Diet adaptation in dog reflects spread of prehistoric agriculture
Adaptations allowing dogs to thrive on a diet rich in starch, including a significant AMY2B copy number gain, constituted a crucial step in the evolution of the dog from the wolf. It is however not clear whether this change was associated with the initial domestication, or represents a secondary shi...
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ftpubmed:oai:www.ncbi.nlm.nih.gov/pmc:5061917 2023-05-15T15:08:38+02:00 Diet adaptation in dog reflects spread of prehistoric agriculture Arendt, M Cairns, K M Ballard, J W O Savolainen, P Axelsson, E 2016-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061917/ http://www.ncbi.nlm.nih.gov/pubmed/27406651 https://doi.org/10.1038/hdy.2016.48 en eng Nature Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061917/ http://www.ncbi.nlm.nih.gov/pubmed/27406651 http://dx.doi.org/10.1038/hdy.2016.48 Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ CC-BY Original Article Text 2016 ftpubmed https://doi.org/10.1038/hdy.2016.48 2016-11-06T01:20:35Z Adaptations allowing dogs to thrive on a diet rich in starch, including a significant AMY2B copy number gain, constituted a crucial step in the evolution of the dog from the wolf. It is however not clear whether this change was associated with the initial domestication, or represents a secondary shift related to the subsequent development of agriculture. Previous efforts to study this process were based on geographically limited data sets and low-resolution methods, and it is therefore not known to what extent the diet adaptations are universal among dogs and whether there are regional differences associated with alternative human subsistence strategies. Here we use droplet PCR to investigate worldwide AMY2B copy number diversity among indigenous as well as breed dogs and wolves to elucidate how a change in dog diet was associated with the domestication process and subsequent shifts in human subsistence. We find that AMY2B copy numbers are bimodally distributed with high copy numbers (median 2nAMY2B=11) in a majority of dogs but no, or few, duplications (median 2nAMY2B=3) in a small group of dogs originating mostly in Australia and the Arctic. We show that this pattern correlates geographically to the spread of prehistoric agriculture and conclude that the diet change may not have been associated with initial domestication but rather the subsequent development and spread of agriculture to most, but not all regions of the globe. Text Arctic PubMed Central (PMC) Arctic Heredity 117 5 301 306 |
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Original Article Arendt, M Cairns, K M Ballard, J W O Savolainen, P Axelsson, E Diet adaptation in dog reflects spread of prehistoric agriculture |
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Original Article |
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Adaptations allowing dogs to thrive on a diet rich in starch, including a significant AMY2B copy number gain, constituted a crucial step in the evolution of the dog from the wolf. It is however not clear whether this change was associated with the initial domestication, or represents a secondary shift related to the subsequent development of agriculture. Previous efforts to study this process were based on geographically limited data sets and low-resolution methods, and it is therefore not known to what extent the diet adaptations are universal among dogs and whether there are regional differences associated with alternative human subsistence strategies. Here we use droplet PCR to investigate worldwide AMY2B copy number diversity among indigenous as well as breed dogs and wolves to elucidate how a change in dog diet was associated with the domestication process and subsequent shifts in human subsistence. We find that AMY2B copy numbers are bimodally distributed with high copy numbers (median 2nAMY2B=11) in a majority of dogs but no, or few, duplications (median 2nAMY2B=3) in a small group of dogs originating mostly in Australia and the Arctic. We show that this pattern correlates geographically to the spread of prehistoric agriculture and conclude that the diet change may not have been associated with initial domestication but rather the subsequent development and spread of agriculture to most, but not all regions of the globe. |
format |
Text |
author |
Arendt, M Cairns, K M Ballard, J W O Savolainen, P Axelsson, E |
author_facet |
Arendt, M Cairns, K M Ballard, J W O Savolainen, P Axelsson, E |
author_sort |
Arendt, M |
title |
Diet adaptation in dog reflects spread of prehistoric agriculture |
title_short |
Diet adaptation in dog reflects spread of prehistoric agriculture |
title_full |
Diet adaptation in dog reflects spread of prehistoric agriculture |
title_fullStr |
Diet adaptation in dog reflects spread of prehistoric agriculture |
title_full_unstemmed |
Diet adaptation in dog reflects spread of prehistoric agriculture |
title_sort |
diet adaptation in dog reflects spread of prehistoric agriculture |
publisher |
Nature Publishing Group |
publishDate |
2016 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061917/ http://www.ncbi.nlm.nih.gov/pubmed/27406651 https://doi.org/10.1038/hdy.2016.48 |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061917/ http://www.ncbi.nlm.nih.gov/pubmed/27406651 http://dx.doi.org/10.1038/hdy.2016.48 |
op_rights |
Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
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CC-BY |
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https://doi.org/10.1038/hdy.2016.48 |
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