Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia
Background: Although the burden of bronchiectasis is recognized globally, pediatric data are limited, particularly on trends over the years. Also, no published data exists regarding whether vitamin D deficiency or insufficiency and human T-cell lymphotropic virus type 1 (HTLV-1) infection, both foun...
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American College of Chest Physicians
2021
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ftqueensland:oai:eprints.qut.edu.au:229305 2024-05-12T08:03:37+00:00 Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia McCallum, Gabrielle B. Oguoma, Victor M. Versteegh, Lesley A. Wilson, Cate A. Bauert, Paul Spain, Brian Chang, Anne B. 2021-10 https://eprints.qut.edu.au/229305/ unknown American College of Chest Physicians doi:10.1016/j.chest.2021.04.057 McCallum, Gabrielle B., Oguoma, Victor M., Versteegh, Lesley A., Wilson, Cate A., Bauert, Paul, Spain, Brian, & Chang, Anne B. (2021) Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia. Chest, 160(4), pp. 1200-1210. http://purl.org/au-research/grants/nhmrc/1042601 https://eprints.qut.edu.au/229305/ Centre for Healthcare Transformation; Australian Centre for Health Services Innovation; Faculty of Health; School of Public Health & Social Work 2021 American College of Chest Physicians This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au Chest bronchiectasis children chronic suppurative lung disease HTLV-1 vitamin d Contribution to Journal 2021 ftqueensland https://doi.org/10.1016/j.chest.2021.04.057 2024-04-17T14:36:38Z Background: Although the burden of bronchiectasis is recognized globally, pediatric data are limited, particularly on trends over the years. Also, no published data exists regarding whether vitamin D deficiency or insufficiency and human T-cell lymphotropic virus type 1 (HTLV-1) infection, both found to be related to severe bronchiectasis in First Nations adults, also are important in children with bronchiectasis. Research Question: Among children with bronchiectasis, (1) have the clinical and BAL profiles changed between two 5-year periods (period 1, 2007-2011; period 2, 2012-2016) and (b) are vitamin D deficiency or insufficiency, HTLV-1 infection, or both associated with radiologic severity of bronchiectasis? Study Design and Methods: We analyzed the data from children with bronchiectasis prospectively enrolled at Royal Darwin Hospital, Australia, at the first diagnosis; that is, no child was included in both periods. Data collected include demographics, BAL, routine investigation bloods, and high-resolution CT scan of the chest evaluated using the Bhalla and modified Bhalla scores. Results: The median age of the 299 children was 2.2 years (interquartile range, 1.5-3.7 years). One hundred sixty-eight (56%) were male and most were First Nations (92%). Overall, bronchiectasis was high over time, particularly among First Nations children. In the later period, numbers of non-First Nations children more than tripled, but did not reach statistical significance. In period 2 compared with period 1, fewer First Nations children demonstrated chronic cough (period 1, 61%; period 2, 47%; P =.03), and were younger, First Nations children were less likely to have received azithromycin (period 1, 42%; period 2, 21%; P <.001), and the BAL fluid of First Nations children showed lower Haemophilus influenzae and Moraxella catarrhalis infection. HTLV-1 infection was not detected, and vitamin D deficiency or insufficiency did not correlate with severity of bronchiectasis. Interpretation: Bronchiectasis remains high ... Article in Journal/Newspaper First Nations Queensland University of Technology: QUT ePrints Chest 160 4 1200 1210 |
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Queensland University of Technology: QUT ePrints |
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bronchiectasis children chronic suppurative lung disease HTLV-1 vitamin d |
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bronchiectasis children chronic suppurative lung disease HTLV-1 vitamin d McCallum, Gabrielle B. Oguoma, Victor M. Versteegh, Lesley A. Wilson, Cate A. Bauert, Paul Spain, Brian Chang, Anne B. Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia |
topic_facet |
bronchiectasis children chronic suppurative lung disease HTLV-1 vitamin d |
description |
Background: Although the burden of bronchiectasis is recognized globally, pediatric data are limited, particularly on trends over the years. Also, no published data exists regarding whether vitamin D deficiency or insufficiency and human T-cell lymphotropic virus type 1 (HTLV-1) infection, both found to be related to severe bronchiectasis in First Nations adults, also are important in children with bronchiectasis. Research Question: Among children with bronchiectasis, (1) have the clinical and BAL profiles changed between two 5-year periods (period 1, 2007-2011; period 2, 2012-2016) and (b) are vitamin D deficiency or insufficiency, HTLV-1 infection, or both associated with radiologic severity of bronchiectasis? Study Design and Methods: We analyzed the data from children with bronchiectasis prospectively enrolled at Royal Darwin Hospital, Australia, at the first diagnosis; that is, no child was included in both periods. Data collected include demographics, BAL, routine investigation bloods, and high-resolution CT scan of the chest evaluated using the Bhalla and modified Bhalla scores. Results: The median age of the 299 children was 2.2 years (interquartile range, 1.5-3.7 years). One hundred sixty-eight (56%) were male and most were First Nations (92%). Overall, bronchiectasis was high over time, particularly among First Nations children. In the later period, numbers of non-First Nations children more than tripled, but did not reach statistical significance. In period 2 compared with period 1, fewer First Nations children demonstrated chronic cough (period 1, 61%; period 2, 47%; P =.03), and were younger, First Nations children were less likely to have received azithromycin (period 1, 42%; period 2, 21%; P <.001), and the BAL fluid of First Nations children showed lower Haemophilus influenzae and Moraxella catarrhalis infection. HTLV-1 infection was not detected, and vitamin D deficiency or insufficiency did not correlate with severity of bronchiectasis. Interpretation: Bronchiectasis remains high ... |
format |
Article in Journal/Newspaper |
author |
McCallum, Gabrielle B. Oguoma, Victor M. Versteegh, Lesley A. Wilson, Cate A. Bauert, Paul Spain, Brian Chang, Anne B. |
author_facet |
McCallum, Gabrielle B. Oguoma, Victor M. Versteegh, Lesley A. Wilson, Cate A. Bauert, Paul Spain, Brian Chang, Anne B. |
author_sort |
McCallum, Gabrielle B. |
title |
Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia |
title_short |
Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia |
title_full |
Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia |
title_fullStr |
Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia |
title_full_unstemmed |
Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia |
title_sort |
comparison of profiles of first nations and non-first nations children with bronchiectasis over two 5-year periods in the northern territory, australia |
publisher |
American College of Chest Physicians |
publishDate |
2021 |
url |
https://eprints.qut.edu.au/229305/ |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Chest |
op_relation |
doi:10.1016/j.chest.2021.04.057 McCallum, Gabrielle B., Oguoma, Victor M., Versteegh, Lesley A., Wilson, Cate A., Bauert, Paul, Spain, Brian, & Chang, Anne B. (2021) Comparison of Profiles of First Nations and Non-First Nations Children With Bronchiectasis Over Two 5-Year Periods in the Northern Territory, Australia. Chest, 160(4), pp. 1200-1210. http://purl.org/au-research/grants/nhmrc/1042601 https://eprints.qut.edu.au/229305/ Centre for Healthcare Transformation; Australian Centre for Health Services Innovation; Faculty of Health; School of Public Health & Social Work |
op_rights |
2021 American College of Chest Physicians This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
op_doi |
https://doi.org/10.1016/j.chest.2021.04.057 |
container_title |
Chest |
container_volume |
160 |
container_issue |
4 |
container_start_page |
1200 |
op_container_end_page |
1210 |
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