Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature
Clathrate hydrates are nonstoichiometric crystalline inclusion compounds. Water acts as a "host lattice"and traps small guest molecules in stable cavities. One example, methane hydrates, are especially prevalent in situ at the seafloor. Although microorganism-produced proteins and polypept...
Published in: | The Journal of Physical Chemistry Letters |
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ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/3b732025-c7fe-4efc-b5e3-4a8f24b5f76e 2024-05-19T07:44:01+00:00 Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature Ghaani, Mohammad Reza Allen, Christopher C.R. Skvortsov, Timofey English, Niall J. 2020-06-17 https://pure.qub.ac.uk/en/publications/3b732025-c7fe-4efc-b5e3-4a8f24b5f76e https://doi.org/10.1021/acs.jpclett.0c01224 eng eng https://pure.qub.ac.uk/en/publications/3b732025-c7fe-4efc-b5e3-4a8f24b5f76e info:eu-repo/semantics/closedAccess Ghaani , M R , Allen , C C R , Skvortsov , T & English , N J 2020 , ' Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature ' , Journal of Physical Chemistry Letters , vol. 11 , no. 13 , pp. 5068–5075 . https://doi.org/10.1021/acs.jpclett.0c01224 /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water article 2020 ftqueensubelpubl https://doi.org/10.1021/acs.jpclett.0c01224 2024-04-25T00:10:31Z Clathrate hydrates are nonstoichiometric crystalline inclusion compounds. Water acts as a "host lattice"and traps small guest molecules in stable cavities. One example, methane hydrates, are especially prevalent in situ at the seafloor. Although microorganism-produced proteins and polypeptides, including marine methylotroph porin proteins, can accelerate methane hydrate formation under conditions simulating their natural occurrence at the seafloor, the role that particular peptide sequences play in biocatalytic hydrate kinetics enhancement is unclear, especially the underlying molecular-level mechanisms. Here, we reveal the peptide-focused regulation of microorganisms' role in managing marine hydrates via an approximation mechanism of enzymatic catalysis accelerating hydrate formation. Aside from control of hydrate kinetics per se, we speculate that this peptide-centric mechanistic understanding could lead to a re-evaluation of the extent and geological importance of bioregulation of methane turnover in the biosphere. Article in Journal/Newspaper Methane hydrate Queen's University Belfast Research Portal The Journal of Physical Chemistry Letters 11 13 5068 5075 |
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Queen's University Belfast Research Portal |
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ftqueensubelpubl |
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English |
topic |
/dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water |
spellingShingle |
/dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water Ghaani, Mohammad Reza Allen, Christopher C.R. Skvortsov, Timofey English, Niall J. Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature |
topic_facet |
/dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water |
description |
Clathrate hydrates are nonstoichiometric crystalline inclusion compounds. Water acts as a "host lattice"and traps small guest molecules in stable cavities. One example, methane hydrates, are especially prevalent in situ at the seafloor. Although microorganism-produced proteins and polypeptides, including marine methylotroph porin proteins, can accelerate methane hydrate formation under conditions simulating their natural occurrence at the seafloor, the role that particular peptide sequences play in biocatalytic hydrate kinetics enhancement is unclear, especially the underlying molecular-level mechanisms. Here, we reveal the peptide-focused regulation of microorganisms' role in managing marine hydrates via an approximation mechanism of enzymatic catalysis accelerating hydrate formation. Aside from control of hydrate kinetics per se, we speculate that this peptide-centric mechanistic understanding could lead to a re-evaluation of the extent and geological importance of bioregulation of methane turnover in the biosphere. |
format |
Article in Journal/Newspaper |
author |
Ghaani, Mohammad Reza Allen, Christopher C.R. Skvortsov, Timofey English, Niall J. |
author_facet |
Ghaani, Mohammad Reza Allen, Christopher C.R. Skvortsov, Timofey English, Niall J. |
author_sort |
Ghaani, Mohammad Reza |
title |
Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature |
title_short |
Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature |
title_full |
Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature |
title_fullStr |
Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature |
title_full_unstemmed |
Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature |
title_sort |
engineering peptides to catalyze and control stabilization of gas hydrates: learning from nature |
publishDate |
2020 |
url |
https://pure.qub.ac.uk/en/publications/3b732025-c7fe-4efc-b5e3-4a8f24b5f76e https://doi.org/10.1021/acs.jpclett.0c01224 |
genre |
Methane hydrate |
genre_facet |
Methane hydrate |
op_source |
Ghaani , M R , Allen , C C R , Skvortsov , T & English , N J 2020 , ' Engineering Peptides to Catalyze and Control Stabilization of Gas Hydrates: Learning from Nature ' , Journal of Physical Chemistry Letters , vol. 11 , no. 13 , pp. 5068–5075 . https://doi.org/10.1021/acs.jpclett.0c01224 |
op_relation |
https://pure.qub.ac.uk/en/publications/3b732025-c7fe-4efc-b5e3-4a8f24b5f76e |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1021/acs.jpclett.0c01224 |
container_title |
The Journal of Physical Chemistry Letters |
container_volume |
11 |
container_issue |
13 |
container_start_page |
5068 |
op_container_end_page |
5075 |
_version_ |
1799483779374383104 |