5-year incidence of age-related maculopathy in the Reykjavik Eye Study
PURPOSE: To examine the age- and gender-specific 5-year incidence of age-related maculopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykjavik. DESIGN: Population-based, prospective cohort study. PARTICIPANTS: The cohort was a population-based random sample of citizens 50 yea...
Published in: | Ophthalmology |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2005
|
Subjects: | |
Online Access: | https://pure.qub.ac.uk/en/publications/5057bb3c-4544-49f2-a1e0-addcc4724bdd https://doi.org/10.1016/j.ophtha.2004.07.020 |
id |
ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/5057bb3c-4544-49f2-a1e0-addcc4724bdd |
---|---|
record_format |
openpolar |
spelling |
ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/5057bb3c-4544-49f2-a1e0-addcc4724bdd 2024-05-19T07:42:41+00:00 5-year incidence of age-related maculopathy in the Reykjavik Eye Study Jonasson, Fridbert Arnarsson, Arsaell Peto, Tunde Sasaki, Hiroshi Sasaki, Kazuyuki Bird, Alan C 2005-01 https://pure.qub.ac.uk/en/publications/5057bb3c-4544-49f2-a1e0-addcc4724bdd https://doi.org/10.1016/j.ophtha.2004.07.020 eng eng https://pure.qub.ac.uk/en/publications/5057bb3c-4544-49f2-a1e0-addcc4724bdd info:eu-repo/semantics/restrictedAccess Jonasson , F , Arnarsson , A , Peto , T , Sasaki , H , Sasaki , K & Bird , A C 2005 , ' 5-year incidence of age-related maculopathy in the Reykjavik Eye Study ' , Ophthalmology , vol. 112 , no. 1 , pp. 132-8 . https://doi.org/10.1016/j.ophtha.2004.07.020 Age Distribution Aged 80 and over Cohort Studies Female Humans Iceland Incidence Macular Degeneration Male Middle Aged Population Surveillance Prospective Studies Sex Distribution Journal Article Research Support Non-U.S. Gov't article 2005 ftqueensubelpubl https://doi.org/10.1016/j.ophtha.2004.07.020 2024-05-02T00:26:25Z PURPOSE: To examine the age- and gender-specific 5-year incidence of age-related maculopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykjavik. DESIGN: Population-based, prospective cohort study. PARTICIPANTS: The cohort was a population-based random sample of citizens 50 years and older. Of 1379 eligible subjects, 1045 had a baseline examination in 1996; 846 of the 958 survivors (88.2%) had a 5-year follow-up examination in 2001. METHODS: The incidence of various characteristics of drusen and pigmentary changes that are typical of ARM were determined using the international classification and grading system for ARM and AMD. MAIN OUTCOME MEASURES: Early ARM and AMD were assessed by masked grading of stereo fundus photographs. RESULTS: Hypopigmentation developed at 5 years in 10.7% of people 50 to 59 years of age (95% confidence interval [CI], 6.9-14.4) and in 25.7% those 70 to 79 years of age (95% CI, 18.4-33.0) at baseline. Age-related macular degeneration developed in no one who was 50 to 59 years of age at baseline. Geographic atrophy (GA) developed in 4.6% (95% CI, 1.2-7.9) and exudative AMD in none of those who were 70 years and older at baseline. CONCLUSIONS: Geographic atrophy is the predominant type of AMD in Iceland, and the ratio of GA to neovascular AMD is higher than in racially similar populations. Article in Journal/Newspaper Iceland Queen's University Belfast Research Portal Ophthalmology 112 1 132 138 |
institution |
Open Polar |
collection |
Queen's University Belfast Research Portal |
op_collection_id |
ftqueensubelpubl |
language |
English |
topic |
Age Distribution Aged 80 and over Cohort Studies Female Humans Iceland Incidence Macular Degeneration Male Middle Aged Population Surveillance Prospective Studies Sex Distribution Journal Article Research Support Non-U.S. Gov't |
