Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry
Chemical mass shifts are the result of compound-dependent collisional modification of the ejection delay produced by field faults near the endcap electrode apertures in a quadrupole ion trap operated in the mass selective instability mode. Both dissociative and non-dissociative collisions can occur...
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ftpurdueuniv:oai:docs.lib.purdue.edu:dissertations-5228 2023-07-02T03:33:27+02:00 Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry Peng, Yanan Cooks, R. Graham 2004-01-01T08:00:00Z https://docs.lib.purdue.edu/dissertations/AAI3150816 ENG eng Purdue University https://docs.lib.purdue.edu/dissertations/AAI3150816 Theses and Dissertations Available from ProQuest Analytical chemistry text 2004 ftpurdueuniv 2023-06-12T21:40:50Z Chemical mass shifts are the result of compound-dependent collisional modification of the ejection delay produced by field faults near the endcap electrode apertures in a quadrupole ion trap operated in the mass selective instability mode. Both dissociative and non-dissociative collisions can occur but dissociative collisions make the predominant contribution to the chemical mass shifts. In other words, chemical mass shifts are compound-dependent and compounds which are easier to fragment generally give relatively large chemical mass shifts. The large chemical mass shifts associated with the nitro-aromatic compounds could serve as a diagnostic for identifying this class of compounds in mixtures and a simple method of implementing this test is described based on the effect of non-linear resonance on the chemical mass shifts. The kinetic method provides an alternative to current methods of chiral analysis of amino acids. This mass spectrometry-based chiral analysis technique has been applied successfully to the enantiomeric determination of all pure amino acids of interest, giving accurate quantitative results with a relative standard deviation of less than 3% when tested individually using optimized experimental conditions. A general mass spectrometric procedure was established for chiral analysis of both standard mixtures and permafrost extracts. The approach presented in this thesis therefore serves as a rapid and direct method of enantiomeric quantification of amino acids in a complex mixture using the kinetic method. Text permafrost Purdue University: e-Pubs |
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Purdue University: e-Pubs |
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ftpurdueuniv |
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English |
topic |
Analytical chemistry |
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Analytical chemistry Peng, Yanan Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry |
topic_facet |
Analytical chemistry |
description |
Chemical mass shifts are the result of compound-dependent collisional modification of the ejection delay produced by field faults near the endcap electrode apertures in a quadrupole ion trap operated in the mass selective instability mode. Both dissociative and non-dissociative collisions can occur but dissociative collisions make the predominant contribution to the chemical mass shifts. In other words, chemical mass shifts are compound-dependent and compounds which are easier to fragment generally give relatively large chemical mass shifts. The large chemical mass shifts associated with the nitro-aromatic compounds could serve as a diagnostic for identifying this class of compounds in mixtures and a simple method of implementing this test is described based on the effect of non-linear resonance on the chemical mass shifts. The kinetic method provides an alternative to current methods of chiral analysis of amino acids. This mass spectrometry-based chiral analysis technique has been applied successfully to the enantiomeric determination of all pure amino acids of interest, giving accurate quantitative results with a relative standard deviation of less than 3% when tested individually using optimized experimental conditions. A general mass spectrometric procedure was established for chiral analysis of both standard mixtures and permafrost extracts. The approach presented in this thesis therefore serves as a rapid and direct method of enantiomeric quantification of amino acids in a complex mixture using the kinetic method. |
author2 |
Cooks, R. Graham |
format |
Text |
author |
Peng, Yanan |
author_facet |
Peng, Yanan |
author_sort |
Peng, Yanan |
title |
Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry |
title_short |
Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry |
title_full |
Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry |
title_fullStr |
Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry |
title_full_unstemmed |
Chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using ESI-mass spectrometry |
title_sort |
chemical mass shifts in quadrupole ion traps, miniature cylindrical ion trap and chiral analysis of amino acids using esi-mass spectrometry |
publisher |
Purdue University |
publishDate |
2004 |
url |
https://docs.lib.purdue.edu/dissertations/AAI3150816 |
genre |
permafrost |
genre_facet |
permafrost |
op_source |
Theses and Dissertations Available from ProQuest |
op_relation |
https://docs.lib.purdue.edu/dissertations/AAI3150816 |
_version_ |
1770273408881262592 |