Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#

[Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzin...

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Bibliographic Details
Published in:ACS Omega
Main Authors: Xu, Yibo, Wang, Dongyang, Lv, Qianqian, Fu, Peng, Wang, Ying, Zhu, Weiming
Format: Text
Language:English
Published: American Chemical Society 2022
Subjects:
permafrost
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/
https://doi.org/10.1021/acsomega.2c07038
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Summary:[Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC(50) values ranging from 8.83 to 10.52 μM.

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