Repositioning of the global epicentre of non-optimal cholesterol
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct...
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Nature Research
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Cardiovascular diseases Risk factors |
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Cardiovascular diseases Risk factors Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant Nordestgaard, Børge G. Zhao, Dong Aadahl, Mette Abarca-Gómez, Leandra Rahim, Hanan Abdul Abu-Rmeileh, Niveen M. Acosta-Cazares, Benjamin Adams, Robert J. Agdeppa, Imelda A. Aghazadeh-Attari, Javad Aguilar-Salinas, Carlos A. Agyemang, Charles Ahluwalia, Tarunveer S. Ahmad, Noor Ani Ahmadi, Ali Ahmadi, Naser Ahmed, Soheir H. Ahrens, Wolfgang Ajlouni, Kamel Alarouj, Monira AlBuhairan, Fadia AlDhukair, Shahla Ali, Mohamed M. Alkandari, Abdullah Alkerwi, Ala’a Aly, Eman Amarapurkar, Deepak N. Amouyel, Philippe Andersen, Lars Bo Anderssen, Sigmund A. Anjana, Ranjit Mohan Ansari-Moghaddam, Alireza Aounallah-Skhiri, Hajer Araújo, Joana Ariansen, Inger Aris, Tahir Arku, Raphael E. Arlappa, Nimmathota Aryal, Krishna K. Aspelund, Thor Assunção, Maria Cecília F. Auvinen, Juha Avdicová, Mária Azevedo, Ana Azizi, Fereidoun Azmin, Mehrdad Balakrishna, Nagalla Bamoshmoosh, Mohamed Banach, Maciej Bandosz, Piotr Banegas, José R. Barbagallo, Carlo M. Barceló, Alberto Barkat, Amina Bata, Iqbal Batieha, Anwar M. Batyrbek, Assembekov Baur, Louise A. Beaglehole, Robert Belavendra, Antonisamy Ben Romdhane, Habiba Benet, Mikhail Benn, Marianne Berkinbayev, Salim Bernabe-Ortiz, Antonio Bernotiene, Gailute Bettiol, Heloisa Bhargava, Santosh K. Repositioning of the global epicentre of non-optimal cholesterol |
topic_facet |
Cardiovascular diseases Risk factors |
description |
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment ... |
format |
Article in Journal/Newspaper |
author |
Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant Nordestgaard, Børge G. Zhao, Dong Aadahl, Mette Abarca-Gómez, Leandra Rahim, Hanan Abdul Abu-Rmeileh, Niveen M. Acosta-Cazares, Benjamin Adams, Robert J. Agdeppa, Imelda A. Aghazadeh-Attari, Javad Aguilar-Salinas, Carlos A. Agyemang, Charles Ahluwalia, Tarunveer S. Ahmad, Noor Ani Ahmadi, Ali Ahmadi, Naser Ahmed, Soheir H. Ahrens, Wolfgang Ajlouni, Kamel Alarouj, Monira AlBuhairan, Fadia AlDhukair, Shahla Ali, Mohamed M. Alkandari, Abdullah Alkerwi, Ala’a Aly, Eman Amarapurkar, Deepak N. Amouyel, Philippe Andersen, Lars Bo Anderssen, Sigmund A. Anjana, Ranjit Mohan Ansari-Moghaddam, Alireza Aounallah-Skhiri, Hajer Araújo, Joana Ariansen, Inger Aris, Tahir Arku, Raphael E. Arlappa, Nimmathota Aryal, Krishna K. Aspelund, Thor Assunção, Maria Cecília F. Auvinen, Juha Avdicová, Mária Azevedo, Ana Azizi, Fereidoun Azmin, Mehrdad Balakrishna, Nagalla Bamoshmoosh, Mohamed Banach, Maciej Bandosz, Piotr Banegas, José R. Barbagallo, Carlo M. Barceló, Alberto Barkat, Amina Bata, Iqbal Batieha, Anwar M. Batyrbek, Assembekov Baur, Louise A. Beaglehole, Robert Belavendra, Antonisamy Ben Romdhane, Habiba Benet, Mikhail Benn, Marianne Berkinbayev, Salim Bernabe-Ortiz, Antonio Bernotiene, Gailute Bettiol, Heloisa Bhargava, Santosh K. |
author_facet |
Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant Nordestgaard, Børge G. Zhao, Dong Aadahl, Mette Abarca-Gómez, Leandra Rahim, Hanan Abdul Abu-Rmeileh, Niveen M. Acosta-Cazares, Benjamin Adams, Robert J. Agdeppa, Imelda A. Aghazadeh-Attari, Javad Aguilar-Salinas, Carlos A. Agyemang, Charles Ahluwalia, Tarunveer S. Ahmad, Noor Ani Ahmadi, Ali Ahmadi, Naser Ahmed, Soheir H. Ahrens, Wolfgang Ajlouni, Kamel Alarouj, Monira AlBuhairan, Fadia AlDhukair, Shahla Ali, Mohamed M. Alkandari, Abdullah Alkerwi, Ala’a Aly, Eman Amarapurkar, Deepak N. Amouyel, Philippe Andersen, Lars Bo Anderssen, Sigmund A. Anjana, Ranjit Mohan Ansari-Moghaddam, Alireza Aounallah-Skhiri, Hajer Araújo, Joana Ariansen, Inger Aris, Tahir Arku, Raphael E. Arlappa, Nimmathota Aryal, Krishna K. Aspelund, Thor Assunção, Maria Cecília F. Auvinen, Juha Avdicová, Mária Azevedo, Ana Azizi, Fereidoun Azmin, Mehrdad Balakrishna, Nagalla Bamoshmoosh, Mohamed Banach, Maciej Bandosz, Piotr Banegas, José R. Barbagallo, Carlo M. Barceló, Alberto Barkat, Amina Bata, Iqbal Batieha, Anwar M. Batyrbek, Assembekov Baur, Louise A. Beaglehole, Robert Belavendra, Antonisamy Ben Romdhane, Habiba Benet, Mikhail Benn, Marianne Berkinbayev, Salim Bernabe-Ortiz, Antonio Bernotiene, Gailute Bettiol, Heloisa Bhargava, Santosh K. |
author_sort |
Taddei, Cristina |
