Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study
INTRODUCTION: Breast cancer is the most common cancer worldwide and the leading cause of cancer related deaths among women. The high incidence and mortality of breast cancer calls for improved prevention, diagnostics, and treatment, including identification of new prognostic and predictive biomarker...
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ftpubmed:oai:pubmedcentral.nih.gov:9901780 2023-05-15T17:39:24+02:00 Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study Delgado, André Berli Tylden, Eline Sol Lukic, Marko Moi, Line Busund, Lill-Tove Rasmussen Lund, Eiliv Olsen, Karina Standahl 2023-02-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901780/ http://www.ncbi.nlm.nih.gov/pubmed/36745618 https://doi.org/10.1371/journal.pone.0281218 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901780/ http://www.ncbi.nlm.nih.gov/pubmed/36745618 http://dx.doi.org/10.1371/journal.pone.0281218 © 2023 Delgado et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY PLoS One Research Article Text 2023 ftpubmed https://doi.org/10.1371/journal.pone.0281218 2023-02-12T01:54:22Z INTRODUCTION: Breast cancer is the most common cancer worldwide and the leading cause of cancer related deaths among women. The high incidence and mortality of breast cancer calls for improved prevention, diagnostics, and treatment, including identification of new prognostic and predictive biomarkers for use in precision medicine. MATERIAL AND METHODS: With the aim of compiling a cohort amenable to integrative study designs, we collected detailed epidemiological and clinical data, blood samples, and tumor tissue from a subset of participants from the prospective, population-based Norwegian Women and Cancer (NOWAC) study. These study participants were diagnosed with invasive breast cancer in North Norway before 2013 according to the Cancer Registry of Norway and constitute the Clinical and Multi-omic (CAMO) cohort. Prospectively collected questionnaire data on lifestyle and reproductive factors and blood samples were extracted from the NOWAC study, clinical and histopathological data were manually curated from medical records, and archived tumor tissue collected. RESULTS: The lifestyle and reproductive characteristics of the study participants in the CAMO cohort (n = 388) were largely similar to those of the breast cancer patients in NOWAC (n = 10 356). The majority of the cancers in the CAMO cohort were tumor grade 2 and of the luminal A subtype. Approx. 80% were estrogen receptor positive, 13% were HER2 positive, and 12% were triple negative breast cancers. Lymph node metastases were present in 31% at diagnosis. The epidemiological dataset in the CAMO cohort is complemented by mRNA, miRNA, and metabolomics analyses in plasma, as well as miRNA profiling in tumor tissue. Additionally, histological analyses at the level of proteins and miRNAs in tumor tissue are currently ongoing. CONCLUSION: The CAMO cohort provides data suitable for epidemiological, clinical, molecular, and multi-omics investigations, thereby enabling a systems epidemiology approach to translational breast cancer research. Text North Norway PubMed Central (PMC) Norway PLOS ONE 18 2 e0281218 |
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Research Article Delgado, André Berli Tylden, Eline Sol Lukic, Marko Moi, Line Busund, Lill-Tove Rasmussen Lund, Eiliv Olsen, Karina Standahl Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study |
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Research Article |
description |
INTRODUCTION: Breast cancer is the most common cancer worldwide and the leading cause of cancer related deaths among women. The high incidence and mortality of breast cancer calls for improved prevention, diagnostics, and treatment, including identification of new prognostic and predictive biomarkers for use in precision medicine. MATERIAL AND METHODS: With the aim of compiling a cohort amenable to integrative study designs, we collected detailed epidemiological and clinical data, blood samples, and tumor tissue from a subset of participants from the prospective, population-based Norwegian Women and Cancer (NOWAC) study. These study participants were diagnosed with invasive breast cancer in North Norway before 2013 according to the Cancer Registry of Norway and constitute the Clinical and Multi-omic (CAMO) cohort. Prospectively collected questionnaire data on lifestyle and reproductive factors and blood samples were extracted from the NOWAC study, clinical and histopathological data were manually curated from medical records, and archived tumor tissue collected. RESULTS: The lifestyle and reproductive characteristics of the study participants in the CAMO cohort (n = 388) were largely similar to those of the breast cancer patients in NOWAC (n = 10 356). The majority of the cancers in the CAMO cohort were tumor grade 2 and of the luminal A subtype. Approx. 80% were estrogen receptor positive, 13% were HER2 positive, and 12% were triple negative breast cancers. Lymph node metastases were present in 31% at diagnosis. The epidemiological dataset in the CAMO cohort is complemented by mRNA, miRNA, and metabolomics analyses in plasma, as well as miRNA profiling in tumor tissue. Additionally, histological analyses at the level of proteins and miRNAs in tumor tissue are currently ongoing. CONCLUSION: The CAMO cohort provides data suitable for epidemiological, clinical, molecular, and multi-omics investigations, thereby enabling a systems epidemiology approach to translational breast cancer research. |
format |
Text |
author |
Delgado, André Berli Tylden, Eline Sol Lukic, Marko Moi, Line Busund, Lill-Tove Rasmussen Lund, Eiliv Olsen, Karina Standahl |
author_facet |
Delgado, André Berli Tylden, Eline Sol Lukic, Marko Moi, Line Busund, Lill-Tove Rasmussen Lund, Eiliv Olsen, Karina Standahl |
author_sort |
Delgado, André Berli |
title |
Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study |
title_short |
Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study |
title_full |
Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study |
title_fullStr |
Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study |
title_full_unstemmed |
Cohort profile: The Clinical and Multi-omic (CAMO) cohort, part of the Norwegian Women and Cancer (NOWAC) study |
title_sort |
cohort profile: the clinical and multi-omic (camo) cohort, part of the norwegian women and cancer (nowac) study |
publisher |
Public Library of Science |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901780/ http://www.ncbi.nlm.nih.gov/pubmed/36745618 https://doi.org/10.1371/journal.pone.0281218 |
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Norway |
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Norway |
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North Norway |
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North Norway |
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PLoS One |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901780/ http://www.ncbi.nlm.nih.gov/pubmed/36745618 http://dx.doi.org/10.1371/journal.pone.0281218 |
op_rights |
© 2023 Delgado et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0281218 |
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PLOS ONE |
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18 |
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2 |
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e0281218 |
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