The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study
In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is...
Published in: | International Journal of Circumpolar Health |
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ftpubmed:oai:pubmedcentral.nih.gov:9970217 2023-05-15T15:55:13+02:00 The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study Senftleber, Ninna Karsbæk Skøtt Pedersen, Kristine Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika 2023-02-22 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970217/ https://doi.org/10.1080/22423982.2023.2178067 en eng Taylor & Francis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970217/ http://dx.doi.org/10.1080/22423982.2023.2178067 © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Int J Circumpolar Health Theory and Methods Article Text 2023 ftpubmed https://doi.org/10.1080/22423982.2023.2178067 2023-03-05T02:31:09Z In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656. Text Circumpolar Health Greenland greenlander* greenlandic PubMed Central (PMC) Greenland International Journal of Circumpolar Health 82 1 |
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Open Polar |
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PubMed Central (PMC) |
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ftpubmed |
language |
English |
topic |
Theory and Methods Article |
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Theory and Methods Article Senftleber, Ninna Karsbæk Skøtt Pedersen, Kristine Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
topic_facet |
Theory and Methods Article |
description |
In Greenland, traditional marine foods are increasingly being replaced by sucrose- and starch-rich foods. A knock-out c.273_274delAG variant in the sucrase-isomaltase (SI) gene is relatively common in Greenland, with homozygous carriers being unable to digest sucrose and some starch. The variant is associated with a healthier metabolic phenotype in Greenlanders, which is confirmed by SI-knockout mice. We aim to assess if the healthy phenotype is explained by metabolic and microbial differences and if food and taste preferences differ between SI-genotypes. This paper describes the protocol for a randomised cross-over trial conducted in Greenland in 2022 with two dietary interventions of three days; a traditional meat- and fish-rich diet and a starch-rich Western diet with 11 energy% sucrose. The power calculation showed that 22 homozygous SI-carriers and 22 non-carriers were sufficient to detect a 0.5 mmol/L difference in glycaemic variability (80% power, α=0.05). We enrolled 18 carriers and 20 non-carriers. We examined food preferences at baseline and collected samples before and after each intervention for metabolic, metabolome, and microbiome profiling. Analyses of samples have not been completed yet. The Ethics Committee of Greenland approved the study. Results will be disseminated in international peer-reviewed journals and to the general Greenlandic population. NCT05375656. |
format |
Text |
author |
Senftleber, Ninna Karsbæk Skøtt Pedersen, Kristine Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika |
author_facet |
Senftleber, Ninna Karsbæk Skøtt Pedersen, Kristine Schnoor Jørgensen, Cecilie Pedersen, Hanne Bjerg Christensen, Marie Mathilde Kabel Madsen, Emilie Andersen, Kristine Jørsboe, Emil Gillum, Matthew Paul Frøst, Michael Bom Hansen, Torben Jørgensen, Marit Eika |
author_sort |
Senftleber, Ninna Karsbæk |
title |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_short |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_full |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_fullStr |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_full_unstemmed |
The effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
title_sort |
effect of sucrase-isomaltase deficiency on metabolism, food intake and preferences: protocol for a dietary intervention study |
publisher |
Taylor & Francis |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970217/ https://doi.org/10.1080/22423982.2023.2178067 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Circumpolar Health Greenland greenlander* greenlandic |
genre_facet |
Circumpolar Health Greenland greenlander* greenlandic |
op_source |
Int J Circumpolar Health |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970217/ http://dx.doi.org/10.1080/22423982.2023.2178067 |
op_rights |
© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1080/22423982.2023.2178067 |
container_title |
International Journal of Circumpolar Health |
container_volume |
82 |
container_issue |
1 |
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1766390603284742144 |