title |
Repositioning of the global epicentre of non-optimal cholesterol |
title_short |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full |
Repositioning of the global epicentre of non-optimal cholesterol |
title_fullStr |
Repositioning of the global epicentre of non-optimal cholesterol |
title_full_unstemmed |
Repositioning of the global epicentre of non-optimal cholesterol |
title_sort |
repositioning of the global epicentre of non-optimal cholesterol |
publisher |
Nature Research |
url |
http://hdl.handle.net/10576/46851 https://doi.org/10.1038/s41586-020-2338-1 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085994877&origin=inward |
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Greenland Norway Pacific |
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Greenland Norway Pacific |
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Greenland Iceland |
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Greenland Iceland |
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http://dx.doi.org/10.1038/s41586-020-2338-1 NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the global epicentre of non-optimal cholesterol. Nature 582, 73–77 (2020). https://doi.org/10.1038/s41586-020-2338-1 00280836 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085994877&origin=inward http://hdl.handle.net/10576/46851 73-77 7810 582 |
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https://doi.org/10.1038/s41586-020-2338-1 |
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Nature |
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582 |
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1778525881023594496 |
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ftqataruniv:oai:qspace.qu.edu.qa:10576/46851 2023-10-01T03:56:23+02:00 Repositioning of the global epicentre of non-optimal cholesterol Taddei, Cristina Zhou, Bin Bixby, Honor Carrillo-Larco, Rodrigo M. Danaei, Goodarz Jackson, Rod T. Farzadfar, Farshad Sophiea, Marisa K. Di Cesare, Mariachiara Iurilli, Maria Laura Caminia Martinez, Andrea Rodriguez Asghari, Golaleh Dhana, Klodian Gulayin, Pablo Kakarmath, Sujay Santero, Marilina Voortman, Trudy Riley, Leanne M. Cowan, Melanie J. Savin, Stefan Bennett, James E. Stevens, Gretchen A. Paciorek, Christopher J. Aekplakorn, Wichai Cifkova, Renata Giampaoli, Simona Kengne, Andre Pascal Khang, Young Ho Kuulasmaa, Kari Laxmaiah, Avula Margozzini, Paula Mathur, Prashant Nordestgaard, Børge G. Zhao, Dong Aadahl, Mette Abarca-Gómez, Leandra Rahim, Hanan Abdul Abu-Rmeileh, Niveen M. Acosta-Cazares, Benjamin Adams, Robert J. Agdeppa, Imelda A. Aghazadeh-Attari, Javad Aguilar-Salinas, Carlos A. Agyemang, Charles Ahluwalia, Tarunveer S. Ahmad, Noor Ani Ahmadi, Ali Ahmadi, Naser Ahmed, Soheir H. Ahrens, Wolfgang Ajlouni, Kamel Alarouj, Monira AlBuhairan, Fadia AlDhukair, Shahla Ali, Mohamed M. Alkandari, Abdullah Alkerwi, Ala’a Aly, Eman Amarapurkar, Deepak N. Amouyel, Philippe Andersen, Lars Bo Anderssen, Sigmund A. Anjana, Ranjit Mohan Ansari-Moghaddam, Alireza Aounallah-Skhiri, Hajer Araújo, Joana Ariansen, Inger Aris, Tahir Arku, Raphael E. Arlappa, Nimmathota Aryal, Krishna K. Aspelund, Thor Assunção, Maria Cecília F. Auvinen, Juha Avdicová, Mária Azevedo, Ana Azizi, Fereidoun Azmin, Mehrdad Balakrishna, Nagalla Bamoshmoosh, Mohamed Banach, Maciej Bandosz, Piotr Banegas, José R. Barbagallo, Carlo M. Barceló, Alberto Barkat, Amina Bata, Iqbal Batieha, Anwar M. Batyrbek, Assembekov Baur, Louise A. Beaglehole, Robert Belavendra, Antonisamy Ben Romdhane, Habiba Benet, Mikhail Benn, Marianne Berkinbayev, Salim Bernabe-Ortiz, Antonio Bernotiene, Gailute Bettiol, Heloisa Bhargava, Santosh K. application/pdf http://hdl.handle.net/10576/46851 https://doi.org/10.1038/s41586-020-2338-1 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085994877&origin=inward en eng Nature Research http://dx.doi.org/10.1038/s41586-020-2338-1 NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the global epicentre of non-optimal cholesterol. Nature 582, 73–77 (2020). https://doi.org/10.1038/s41586-020-2338-1 00280836 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085994877&origin=inward http://hdl.handle.net/10576/46851 73-77 7810 582 Cardiovascular diseases Risk factors Article ftqataruniv https://doi.org/10.1038/s41586-020-2338-1 2023-09-05T00:35:38Z High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment ... Article in Journal/Newspaper Greenland Iceland Qatar University: QU Institutional Repository Greenland Norway Pacific Nature 582 7810 73 77 |