Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study.
Background: Spirometric lung function impairment is an independent predictor of respiratory and cardiovascular disease, and mortality across a broad range of socioeconomic backgrounds and environmental settings. No contemporary studies have explored these relationships in a predominantly regional/re...
Published in: | The Lancet Regional Health - Western Pacific |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
Elsevier Ltd.
2021
|
Subjects: | |
Online Access: | https://eprints.qut.edu.au/229342/ |
id |
ftqueensland:oai:eprints.qut.edu.au:229342 |
---|---|
record_format |
openpolar |
spelling |
ftqueensland:oai:eprints.qut.edu.au:229342 2024-04-28T08:18:50+00:00 Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. Collaro, Andrew J. Chang, Anne B. Marchant, Julie M. Chatfield, Mark D. Dent, Annette Blake, Tamara Mawn, Patsi Fong, Kwun McElrea, Margaret S. 2021-08 application/pdf https://eprints.qut.edu.au/229342/ unknown Elsevier Ltd. https://eprints.qut.edu.au/229342/1/107690328.pdf doi:10.1016/j.lanwpc.2021.100188 Collaro, Andrew J., Chang, Anne B., Marchant, Julie M., Chatfield, Mark D., Dent, Annette, Blake, Tamara, Mawn, Patsi, Fong, Kwun, & McElrea, Margaret S. (2021) Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. The Lancet Regional Health - Western Pacific, 13, Article number: 100188. https://eprints.qut.edu.au/229342/ Centre for Healthcare Transformation; Australian Centre for Health Services Innovation; Faculty of Health; School of Public Health & Social Work free_to_read http://creativecommons.org/licenses/by-nc-nd/4.0/ 2021 The Authors This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au The Lancet Regional Health - Western Pacific Cardiovascular Disease First Nations lung function Outcomes Respiratory Medicine spirometry Contribution to Journal 2021 ftqueensland https://doi.org/10.1016/j.lanwpc.2021.100188 2024-04-03T15:45:52Z Background: Spirometric lung function impairment is an independent predictor of respiratory and cardiovascular disease, and mortality across a broad range of socioeconomic backgrounds and environmental settings. No contemporary studies have explored these relationships in a predominantly regional/remote First Nations population, whose health outcomes are worse than for non-First Nations populations, and First Nations people living in urban centres. Methods: This was a retrospective cohort study of 1,734 adults (1,113 First Nations) referred to specialist respiratory outreach clinics in the state of Queensland, Australia from February 2012 to March 2020. Regression modelling was used to test associations between lung function and mortality and cardiovascular disease. Findings: At the time of analysis (August 2020), 189 patients had died: 88 (47%) from respiratory causes and 38 (20%) from cardiovascular causes. When compared to patients with forced expiratory volume in one second (FEV 1 ) and forced vital capacity (FVC) Z-scores of >0 to -1, patients with Z-scores <-1 were at elevated mortality risk (HR=3•2, 95%CI 1•4-7•4; HR=2•6, 95%CI 1•3-5•1), and elevated cardiovascular disease risk (OR=1•5, 95%CI 1•1-2•2; OR=1•6, 95%CI 1•2-2•3). FEV 1 /FVC% Z-scores <-1 were associated with increased overall mortality (HR=1•6, 95%CI 1•1-2•3), but not cardiovascular disease (OR=1•1, 95%CI 0•8-1•4). These associations were not affected by First Nations status. Interpretation: Reduced lung function even within the clinically normal range is associated with increased mortality, and cardiovascular disease in First Nations Australians. These findings highlight the importance of lung function optimisation and inform the need for future investment to improve outcomes in First Nations populations. Funding: None. Article in Journal/Newspaper First Nations Queensland University of Technology: QUT ePrints The Lancet Regional Health - Western Pacific 13 100188 |
institution |
Open Polar |
collection |
Queensland University of Technology: QUT ePrints |
op_collection_id |
ftqueensland |
language |
unknown |
topic |
Cardiovascular Disease First Nations lung function Outcomes Respiratory Medicine spirometry |
spellingShingle |
