Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine
Administration of bioactive nutritional supplements near or at the time of immunization has been a recent approach to stimulate human immune response to vaccination. Active hexose correlated compound (AHCC), a mushroom extract, has been shown to protect mice against lethal primary influenza infectio...
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ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/4f6fdbdd-5f0f-4aff-a71c-eea5bbc18f70 2024-06-23T07:51:27+00:00 Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine Roman, Brooke E Beli, Eleni Duriancik, David M Gardner, Elizabeth M 2013-01 https://pure.qub.ac.uk/en/publications/4f6fdbdd-5f0f-4aff-a71c-eea5bbc18f70 https://doi.org/10.1016/j.nutres.2012.11.001 eng eng https://pure.qub.ac.uk/en/publications/4f6fdbdd-5f0f-4aff-a71c-eea5bbc18f70 info:eu-repo/semantics/restrictedAccess Roman , B E , Beli , E , Duriancik , D M & Gardner , E M 2013 , ' Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine ' , Nutrition research (New York, N.Y.) , vol. 33 , no. 1 , pp. 12-7 . https://doi.org/10.1016/j.nutres.2012.11.001 Agaricales/chemistry Antibodies Viral/blood Antibody Formation/drug effects Dietary Supplements Female Humans Influenza B virus/immunology Influenza Vaccines/administration & dosage Influenza Human/prevention & control Lymphocytes/drug effects Male Middle Aged Pilot Projects Polysaccharides/administration & dosage Vaccination /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2013 ftqueensubelpubl https://doi.org/10.1016/j.nutres.2012.11.001 2024-06-04T14:46:02Z Administration of bioactive nutritional supplements near or at the time of immunization has been a recent approach to stimulate human immune response to vaccination. Active hexose correlated compound (AHCC), a mushroom extract, has been shown to protect mice against lethal primary influenza infection. Moreover, when AHCC was administered pre-vaccination in mice, they showed improved protection from lethal avian flu infection when compared to mice vaccinated alone. In this study, we hypothesized that AHCC will also improve the immune responses of healthy individuals to influenza vaccine. A randomized controlled study was performed with 30 healthy adults to evaluate the effects of AHCC supplementation on the immune response to the 2009-2010 seasonal influenza vaccine. Blood was drawn pre-vaccination and 3 wk post-vaccination. Immediately post-vaccination, the AHCC group began supplementation with AHCC (3 g/d). Flow cytometric analysis of lymphocyte subpopulations revealed that AHCC supplementation increased NKT cells (P < .1), and CD8 T cells (P < .05) post-vaccination compared to controls. Analysis of antibody production 3 weeks post-vaccination revealed that AHCC supplementation significantly improved protective antibody titers to influenza B, while the improvement was not significant in the control group. Overall, our study showed that AHCC supplementation improved some lymphocyte percentages and influenza B antibody titers over the control. Future studies are required to determine the kinetics of AHCC supplementation to improve the overall response to influenza vaccination. Article in Journal/Newspaper Avian flu Queen's University Belfast Research Portal Nutrition Research 33 1 12 17 |
institution |
Open Polar |
collection |
Queen's University Belfast Research Portal |
op_collection_id |
ftqueensubelpubl |
language |
English |
topic |
Agaricales/chemistry Antibodies Viral/blood Antibody Formation/drug effects Dietary Supplements Female Humans Influenza B virus/immunology Influenza Vaccines/administration & dosage Influenza Human/prevention & control Lymphocytes/drug effects Male Middle Aged Pilot Projects Polysaccharides/administration & dosage Vaccination /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
Agaricales/chemistry Antibodies Viral/blood Antibody Formation/drug effects Dietary Supplements Female Humans Influenza B virus/immunology Influenza Vaccines/administration & dosage Influenza Human/prevention & control Lymphocytes/drug effects Male Middle Aged Pilot Projects Polysaccharides/administration & dosage Vaccination /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Roman, Brooke E Beli, Eleni Duriancik, David M Gardner, Elizabeth M Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine |
topic_facet |
Agaricales/chemistry Antibodies Viral/blood Antibody Formation/drug effects Dietary Supplements Female Humans Influenza B virus/immunology Influenza Vaccines/administration & dosage Influenza Human/prevention & control Lymphocytes/drug effects Male Middle Aged Pilot Projects Polysaccharides/administration & dosage Vaccination /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
Administration of bioactive nutritional supplements near or at the time of immunization has been a recent approach to stimulate human immune response to vaccination. Active hexose correlated compound (AHCC), a mushroom extract, has been shown to protect mice against lethal primary influenza infection. Moreover, when AHCC was administered pre-vaccination in mice, they showed improved protection from lethal avian flu infection when compared to mice vaccinated alone. In this study, we hypothesized that AHCC will also improve the immune responses of healthy individuals to influenza vaccine. A randomized controlled study was performed with 30 healthy adults to evaluate the effects of AHCC supplementation on the immune response to the 2009-2010 seasonal influenza vaccine. Blood was drawn pre-vaccination and 3 wk post-vaccination. Immediately post-vaccination, the AHCC group began supplementation with AHCC (3 g/d). Flow cytometric analysis of lymphocyte subpopulations revealed that AHCC supplementation increased NKT cells (P < .1), and CD8 T cells (P < .05) post-vaccination compared to controls. Analysis of antibody production 3 weeks post-vaccination revealed that AHCC supplementation significantly improved protective antibody titers to influenza B, while the improvement was not significant in the control group. Overall, our study showed that AHCC supplementation improved some lymphocyte percentages and influenza B antibody titers over the control. Future studies are required to determine the kinetics of AHCC supplementation to improve the overall response to influenza vaccination. |
format |
Article in Journal/Newspaper |
author |
Roman, Brooke E Beli, Eleni Duriancik, David M Gardner, Elizabeth M |
author_facet |
Roman, Brooke E Beli, Eleni Duriancik, David M Gardner, Elizabeth M |
author_sort |
Roman, Brooke E |
title |
Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine |
title_short |
Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine |
title_full |
Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine |
title_fullStr |
Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine |
title_full_unstemmed |
Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine |
title_sort |
short-term supplementation with active hexose correlated compound improves the antibody response to influenza b vaccine |
publishDate |
2013 |
url |
https://pure.qub.ac.uk/en/publications/4f6fdbdd-5f0f-4aff-a71c-eea5bbc18f70 https://doi.org/10.1016/j.nutres.2012.11.001 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
Roman , B E , Beli , E , Duriancik , D M & Gardner , E M 2013 , ' Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine ' , Nutrition research (New York, N.Y.) , vol. 33 , no. 1 , pp. 12-7 . https://doi.org/10.1016/j.nutres.2012.11.001 |
op_relation |
https://pure.qub.ac.uk/en/publications/4f6fdbdd-5f0f-4aff-a71c-eea5bbc18f70 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.nutres.2012.11.001 |
container_title |
Nutrition Research |
container_volume |
33 |
container_issue |
1 |
container_start_page |
12 |
op_container_end_page |
17 |
_version_ |
1802642570286727168 |