SAV Nsp2 regulates NF-κB signaling to induce inflammatory responses by targeting host DDX3

• Published in: Developmental & Comparative Immunology
• Main Authors: Gao, Shuai, Han, Bing, Xu, Baoxing, Wang, Na, Zhang, Yanru, Liu, Xuefei, Zhang, Mengmeng, Wang, Guanbo, Guan, Xueting, Huang, Jinshan, Liu, Min, Shi, Wen
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2023
• Subjects: Nsp2; Inflammatory responses; DDX3; NF-κB; SAV; Sav’; Atlantic salmon; Salmo salar
• Online Access: https://pure.qub.ac.uk/en/publications/008dfc06-bfdc-41d2-9503-5987dcfc3e15; https://doi.org/10.1016/j.dci.2022.104612

Salmon alphavirus (SAV) infection leads to severe pancreas disease (PD) with typical inflammatory responses in Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). Nsp2, an important nonstructural protein of SAV, can activate NF-κB signaling pathway to reduce inflammatory responses...