Cardiovascular Disease First Nations lung function Outcomes Respiratory Medicine spirometry Collaro, Andrew J. Chang, Anne B. Marchant, Julie M. Chatfield, Mark D. Dent, Annette Blake, Tamara Mawn, Patsi Fong, Kwun McElrea, Margaret S. Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. |
topic_facet |
Cardiovascular Disease First Nations lung function Outcomes Respiratory Medicine spirometry |
description |
Background: Spirometric lung function impairment is an independent predictor of respiratory and cardiovascular disease, and mortality across a broad range of socioeconomic backgrounds and environmental settings. No contemporary studies have explored these relationships in a predominantly regional/remote First Nations population, whose health outcomes are worse than for non-First Nations populations, and First Nations people living in urban centres. Methods: This was a retrospective cohort study of 1,734 adults (1,113 First Nations) referred to specialist respiratory outreach clinics in the state of Queensland, Australia from February 2012 to March 2020. Regression modelling was used to test associations between lung function and mortality and cardiovascular disease. Findings: At the time of analysis (August 2020), 189 patients had died: 88 (47%) from respiratory causes and 38 (20%) from cardiovascular causes. When compared to patients with forced expiratory volume in one second (FEV 1 ) and forced vital capacity (FVC) Z-scores of >0 to -1, patients with Z-scores <-1 were at elevated mortality risk (HR=3•2, 95%CI 1•4-7•4; HR=2•6, 95%CI 1•3-5•1), and elevated cardiovascular disease risk (OR=1•5, 95%CI 1•1-2•2; OR=1•6, 95%CI 1•2-2•3). FEV 1 /FVC% Z-scores <-1 were associated with increased overall mortality (HR=1•6, 95%CI 1•1-2•3), but not cardiovascular disease (OR=1•1, 95%CI 0•8-1•4). These associations were not affected by First Nations status. Interpretation: Reduced lung function even within the clinically normal range is associated with increased mortality, and cardiovascular disease in First Nations Australians. These findings highlight the importance of lung function optimisation and inform the need for future investment to improve outcomes in First Nations populations. Funding: None. |
format |
Article in Journal/Newspaper |
author |
Collaro, Andrew J. Chang, Anne B. Marchant, Julie M. Chatfield, Mark D. Dent, Annette Blake, Tamara Mawn, Patsi Fong, Kwun McElrea, Margaret S. |
author_facet |
Collaro, Andrew J. Chang, Anne B. Marchant, Julie M. Chatfield, Mark D. Dent, Annette Blake, Tamara Mawn, Patsi Fong, Kwun McElrea, Margaret S. |
author_sort |
Collaro, Andrew J. |
title |
Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. |
title_short |
Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. |
title_full |
Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. |
title_fullStr |
Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. |
title_full_unstemmed |
Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. |
title_sort |
associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly first nations population: a cohort study. |
publisher |
Elsevier Ltd. |
publishDate |
2021 |
url |
https://eprints.qut.edu.au/229342/ |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
The Lancet Regional Health - Western Pacific |
op_relation |
https://eprints.qut.edu.au/229342/1/107690328.pdf doi:10.1016/j.lanwpc.2021.100188 Collaro, Andrew J., Chang, Anne B., Marchant, Julie M., Chatfield, Mark D., Dent, Annette, Blake, Tamara, Mawn, Patsi, Fong, Kwun, & McElrea, Margaret S. (2021) Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. The Lancet Regional Health - Western Pacific, 13, Article number: 100188. https://eprints.qut.edu.au/229342/ Centre for Healthcare Transformation; Australian Centre for Health Services Innovation; Faculty of Health; School of Public Health & Social Work |
op_rights |
free_to_read http://creativecommons.org/licenses/by-nc-nd/4.0/ 2021 The Authors This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
op_doi |
https://doi.org/10.1016/j.lanwpc.2021.100188 |
container_title |
The Lancet Regional Health - Western Pacific |
container_volume |
13 |
container_start_page |
100188 |
_version_ |
1797582613807890432 |