Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis
Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon (Salmo salar) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that...
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ftqueensland:oai:eprints.qut.edu.au:241385 2024-02-04T09:58:50+01:00 Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis Klykken, Christine Boissonnot, Lauris Reed, Anne Katrine Whatmore, Paul Attramadal, Kari Olsen, Rolf Erik 2022-11 https://eprints.qut.edu.au/241385/ unknown Wiley-Blackwell Publishing Ltd doi:10.1111/jfd.13687 Klykken, Christine, Boissonnot, Lauris, Reed, Anne Katrine, Whatmore, Paul, Attramadal, Kari, & Olsen, Rolf Erik (2022) Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis. Journal of Fish Diseases, 45(11), pp. 1645-1658. https://eprints.qut.edu.au/241385/ Academic Division 2022 The Authors This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au Journal of Fish Diseases Atlantic salmon kidney malfunction nephrocalcinosis RNA seq Contribution to Journal 2022 ftqueensland https://doi.org/10.1111/jfd.13687 2024-01-09T00:13:16Z Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon (Salmo salar) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that numerous genes are differentially expressed in fish with NC compared with healthy salmon. The most evident changes in gene expression patterns in the NC group were a massive downregulation of metabolism and energy production, upregulation of signalling pathways important for tissue repair and function maintenance and upregulation of inflammatory responses. Overall, the extensive tissue damage and the gene regulation responses that affect salmon with severe nephrocalcinosis are highly likely to have dramatic consequences on fish survival. Article in Journal/Newspaper Atlantic salmon Salmo salar Queensland University of Technology: QUT ePrints Journal of Fish Diseases 45 11 1645 1658 |
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Open Polar |
collection |
Queensland University of Technology: QUT ePrints |
op_collection_id |
ftqueensland |
language |
unknown |
topic |
Atlantic salmon kidney malfunction nephrocalcinosis RNA seq |
spellingShingle |
Atlantic salmon kidney malfunction nephrocalcinosis RNA seq Klykken, Christine Boissonnot, Lauris Reed, Anne Katrine Whatmore, Paul Attramadal, Kari Olsen, Rolf Erik Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis |
topic_facet |
Atlantic salmon kidney malfunction nephrocalcinosis RNA seq |
description |
Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon (Salmo salar) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that numerous genes are differentially expressed in fish with NC compared with healthy salmon. The most evident changes in gene expression patterns in the NC group were a massive downregulation of metabolism and energy production, upregulation of signalling pathways important for tissue repair and function maintenance and upregulation of inflammatory responses. Overall, the extensive tissue damage and the gene regulation responses that affect salmon with severe nephrocalcinosis are highly likely to have dramatic consequences on fish survival. |
format |
Article in Journal/Newspaper |
author |
Klykken, Christine Boissonnot, Lauris Reed, Anne Katrine Whatmore, Paul Attramadal, Kari Olsen, Rolf Erik |
author_facet |
Klykken, Christine Boissonnot, Lauris Reed, Anne Katrine Whatmore, Paul Attramadal, Kari Olsen, Rolf Erik |
author_sort |
Klykken, Christine |
title |
Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis |
title_short |
Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis |
title_full |
Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis |
title_fullStr |
Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis |
title_full_unstemmed |
Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis |
title_sort |
gene expression patterns in atlantic salmon (salmo salar) with severe nephrocalcinosis |
publisher |
Wiley-Blackwell Publishing Ltd |
publishDate |
2022 |
url |
https://eprints.qut.edu.au/241385/ |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Journal of Fish Diseases |
op_relation |
doi:10.1111/jfd.13687 Klykken, Christine, Boissonnot, Lauris, Reed, Anne Katrine, Whatmore, Paul, Attramadal, Kari, & Olsen, Rolf Erik (2022) Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis. Journal of Fish Diseases, 45(11), pp. 1645-1658. https://eprints.qut.edu.au/241385/ Academic Division |
op_rights |
2022 The Authors This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
op_doi |
https://doi.org/10.1111/jfd.13687 |
container_title |
Journal of Fish Diseases |
container_volume |
45 |
container_issue |
11 |
container_start_page |
1645 |
op_container_end_page |
1658 |
_version_ |
1789963412344668160 |