spellingShingle |
Age Distribution Aged 80 and over Cohort Studies Female Humans Iceland Incidence Macular Degeneration Male Middle Aged Population Surveillance Prospective Studies Sex Distribution Journal Article Research Support Non-U.S. Gov't Jonasson, Fridbert Arnarsson, Arsaell Peto, Tunde Sasaki, Hiroshi Sasaki, Kazuyuki Bird, Alan C 5-year incidence of age-related maculopathy in the Reykjavik Eye Study |
topic_facet |
Age Distribution Aged 80 and over Cohort Studies Female Humans Iceland Incidence Macular Degeneration Male Middle Aged Population Surveillance Prospective Studies Sex Distribution Journal Article Research Support Non-U.S. Gov't |
description |
PURPOSE: To examine the age- and gender-specific 5-year incidence of age-related maculopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykjavik. DESIGN: Population-based, prospective cohort study. PARTICIPANTS: The cohort was a population-based random sample of citizens 50 years and older. Of 1379 eligible subjects, 1045 had a baseline examination in 1996; 846 of the 958 survivors (88.2%) had a 5-year follow-up examination in 2001. METHODS: The incidence of various characteristics of drusen and pigmentary changes that are typical of ARM were determined using the international classification and grading system for ARM and AMD. MAIN OUTCOME MEASURES: Early ARM and AMD were assessed by masked grading of stereo fundus photographs. RESULTS: Hypopigmentation developed at 5 years in 10.7% of people 50 to 59 years of age (95% confidence interval [CI], 6.9-14.4) and in 25.7% those 70 to 79 years of age (95% CI, 18.4-33.0) at baseline. Age-related macular degeneration developed in no one who was 50 to 59 years of age at baseline. Geographic atrophy (GA) developed in 4.6% (95% CI, 1.2-7.9) and exudative AMD in none of those who were 70 years and older at baseline. CONCLUSIONS: Geographic atrophy is the predominant type of AMD in Iceland, and the ratio of GA to neovascular AMD is higher than in racially similar populations. |
format |
Article in Journal/Newspaper |
author |
Jonasson, Fridbert Arnarsson, Arsaell Peto, Tunde Sasaki, Hiroshi Sasaki, Kazuyuki Bird, Alan C |
author_facet |
Jonasson, Fridbert Arnarsson, Arsaell Peto, Tunde Sasaki, Hiroshi Sasaki, Kazuyuki Bird, Alan C |
author_sort |
Jonasson, Fridbert |
title |
5-year incidence of age-related maculopathy in the Reykjavik Eye Study |
title_short |
5-year incidence of age-related maculopathy in the Reykjavik Eye Study |
title_full |
5-year incidence of age-related maculopathy in the Reykjavik Eye Study |
title_fullStr |
5-year incidence of age-related maculopathy in the Reykjavik Eye Study |
title_full_unstemmed |
5-year incidence of age-related maculopathy in the Reykjavik Eye Study |
title_sort |
5-year incidence of age-related maculopathy in the reykjavik eye study |
publishDate |
2005 |
url |
https://pure.qub.ac.uk/en/publications/5057bb3c-4544-49f2-a1e0-addcc4724bdd https://doi.org/10.1016/j.ophtha.2004.07.020 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Jonasson , F , Arnarsson , A , Peto , T , Sasaki , H , Sasaki , K & Bird , A C 2005 , ' 5-year incidence of age-related maculopathy in the Reykjavik Eye Study ' , Ophthalmology , vol. 112 , no. 1 , pp. 132-8 . https://doi.org/10.1016/j.ophtha.2004.07.020 |
op_relation |
https://pure.qub.ac.uk/en/publications/5057bb3c-4544-49f2-a1e0-addcc4724bdd |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.ophtha.2004.07.020 |
container_title |
Ophthalmology |
container_volume |
112 |
container_issue |
1 |
container_start_page |
132 |
op_container_end_page |
138 |
_version_ |
1799482384866869248 |