Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden
SIMPLE SUMMARY: Infectious pancreatic necrosis virus (IPNV) causes serious disease in salmonid species, especially in fry. In 2016, we identified an IPNV infected sea trout in Lake Vänern in Sweden. Lake Vänern hosts four small populations of landlocked Atlantic salmon and sea trout that each migrat...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861164/ http://www.ncbi.nlm.nih.gov/pubmed/36669059 https://doi.org/10.3390/vetsci10010058 |
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ftpubmed:oai:pubmedcentral.nih.gov:9861164 2023-05-15T15:32:10+02:00 Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden Persson, B. David Schmidt, Jacob Günther Hakhverdyan, Mikhayil Leijon, Mikael Olesen, Niels Jørgen Axén, Charlotte 2023-01-14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861164/ http://www.ncbi.nlm.nih.gov/pubmed/36669059 https://doi.org/10.3390/vetsci10010058 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861164/ http://www.ncbi.nlm.nih.gov/pubmed/36669059 http://dx.doi.org/10.3390/vetsci10010058 © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Vet Sci Article Text 2023 ftpubmed https://doi.org/10.3390/vetsci10010058 2023-01-29T01:44:34Z SIMPLE SUMMARY: Infectious pancreatic necrosis virus (IPNV) causes serious disease in salmonid species, especially in fry. In 2016, we identified an IPNV infected sea trout in Lake Vänern in Sweden. Lake Vänern hosts four small populations of landlocked Atlantic salmon and sea trout that each migrate annually to two different rivers to spawn. The virus was isolated and after sequencing placed it in genogroup 6. The pathogenicity of the virus was investigated in an infection trial in Atlantic salmon, sea trout, and rainbow trout. In the trial, the novel isolate was compared to an isolate of genogroup 5, that usually cause high mortalities. By the end of the trial, the Swedish genogroup 6 isolate only caused mild infection in all three species, suggesting a low pathogenicity. In addition, the prevalence of the virus was monitored by intensified field sampling and PCR analysis from 2016–2020. During this time, the virus was not detected once, thus suggesting a prevalence in the wild of 0.2–0.5%. The low pathogenicity of the local IPNV isolate means that the salmonid populations of fish in Lake Vänern are not immediately threatened. ABSTRACT: In November 2016, infectious pancreatic necrosis virus (IPNV) was isolated from a broodstock female of landlocked sea trout (Salmo trutta) in Lake Vänern in Sweden. VP2 gene sequencing placed the IPNV isolate in genogroup 6, for which pathogenicity is largely unknown. Lake Vänern hosts landlocked sea trout and salmon populations that are endangered, and thus the introduction of new pathogens poses a major threat. In this study we characterized the novel isolate by conducting an infection trial on three salmonid species present in Lake Vänern, whole genome sequencing of the isolate, and prevalence studies in the wild sea trout and salmon in Lake Vänern. During the infection trial, the pathogenicity of the Swedish isolate was compared to that of a pathogenic genogroup 5 isolate. Dead or moribund fish were collected, pooled, and analyzed by cell culture to identify infected ... Text Atlantic salmon PubMed Central (PMC) Veterinary Sciences 10 1 58 |
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Article Persson, B. David Schmidt, Jacob Günther Hakhverdyan, Mikhayil Leijon, Mikael Olesen, Niels Jørgen Axén, Charlotte Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden |
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description |
SIMPLE SUMMARY: Infectious pancreatic necrosis virus (IPNV) causes serious disease in salmonid species, especially in fry. In 2016, we identified an IPNV infected sea trout in Lake Vänern in Sweden. Lake Vänern hosts four small populations of landlocked Atlantic salmon and sea trout that each migrate annually to two different rivers to spawn. The virus was isolated and after sequencing placed it in genogroup 6. The pathogenicity of the virus was investigated in an infection trial in Atlantic salmon, sea trout, and rainbow trout. In the trial, the novel isolate was compared to an isolate of genogroup 5, that usually cause high mortalities. By the end of the trial, the Swedish genogroup 6 isolate only caused mild infection in all three species, suggesting a low pathogenicity. In addition, the prevalence of the virus was monitored by intensified field sampling and PCR analysis from 2016–2020. During this time, the virus was not detected once, thus suggesting a prevalence in the wild of 0.2–0.5%. The low pathogenicity of the local IPNV isolate means that the salmonid populations of fish in Lake Vänern are not immediately threatened. ABSTRACT: In November 2016, infectious pancreatic necrosis virus (IPNV) was isolated from a broodstock female of landlocked sea trout (Salmo trutta) in Lake Vänern in Sweden. VP2 gene sequencing placed the IPNV isolate in genogroup 6, for which pathogenicity is largely unknown. Lake Vänern hosts landlocked sea trout and salmon populations that are endangered, and thus the introduction of new pathogens poses a major threat. In this study we characterized the novel isolate by conducting an infection trial on three salmonid species present in Lake Vänern, whole genome sequencing of the isolate, and prevalence studies in the wild sea trout and salmon in Lake Vänern. During the infection trial, the pathogenicity of the Swedish isolate was compared to that of a pathogenic genogroup 5 isolate. Dead or moribund fish were collected, pooled, and analyzed by cell culture to identify infected ... |
format |
Text |
author |
Persson, B. David Schmidt, Jacob Günther Hakhverdyan, Mikhayil Leijon, Mikael Olesen, Niels Jørgen Axén, Charlotte |
author_facet |
Persson, B. David Schmidt, Jacob Günther Hakhverdyan, Mikhayil Leijon, Mikael Olesen, Niels Jørgen Axén, Charlotte |
author_sort |
Persson, B. David |
title |
Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden |
title_short |
Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden |
title_full |
Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden |
title_fullStr |
Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden |
title_full_unstemmed |
Characterization of a Novel Infectious Pancreatic Necrosis Virus (IPNV) from Genogroup 6 Identified in Sea Trout (Salmo trutta) from Lake Vänern, Sweden |
title_sort |
characterization of a novel infectious pancreatic necrosis virus (ipnv) from genogroup 6 identified in sea trout (salmo trutta) from lake vänern, sweden |
publisher |
MDPI |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861164/ http://www.ncbi.nlm.nih.gov/pubmed/36669059 https://doi.org/10.3390/vetsci10010058 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Vet Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861164/ http://www.ncbi.nlm.nih.gov/pubmed/36669059 http://dx.doi.org/10.3390/vetsci10010058 |
op_rights |
© 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/vetsci10010058 |
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Veterinary Sciences |
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10 |
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58 |
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1766362675575521280 |