Differential effectiveness of berry polyphenols as anti-giardial agents
Following previous work on the anti-giardial effect of blueberry polyphenols, a range of polyphenol-rich extracts from berries and other fruits was screened for their ability to kill Giardia duodenalis, an intestinal parasite of humans. Polyphenol-rich extracts were prepared from berries using solid...
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Cambridge University Press
2011
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ftqueenmu:oai:eresearch.qmu.ac.uk:20.500.12289/2550 2023-05-15T15:09:46+02:00 Differential effectiveness of berry polyphenols as anti-giardial agents Anthony, J. P. Fyfe, Lorna Stewart, D. McDougall, G. J. 2011-08 1110-1116 application/pdf https://eresearch.qmu.ac.uk/handle/20.500.12289/2550 https://hdl.handle.net/20.500.12289/2550 https://doi.org/10.1017/S0031182011000825 http://10.1017/S0031182011000825 unknown Cambridge University Press Parasitology ER2550 Anthony, J., Fyfe, L., Stewart, D. & McDougall, G. (2011) Differential effectiveness of berry polyphenols as anti-giardial agents, Parasitology, vol. 138, , pp. 1110-1116, 311820 http://dx.doi.org/10.1017/S0031182011000825 https://eresearch.qmu.ac.uk/handle/20.500.12289/2550 http://10.1017/S0031182011000825 article 2011 ftqueenmu https://doi.org/20.500.12289/2550 https://doi.org/10.1017/S0031182011000825 2022-05-15T05:17:05Z Following previous work on the anti-giardial effect of blueberry polyphenols, a range of polyphenol-rich extracts from berries and other fruits was screened for their ability to kill Giardia duodenalis, an intestinal parasite of humans. Polyphenol-rich extracts were prepared from berries using solid-phase extraction and applied to trophozoites of Giardia duodenalis grown in vitro. All berry extracts caused inhibition at 166 _g gallic acid equivalents (GAE)/ml phenol content but extracts from strawberry, arctic bramble, blackberry and cloudberry were as effective as the currently used drug, metronidazole, causing complete trophozoite mortality in vitro. Cloudberry extracts were found to be the most effective causing effectively complete trophozoite mortality at 66 _g GAE/ml. The polyphenol composition of the more effective berry extracts suggested that the presence of ellagitannins could be an important factor. However, the potency of cloudberry could be related to high ellagitannin content but also to the presence of substantial amounts of unconjugated p-coumaric acid and benzoic acid. These in vitro effects occur at concentrations easily achievable in the gut after berry ingestion and we discuss the likelihood that berry extracts could be effective anti-giardial agents in vivo. 2011 Cambridge University Press. The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence . The written permission of Cambridge University Press must be obtained for commercial re-use. sch_die 138 pub 2550 pub 9 Article in Journal/Newspaper Arctic Queen Margaret University Edinburgh: eResearch Arctic Parasitology 138 9 1110 1116 |
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Open Polar |
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Queen Margaret University Edinburgh: eResearch |
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ftqueenmu |
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unknown |
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Following previous work on the anti-giardial effect of blueberry polyphenols, a range of polyphenol-rich extracts from berries and other fruits was screened for their ability to kill Giardia duodenalis, an intestinal parasite of humans. Polyphenol-rich extracts were prepared from berries using solid-phase extraction and applied to trophozoites of Giardia duodenalis grown in vitro. All berry extracts caused inhibition at 166 _g gallic acid equivalents (GAE)/ml phenol content but extracts from strawberry, arctic bramble, blackberry and cloudberry were as effective as the currently used drug, metronidazole, causing complete trophozoite mortality in vitro. Cloudberry extracts were found to be the most effective causing effectively complete trophozoite mortality at 66 _g GAE/ml. The polyphenol composition of the more effective berry extracts suggested that the presence of ellagitannins could be an important factor. However, the potency of cloudberry could be related to high ellagitannin content but also to the presence of substantial amounts of unconjugated p-coumaric acid and benzoic acid. These in vitro effects occur at concentrations easily achievable in the gut after berry ingestion and we discuss the likelihood that berry extracts could be effective anti-giardial agents in vivo. 2011 Cambridge University Press. The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence . The written permission of Cambridge University Press must be obtained for commercial re-use. sch_die 138 pub 2550 pub 9 |
format |
Article in Journal/Newspaper |
author |
Anthony, J. P. Fyfe, Lorna Stewart, D. McDougall, G. J. |
spellingShingle |
Anthony, J. P. Fyfe, Lorna Stewart, D. McDougall, G. J. Differential effectiveness of berry polyphenols as anti-giardial agents |
author_facet |
Anthony, J. P. Fyfe, Lorna Stewart, D. McDougall, G. J. |
author_sort |
Anthony, J. P. |
title |
Differential effectiveness of berry polyphenols as anti-giardial agents |
title_short |
Differential effectiveness of berry polyphenols as anti-giardial agents |
title_full |
Differential effectiveness of berry polyphenols as anti-giardial agents |
title_fullStr |
Differential effectiveness of berry polyphenols as anti-giardial agents |
title_full_unstemmed |
Differential effectiveness of berry polyphenols as anti-giardial agents |
title_sort |
differential effectiveness of berry polyphenols as anti-giardial agents |
publisher |
Cambridge University Press |
publishDate |
2011 |
url |
https://eresearch.qmu.ac.uk/handle/20.500.12289/2550 https://hdl.handle.net/20.500.12289/2550 https://doi.org/10.1017/S0031182011000825 http://10.1017/S0031182011000825 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
Parasitology ER2550 Anthony, J., Fyfe, L., Stewart, D. & McDougall, G. (2011) Differential effectiveness of berry polyphenols as anti-giardial agents, Parasitology, vol. 138, , pp. 1110-1116, 311820 http://dx.doi.org/10.1017/S0031182011000825 https://eresearch.qmu.ac.uk/handle/20.500.12289/2550 http://10.1017/S0031182011000825 |
op_doi |
https://doi.org/20.500.12289/2550 https://doi.org/10.1017/S0031182011000825 |
container_title |
Parasitology |
container_volume |
138 |
container_issue |
9 |
container_start_page |
1110 |
op_container_end_page |
1116 |
_version_ |
1766340885380857856 |