Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
BACKGROUND: Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA(1C)) in a n...
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ftpubmed:oai:pubmedcentral.nih.gov:9894408 2023-05-15T18:34:18+02:00 Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study Bekkelund, Svein Ivar 2023-02-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894408/ https://doi.org/10.1371/journal.pone.0281239 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894408/ http://dx.doi.org/10.1371/journal.pone.0281239 © 2023 Svein Ivar Bekkelund https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY PLoS One Research Article Text 2023 ftpubmed https://doi.org/10.1371/journal.pone.0281239 2023-02-05T02:14:29Z BACKGROUND: Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA(1C)) in a nondiabetic general population. METHODS: Associations between CK and the outcome variable HbA(1C) (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA(1C) (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. RESULTS: Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA(1C) (%) in the “high CK” group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the “normal CK” group, P <0.001. CK increased significantly and linearly with higher levels of HbA(1C) (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA(1C) (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA(1C) (%). CONCLUSION: These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. Text Tromsø PubMed Central (PMC) Norway Tromsø PLOS ONE 18 2 e0281239 |
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Research Article Bekkelund, Svein Ivar Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
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Research Article |
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BACKGROUND: Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA(1C)) in a nondiabetic general population. METHODS: Associations between CK and the outcome variable HbA(1C) (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA(1C) (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway. RESULTS: Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA(1C) (%) in the “high CK” group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the “normal CK” group, P <0.001. CK increased significantly and linearly with higher levels of HbA(1C) (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA(1C) (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA(1C) (%). CONCLUSION: These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population. |
format |
Text |
author |
Bekkelund, Svein Ivar |
author_facet |
Bekkelund, Svein Ivar |
author_sort |
Bekkelund, Svein Ivar |
title |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_short |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_full |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_fullStr |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_full_unstemmed |
Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study |
title_sort |
creatine kinase is associated with glycated haemoglobin in a nondiabetic population. the tromsø study |
publisher |
Public Library of Science |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894408/ https://doi.org/10.1371/journal.pone.0281239 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
PLoS One |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894408/ http://dx.doi.org/10.1371/journal.pone.0281239 |
op_rights |
© 2023 Svein Ivar Bekkelund https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0281239 |
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PLOS ONE |
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18 |
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2 |
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e0281239 |
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