sexes (odds ratio (OR) 4.06, 95% confidence interval (CI) 1.69-9.76 and OR 3.59, 95% CI 1.17-11.04, women and men, respectively) compared with never smokers. Higher number of pack years was associated with the presence of large drusen (>125 μm) (OR 1.04, 95% CI 1.01-1.09 per 5 years). Higher systolic blood pressure (OR 1.06, 95% CI 1.01-1.12 per 5 mmHg), overweight (OR 2.87, 95% CI 1.13-7.29) and obesity (OR 2.92, 95% CI 1.06-8.03), physical exercise duration (OR 0.41, 95% 0.18-0.96 for 30 min or more compared with less) and frequency (OR 0.46, 95% CI 0.23-0.92 for weekly or more often compared to less) were associated with late AMD in women only. CONCLUSIONS: Smoking was strongly associated with AMD, in line with results from other populations. Also, late AMD was related to higher systolic blood pressure, physical inactivity, overweight and obesity in women. Article in Journal/Newspaper Arctic Tromsø Queen's University Belfast Research Portal Arctic Norway Tromsø Acta Ophthalmologica 92 7 662 669 |
institution |
Open Polar |
collection |
Queen's University Belfast Research Portal |
op_collection_id |
ftqueensubelpubl |
language |
English |
topic |
Aged 80 and over Alcohol Drinking Arctic Regions Cardiovascular Diseases Cross-Sectional Studies Female Humans Hypertension Macular Degeneration Male Middle Aged Norway Obesity Overweight Prospective Studies Risk Factors Sedentary Lifestyle Smoking Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
Aged 80 and over Alcohol Drinking Arctic Regions Cardiovascular Diseases Cross-Sectional Studies Female Humans Hypertension Macular Degeneration Male Middle Aged Norway Obesity Overweight Prospective Studies Risk Factors Sedentary Lifestyle Smoking Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study |
topic_facet |
Aged 80 and over Alcohol Drinking Arctic Regions Cardiovascular Diseases Cross-Sectional Studies Female Humans Hypertension Macular Degeneration Male Middle Aged Norway Obesity Overweight Prospective Studies Risk Factors Sedentary Lifestyle Smoking Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
PURPOSE: To examine associations between cardiovascular risk factors and age-related macular degeneration (AMD). METHODS: A population-based, cross-sectional study of Caucasians aged 65-87 years was conducted in Norway in 2007/2008. Retinal photographs were graded for AMD. Multivariable logistic regression analyses were performed based on questionnaires addressing habits of smoking, alcohol consumption, physical activity, health and medication; and physical examination comprising anthropometric measurements, blood pressure and blood sampling. Cardiovascular disease status was obtained from a validated end-point registry. RESULTS: Gradable photographs were available for 2631 participants, of whom 92 (3.5%) subjects had late AMD. In the multivariable analysis of late AMD, significant interactions were found between sex and the variables age, triglyceride level, use of lipid-lowering drugs and physical exercise. Current daily smoking was significantly related to late AMD in both sexes (odds ratio (OR) 4.06, 95% confidence interval (CI) 1.69-9.76 and OR 3.59, 95% CI 1.17-11.04, women and men, respectively) compared with never smokers. Higher number of pack years was associated with the presence of large drusen (>125 μm) (OR 1.04, 95% CI 1.01-1.09 per 5 years). Higher systolic blood pressure (OR 1.06, 95% CI 1.01-1.12 per 5 mmHg), overweight (OR 2.87, 95% CI 1.13-7.29) and obesity (OR 2.92, 95% CI 1.06-8.03), physical exercise duration (OR 0.41, 95% 0.18-0.96 for 30 min or more compared with less) and frequency (OR 0.46, 95% CI 0.23-0.92 for weekly or more often compared to less) were associated with late AMD in women only. CONCLUSIONS: Smoking was strongly associated with AMD, in line with results from other populations. Also, late AMD was related to higher systolic blood pressure, physical inactivity, overweight and obesity in women. |
format |
Article in Journal/Newspaper |
author |
Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger |
author_facet |
Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger |
author_sort |
Erke, Maja G |
title |
Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study |
title_short |
Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study |
title_full |
Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study |
title_fullStr |
Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study |
title_full_unstemmed |
Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study |
title_sort |
cardiovascular risk factors associated with age-related macular degeneration: the tromsø study |
publishDate |
2014 |
url |
https://pure.qub.ac.uk/en/publications/573f5488-e76a-42e6-8aa1-b5346b13024b https://doi.org/10.1111/aos.12346 |
geographic |
Arctic Norway Tromsø |
geographic_facet |
Arctic Norway Tromsø |
genre |
Arctic Tromsø |
genre_facet |
Arctic Tromsø |
op_source |
Erke , M G , Bertelsen , G , Peto , T , Sjølie , A K , Lindekleiv , H & Njølstad , I 2014 , ' Cardiovascular risk factors associated with age-related macular degeneration: the Tromsø Study ' , Acta Ophthalmologica , vol. 92 , no. 7 , pp. 662-669 . https://doi.org/10.1111/aos.12346 |
op_relation |
https://pure.qub.ac.uk/en/publications/573f5488-e76a-42e6-8aa1-b5346b13024b |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1111/aos.12346 |
container_title |
Acta Ophthalmologica |
container_volume |
92 |
container_issue |
7 |
container_start_page |
662 |
op_container_end_page |
669 |
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1802641831201079296 |