Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults

Background: Some but not all previous studies report that pneumonia in children aged less than five years is associated with lower lung function and elevated risk of respiratory disease. To date, none have explored these associations in at-risk populations such as First Nations Australians, whose in...

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Published in:Journal of Clinical Medicine
Main Authors: Collaro, Andrew J., Chang, Anne B., Marchant, Julie M., Chatfield, Mark D., Vicendese, Don, Blake, Tamara L., McElrea, Margaret S., Dharmage, Shyamali C.
Format: Article in Journal/Newspaper
Language:unknown
Published: MDPI AG 2021
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Online Access:https://eprints.qut.edu.au/229324/
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spelling ftqueensland:oai:eprints.qut.edu.au:229324 2024-04-28T08:18:58+00:00 Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults Collaro, Andrew J. Chang, Anne B. Marchant, Julie M. Chatfield, Mark D. Vicendese, Don Blake, Tamara L. McElrea, Margaret S. Dharmage, Shyamali C. 2021-12-01 application/pdf https://eprints.qut.edu.au/229324/ unknown MDPI AG https://eprints.qut.edu.au/229324/1/108014815.pdf doi:10.3390/jcm10245727 Collaro, Andrew J., Chang, Anne B., Marchant, Julie M., Chatfield, Mark D., Vicendese, Don, Blake, Tamara L., McElrea, Margaret S., & Dharmage, Shyamali C. (2021) Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults. Journal of Clinical Medicine, 10(24), Article number: 5727. http://purl.org/au-research/grants/nhmrc/1170958 http://purl.org/au-research/grants/nhmrc/2003334 https://eprints.qut.edu.au/229324/ Centre for Healthcare Transformation; Australian Centre for Health Services Innovation; Faculty of Health; School of Public Health & Social Work free_to_read http://creativecommons.org/licenses/by/4.0/ 2021 The Author(s) This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au Journal of Clinical Medicine Early childhood Lrti Pneumonia Respiratory tract infection Spirometry Contribution to Journal 2021 ftqueensland https://doi.org/10.3390/jcm10245727 2024-04-03T15:45:52Z Background: Some but not all previous studies report that pneumonia in children aged less than five years is associated with lower lung function and elevated risk of respiratory disease. To date, none have explored these associations in at-risk populations such as First Nations Australians, whose incidence of early childhood pneumonia is among the highest reported in the world. Methods: This cross-sectional study included 1276 First Nations Australian children/young adults aged 5–25 years recruited from regional/remote Queensland and Northern Territory communities and schools. Associations between pneumonia and both spirometry values and asthma were investigated using linear and logistic regression. Results: Early childhood pneumonia was associated with lower FEV1 and FVC Z-scores, but not FEV1/FVC% Z-scores, when occurring before age three (FEV1 β = −0.42, [95%CI −0.79, −0.04]; FVC β = −0.62, [95%CI −1.14, −0.09]), and between three and five years (β = −0.50, [95%CI −0.88, −0.12]; β = −0.63, [95%CI −1.17, −0.10]), compared to those who never had pneumonia. Similarly, pneumonia occurring when aged before age three years (OR = 3.68, 95%CI 1.96–6.93) and three to five years (OR = 4.81, 95%CI 1.46–15.8) was associated with increased risk of asthma in later childhood. Conclusions: Early childhood pneumonia is associated with lung function deficits and increased asthma risk in later childhood/early adulthood in First Nations Australians. The disproportionate impact of pneumonia on at-risk children must be addressed as a priority. Article in Journal/Newspaper First Nations Queensland University of Technology: QUT ePrints Journal of Clinical Medicine 10 24 5727
institution Open Polar
collection Queensland University of Technology: QUT ePrints
op_collection_id ftqueensland
language unknown
topic Early childhood
Lrti
Pneumonia
Respiratory tract infection
Spirometry
spellingShingle Early childhood
Lrti
Pneumonia
Respiratory tract infection
Spirometry
Collaro, Andrew J.
Chang, Anne B.
Marchant, Julie M.
Chatfield, Mark D.
Vicendese, Don
Blake, Tamara L.
McElrea, Margaret S.
Dharmage, Shyamali C.
Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
topic_facet Early childhood
Lrti
Pneumonia
Respiratory tract infection
Spirometry
description Background: Some but not all previous studies report that pneumonia in children aged less than five years is associated with lower lung function and elevated risk of respiratory disease. To date, none have explored these associations in at-risk populations such as First Nations Australians, whose incidence of early childhood pneumonia is among the highest reported in the world. Methods: This cross-sectional study included 1276 First Nations Australian children/young adults aged 5–25 years recruited from regional/remote Queensland and Northern Territory communities and schools. Associations between pneumonia and both spirometry values and asthma were investigated using linear and logistic regression. Results: Early childhood pneumonia was associated with lower FEV1 and FVC Z-scores, but not FEV1/FVC% Z-scores, when occurring before age three (FEV1 β = −0.42, [95%CI −0.79, −0.04]; FVC β = −0.62, [95%CI −1.14, −0.09]), and between three and five years (β = −0.50, [95%CI −0.88, −0.12]; β = −0.63, [95%CI −1.17, −0.10]), compared to those who never had pneumonia. Similarly, pneumonia occurring when aged before age three years (OR = 3.68, 95%CI 1.96–6.93) and three to five years (OR = 4.81, 95%CI 1.46–15.8) was associated with increased risk of asthma in later childhood. Conclusions: Early childhood pneumonia is associated with lung function deficits and increased asthma risk in later childhood/early adulthood in First Nations Australians. The disproportionate impact of pneumonia on at-risk children must be addressed as a priority.
format Article in Journal/Newspaper
author Collaro, Andrew J.
Chang, Anne B.
Marchant, Julie M.
Chatfield, Mark D.
Vicendese, Don
Blake, Tamara L.
McElrea, Margaret S.
Dharmage, Shyamali C.
author_facet Collaro, Andrew J.
Chang, Anne B.
Marchant, Julie M.
Chatfield, Mark D.
Vicendese, Don
Blake, Tamara L.
McElrea, Margaret S.
Dharmage, Shyamali C.
author_sort Collaro, Andrew J.
title Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
title_short Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
title_full Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
title_fullStr Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
title_full_unstemmed Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
title_sort early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults
publisher MDPI AG
publishDate 2021
url https://eprints.qut.edu.au/229324/
genre First Nations
genre_facet First Nations
op_source Journal of Clinical Medicine
op_relation https://eprints.qut.edu.au/229324/1/108014815.pdf
doi:10.3390/jcm10245727
Collaro, Andrew J., Chang, Anne B., Marchant, Julie M., Chatfield, Mark D., Vicendese, Don, Blake, Tamara L., McElrea, Margaret S., & Dharmage, Shyamali C. (2021) Early childhood pneumonia is associated with reduced lung function and asthma in first nations australian children and young adults. Journal of Clinical Medicine, 10(24), Article number: 5727.
http://purl.org/au-research/grants/nhmrc/1170958
http://purl.org/au-research/grants/nhmrc/2003334
https://eprints.qut.edu.au/229324/
Centre for Healthcare Transformation; Australian Centre for Health Services Innovation; Faculty of Health; School of Public Health & Social Work
op_rights free_to_read
http://creativecommons.org/licenses/by/4.0/
2021 The Author(s)
This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
op_doi https://doi.org/10.3390/jcm10245727
container_title Journal of Clinical Medicine
container_volume 10
container_issue 24
container_start_page 5727
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