Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region with Cortical and Subcortical Morphology and Cognition

• Published in: JAMA Psychiatry
• Main Authors: Van Der Meer, Dennis, Sonderby, Ida E., Kaufmann, Tobias, Walters, G. Bragi, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Micael, Armstrong, Nicola J., Bernard, Manon, Blackburn, Nicholas B., Blangero, John, Boomsma, Dorret I., Brodaty, Henry, Brouwer, Rachel M., Bulow, Robin, Cahn, Wiepke, Calhoun, Vince D., Caspers, Svenja, Cavalleri, Gianpiero L., Ching, Christopher R.K., Cichon, Sven, Ciufolini, Simone, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E., Dalvie, Shareefa, Dazzan, Paola, De Geus, Eco J.C., De Zubicaray, Greig I., De Zwarte, Sonja M.C., Delanty, Norman, Den Braber, Anouk, Desrivieres, Sylvane, Di Forti, Marta, Doherty, Joanne L., Donohoe, Gary, Ehrlich, Stefan, Eising, Else, Espeseth, Thomas, Fisher, Simon E., Fladby, Tormod, Frei, Oleksandr, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Glahn, David C., Grabe, Hans J., Groenewold, Nynke A., Gústafsson, Ómar, Haavik, Jan, Haberg, Asta K., Hashimoto, Ryota, Hehir-Kwa, Jayne Y., Hibar, Derrek P., Hillegers, Manon H.J., Hoffmann, Per, Holleran, Laurena, Hottenga, Jouke Jan, Hulshoff Pol, Hilleke E., Ikeda, Masashi, Jacquemont, Sébastien, Jahanshad, Neda, Jockwitz, Christiane, Johansson, Stefan, Jönsson, Erik G., Kikuchi, Masataka, Knowles, Emma E.M., Kwok, John B., Le Hellard, Stephanie, Linden, David E.J., Liu, Jingyu, Lundervold, Arvid, Lundervold, Astri J., Martin, Nicholas G., Mather, Karen A., Mathias, Samuel R., McMahon, Katie L., McRae, Allan F., Medland, Sarah E., Moberget, Torgeir, Moreau, Clara, Morris, Derek W., Mühleisen, Thomas W., Murray, Robin M., Nordvik, Jan E., Nyberg, Lars, Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Michael J., Paus, Tomas, Pausova, Zdenka, Peralta, Juan M., Pike, Bruce, Prieto, Carlos, Quinlan, Erin Burke, Reinbold, Céline S., Reis Marques, Tiago, Rucker, James J.H., Sachdev, Perminder S., Sando, Sigrid B., Schofield, Peter R., Schork, Andrew J., Schumann, Gunter, Shin, Jean, Shumskaya, Elena, Silva, Ana I., Sisodiya, Sanjay M., Steen, Vidar M., Stein, Dan J., Strike, Lachlan T., Tamnes, Christian K., Teumer, Alexander, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, Uhlmann, Anne, Úlfarsson, Magnús, Van 'T Ent, Dennis, Van Den Bree, Marianne B.M., Vassos, Evangelos, Wen, Wei, Wittfeld, Katharina, Wright, Margaret J., Zayats, Tetyana, Dale, Anders M., Djurovic, Srdjan, Agartz, Ingrid, Westlye, Lars T., Stefánsson, Hreinn, Stefánsson, Kári, Thompson, Paul M., Andreassen, Ole A.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: American Medical Association 2020
• Subjects: imaging; Genetics; Iceland
• Online Access: https://eprints.qut.edu.au/135841/

Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% to 1.0% of the population, making 15q11.2 BP1-BP2 the site of the most prevalent known pathogenic copy number variation (CNV). It is unknown to what extent this CNV influences brain structure and affects cognitive abilities. Objective: To determine the association of the 15q11.2 BP1-BP2 deletion and duplication CNVs with cortical and subcortical brain morphology and cognitive task performance. Design, Setting, and Participants: In this genetic association study, T1-weighted brain magnetic resonance imaging were combined with genetic data from the ENIGMA-CNV consortium and the UK Biobank, with a replication cohort from Iceland. In total, 203 deletion carriers, 45 247 noncarriers, and 306 duplication carriers were included. Data were collected from August 2015 to April 2019, and data were analyzed from September 2018 to September 2019. Main Outcomes and Measures: The associations of the CNV with global and regional measures of surface area and cortical thickness as well as subcortical volumes were investigated, correcting for age, age 2 , sex, scanner, and intracranial volume. Additionally, measures of cognitive ability were analyzed in the full UK Biobank cohort. Results: Of 45756 included individuals, the mean (SD) age was 55.8 (18.3) years, and 23754 (51.9%) were female. Compared with noncarriers, deletion carriers had a lower surface area (Cohen d = -0.41; SE, 0.08; P = 4.9 × 10 -8 ), thicker cortex (Cohen d = 0.36; SE, 0.07; P = 1.3 × 10 -7 ), and a smaller nucleus accumbens (Cohen d = -0.27; SE, 0.07; P = 7.3 × 10 -5 ). There was also a significant negative dose response on cortical thickness (β = -0.24; SE, 0.05; P = 6.8 × 10 -7 ). Regional cortical analyses showed a localization of the effects to the frontal, cingulate, and parietal lobes. Further, cognitive ability was lower for deletion ...