Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#

[Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzin...

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Published in:ACS Omega
Main Authors: Xu, Yibo, Wang, Dongyang, Lv, Qianqian, Fu, Peng, Wang, Ying, Zhu, Weiming
Format: Text
Language:English
Published: American Chemical Society 2022
Subjects:
permafrost
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/
https://doi.org/10.1021/acsomega.2c07038
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spelling ftpubmed:oai:pubmedcentral.nih.gov:9835637 2023-05-15T17:57:23+02:00 Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166# Xu, Yibo Wang, Dongyang Lv, Qianqian Fu, Peng Wang, Ying Zhu, Weiming 2022-12-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/ https://doi.org/10.1021/acsomega.2c07038 en eng American Chemical Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/ http://dx.doi.org/10.1021/acsomega.2c07038 © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND CC-BY-NC ACS Omega Text 2022 ftpubmed https://doi.org/10.1021/acsomega.2c07038 2023-01-15T02:08:31Z [Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC(50) values ranging from 8.83 to 10.52 μM. Text permafrost PubMed Central (PMC) ACS Omega 8 1 1542 1547
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
description [Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC(50) values ranging from 8.83 to 10.52 μM.
format Text
author Xu, Yibo
Wang, Dongyang
Lv, Qianqian
Fu, Peng
Wang, Ying
Zhu, Weiming
spellingShingle Xu, Yibo
Wang, Dongyang
Lv, Qianqian
Fu, Peng
Wang, Ying
Zhu, Weiming
Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
author_facet Xu, Yibo
Wang, Dongyang
Lv, Qianqian
Fu, Peng
Wang, Ying
Zhu, Weiming
author_sort Xu, Yibo
title Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_short Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_full Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_fullStr Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_full_unstemmed Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_sort phaeochromycins i–k, three methylene-bridged dimeric polyketides from streptomyces sp. 166#
publisher American Chemical Society
publishDate 2022
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/
https://doi.org/10.1021/acsomega.2c07038
genre permafrost
genre_facet permafrost
op_source ACS Omega
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/
http://dx.doi.org/10.1021/acsomega.2c07038
op_rights © 2022 The Authors. Published by American Chemical Society
https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
op_rightsnorm CC-BY-NC-ND
CC-BY-NC
op_doi https://doi.org/10.1021/acsomega.2c07038
container_title ACS Omega
container_volume 8
container_issue 1
container_start_page 1542
op_container_end_page 1547
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