Positive selection and inactivation in the vision and hearing genes of cetaceans.
The transition to an aquatic lifestyle in cetaceans (whales and dolphins) resulted in a radical transformation in their sensory systems. Toothed whales acquired specialized high-frequency hearing tied to the evolution of echolocation, while baleen whales evolved low-frequency hearing. More generally...
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Oxford University Press
2020
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Online Access: | https://qmro.qmul.ac.uk/xmlui/handle/123456789/64101 https://doi.org/10.1093/molbev/msaa070 |
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ftqueenmaryuniv:oai:qmro.qmul.ac.uk:123456789/64101 2023-05-15T15:37:11+02:00 Positive selection and inactivation in the vision and hearing genes of cetaceans. McGowen, MR Tsagkogeorga, G Williamson, J Morin, PA Rossiter, SJ 2020-03-14 https://qmro.qmul.ac.uk/xmlui/handle/123456789/64101 https://doi.org/10.1093/molbev/msaa070 eng eng Oxford University Press Mol Biol Evol McGowen, Michael R et al. "Positive Selection And Inactivation In The Vision And Hearing Genes Of Cetaceans". Molecular Biology And Evolution, 2020. Oxford University Press (OUP), doi:10.1093/molbev/msaa070. Accessed 15 May 2020. https://qmro.qmul.ac.uk/xmlui/handle/123456789/64101 doi:10.1093/molbev/msaa070 This is a pre-copyedited, author-produced version of an article accepted for publication in Molecular Biology and Evolution following peer review. The version of record is available https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msaa070/5805393?redirectedFrom=fulltext © 2020 Oxford University Press Article 2020 ftqueenmaryuniv https://doi.org/10.1093/molbev/msaa070 2022-09-25T20:19:22Z The transition to an aquatic lifestyle in cetaceans (whales and dolphins) resulted in a radical transformation in their sensory systems. Toothed whales acquired specialized high-frequency hearing tied to the evolution of echolocation, while baleen whales evolved low-frequency hearing. More generally, all cetaceans show adaptations for hearing and seeing underwater. To determine the extent to which these phenotypic changes have been driven by molecular adaptation, we performed large-scale targeted sequence capture of 179 sensory genes across the Cetacea, incorporating up to 54 cetacean species from all major clades as well as their closest relatives, the hippopotamuses. We screened for positive selection in 167 loci related to vision and hearing, and found that the diversification of cetaceans has been accompanied by pervasive molecular adaptations in both sets of genes, including several loci implicated in non-syndromic hearing loss (NSHL). Despite these findings, however, we found no direct evidence of positive selection at the base of odontocetes coinciding with the origin of echolocation, as found in studies examining fewer taxa. By using contingency tables incorporating taxon- and gene-based controls, we show that, while numbers of positively selected hearing and NSHL genes are disproportionately high in cetaceans, counts of vision genes do not differ significantly from expected values. Alongside these adaptive changes, we find increased evidence of pseudogenization of genes involved in cone-mediated vision in mysticetes and deep diving odontocetes. Article in Journal/Newspaper baleen whales toothed whales Queen Mary University of London: Queen Mary Research Online (QMRO) Molecular Biology and Evolution 37 7 2069 2083 |
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Open Polar |
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Queen Mary University of London: Queen Mary Research Online (QMRO) |
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ftqueenmaryuniv |
language |
English |
description |
The transition to an aquatic lifestyle in cetaceans (whales and dolphins) resulted in a radical transformation in their sensory systems. Toothed whales acquired specialized high-frequency hearing tied to the evolution of echolocation, while baleen whales evolved low-frequency hearing. More generally, all cetaceans show adaptations for hearing and seeing underwater. To determine the extent to which these phenotypic changes have been driven by molecular adaptation, we performed large-scale targeted sequence capture of 179 sensory genes across the Cetacea, incorporating up to 54 cetacean species from all major clades as well as their closest relatives, the hippopotamuses. We screened for positive selection in 167 loci related to vision and hearing, and found that the diversification of cetaceans has been accompanied by pervasive molecular adaptations in both sets of genes, including several loci implicated in non-syndromic hearing loss (NSHL). Despite these findings, however, we found no direct evidence of positive selection at the base of odontocetes coinciding with the origin of echolocation, as found in studies examining fewer taxa. By using contingency tables incorporating taxon- and gene-based controls, we show that, while numbers of positively selected hearing and NSHL genes are disproportionately high in cetaceans, counts of vision genes do not differ significantly from expected values. Alongside these adaptive changes, we find increased evidence of pseudogenization of genes involved in cone-mediated vision in mysticetes and deep diving odontocetes. |
format |
Article in Journal/Newspaper |
author |
McGowen, MR Tsagkogeorga, G Williamson, J Morin, PA Rossiter, SJ |
spellingShingle |
McGowen, MR Tsagkogeorga, G Williamson, J Morin, PA Rossiter, SJ Positive selection and inactivation in the vision and hearing genes of cetaceans. |
author_facet |
McGowen, MR Tsagkogeorga, G Williamson, J Morin, PA Rossiter, SJ |
author_sort |
McGowen, MR |
title |
Positive selection and inactivation in the vision and hearing genes of cetaceans. |
title_short |
Positive selection and inactivation in the vision and hearing genes of cetaceans. |
title_full |
Positive selection and inactivation in the vision and hearing genes of cetaceans. |
title_fullStr |
Positive selection and inactivation in the vision and hearing genes of cetaceans. |
title_full_unstemmed |
Positive selection and inactivation in the vision and hearing genes of cetaceans. |
title_sort |
positive selection and inactivation in the vision and hearing genes of cetaceans. |
publisher |
Oxford University Press |
publishDate |
2020 |
url |
https://qmro.qmul.ac.uk/xmlui/handle/123456789/64101 https://doi.org/10.1093/molbev/msaa070 |
genre |
baleen whales toothed whales |
genre_facet |
baleen whales toothed whales |
op_relation |
Mol Biol Evol McGowen, Michael R et al. "Positive Selection And Inactivation In The Vision And Hearing Genes Of Cetaceans". Molecular Biology And Evolution, 2020. Oxford University Press (OUP), doi:10.1093/molbev/msaa070. Accessed 15 May 2020. https://qmro.qmul.ac.uk/xmlui/handle/123456789/64101 doi:10.1093/molbev/msaa070 |
op_rights |
This is a pre-copyedited, author-produced version of an article accepted for publication in Molecular Biology and Evolution following peer review. The version of record is available https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msaa070/5805393?redirectedFrom=fulltext © 2020 Oxford University Press |
op_doi |
https://doi.org/10.1093/molbev/msaa070 |
container_title |
Molecular Biology and Evolution |
container_volume |
37 |
container_issue |
7 |
container_start_page |
2069 |
op_container_end_page |
2083 |
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1766367654555156480 |