Lactation, female hormones and age-related macular degeneration:the Tromsø Study
OBJECTIVE: Some risk factors for age-related macular degeneration (AMD) have been shown to act differently in women and men. The present study aims to investigate this disparity by examining associations between female hormones, reproductive history and AMD. METHODS: Women aged 65-87 years were invi...
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ftqueensubelpubl:oai:pure.qub.ac.uk/portal:publications/075350d5-462f-4369-a5c4-a64adfc1de87 2024-09-15T18:39:26+00:00 Lactation, female hormones and age-related macular degeneration:the Tromsø Study Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger 2013-08 https://pure.qub.ac.uk/en/publications/075350d5-462f-4369-a5c4-a64adfc1de87 https://doi.org/10.1136/bjophthalmol-2012-302461 eng eng https://pure.qub.ac.uk/en/publications/075350d5-462f-4369-a5c4-a64adfc1de87 info:eu-repo/semantics/restrictedAccess Erke , M G , Bertelsen , G , Peto , T , Sjølie , A K , Lindekleiv , H & Njølstad , I 2013 , ' Lactation, female hormones and age-related macular degeneration : the Tromsø Study ' , British Journal of Ophthalmology , vol. 97 , no. 8 , pp. 1036-9 . https://doi.org/10.1136/bjophthalmol-2012-302461 Aged 80 and over Breast Feeding Cholesterol Cross-Sectional Studies Diet Female Hemoglobin A Glycosylated Hormone Replacement Therapy Humans Lactation Macular Degeneration Menarche Menopause Norway Photography Reproductive History Retinal Drusen Risk Factors Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't article 2013 ftqueensubelpubl https://doi.org/10.1136/bjophthalmol-2012-302461 2024-07-22T23:44:20Z OBJECTIVE: Some risk factors for age-related macular degeneration (AMD) have been shown to act differently in women and men. The present study aims to investigate this disparity by examining associations between female hormones, reproductive history and AMD. METHODS: Women aged 65-87 years were invited to this cross-sectional, population-based study in Norway. Participants underwent physical examination, retinal photography, answered questionnaires and had blood samples taken. RESULTS: The sample included 1512 women, of whom 48 (3.2%) had late AMD and 378 (25%) had large drusen >125 μm phenotype. Length of breast feeding per child was significantly associated with late AMD (OR per month 0.80, 95% CI 0.68 to 0.94) in multivariable regression analysis. We observed no associations between late AMD or drusen >125 μm and contraceptives, oral hormonal replacement therapy, parity, age at first childbirth, age of menarche, age of menopause, number of menstruating years or the reason for menopause. CONCLUSIONS: Longer duration of lactation was associated with lower frequency of maternal late AMD when controlled for confounders. Other reproductive factors and hormone replacement therapy were not significantly associated with AMD. Article in Journal/Newspaper Tromsø Queen's University Belfast Research Portal British Journal of Ophthalmology 97 8 1036 1039 |
institution |
Open Polar |
collection |
Queen's University Belfast Research Portal |
op_collection_id |
ftqueensubelpubl |
language |
English |
topic |
Aged 80 and over Breast Feeding Cholesterol Cross-Sectional Studies Diet Female Hemoglobin A Glycosylated Hormone Replacement Therapy Humans Lactation Macular Degeneration Menarche Menopause Norway Photography Reproductive History Retinal Drusen Risk Factors Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't |
spellingShingle |
Aged 80 and over Breast Feeding Cholesterol Cross-Sectional Studies Diet Female Hemoglobin A Glycosylated Hormone Replacement Therapy Humans Lactation Macular Degeneration Menarche Menopause Norway Photography Reproductive History Retinal Drusen Risk Factors Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger Lactation, female hormones and age-related macular degeneration:the Tromsø Study |
topic_facet |
Aged 80 and over Breast Feeding Cholesterol Cross-Sectional Studies Diet Female Hemoglobin A Glycosylated Hormone Replacement Therapy Humans Lactation Macular Degeneration Menarche Menopause Norway Photography Reproductive History Retinal Drusen Risk Factors Surveys and Questionnaires Journal Article Research Support Non-U.S. Gov't |
description |
OBJECTIVE: Some risk factors for age-related macular degeneration (AMD) have been shown to act differently in women and men. The present study aims to investigate this disparity by examining associations between female hormones, reproductive history and AMD. METHODS: Women aged 65-87 years were invited to this cross-sectional, population-based study in Norway. Participants underwent physical examination, retinal photography, answered questionnaires and had blood samples taken. RESULTS: The sample included 1512 women, of whom 48 (3.2%) had late AMD and 378 (25%) had large drusen >125 μm phenotype. Length of breast feeding per child was significantly associated with late AMD (OR per month 0.80, 95% CI 0.68 to 0.94) in multivariable regression analysis. We observed no associations between late AMD or drusen >125 μm and contraceptives, oral hormonal replacement therapy, parity, age at first childbirth, age of menarche, age of menopause, number of menstruating years or the reason for menopause. CONCLUSIONS: Longer duration of lactation was associated with lower frequency of maternal late AMD when controlled for confounders. Other reproductive factors and hormone replacement therapy were not significantly associated with AMD. |
format |
Article in Journal/Newspaper |
author |
Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger |
author_facet |
Erke, Maja G Bertelsen, Geir Peto, Tunde Sjølie, Anne K Lindekleiv, Haakon Njølstad, Inger |
author_sort |
Erke, Maja G |
title |
Lactation, female hormones and age-related macular degeneration:the Tromsø Study |
title_short |
Lactation, female hormones and age-related macular degeneration:the Tromsø Study |
title_full |
Lactation, female hormones and age-related macular degeneration:the Tromsø Study |
title_fullStr |
Lactation, female hormones and age-related macular degeneration:the Tromsø Study |
title_full_unstemmed |
Lactation, female hormones and age-related macular degeneration:the Tromsø Study |
title_sort |
lactation, female hormones and age-related macular degeneration:the tromsø study |
publishDate |
2013 |
url |
https://pure.qub.ac.uk/en/publications/075350d5-462f-4369-a5c4-a64adfc1de87 https://doi.org/10.1136/bjophthalmol-2012-302461 |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Erke , M G , Bertelsen , G , Peto , T , Sjølie , A K , Lindekleiv , H & Njølstad , I 2013 , ' Lactation, female hormones and age-related macular degeneration : the Tromsø Study ' , British Journal of Ophthalmology , vol. 97 , no. 8 , pp. 1036-9 . https://doi.org/10.1136/bjophthalmol-2012-302461 |
op_relation |
https://pure.qub.ac.uk/en/publications/075350d5-462f-4369-a5c4-a64adfc1de87 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1136/bjophthalmol-2012-302461 |
container_title |
British Journal of Ophthalmology |
container_volume |
97 |
container_issue |
8 |
container_start_page |
1036 |
op_container_end_page |
1039 |
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1810483814697271296 |