Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is one of the most common hereditary disorders. The population of the Faroe Islands was established by few founders, and genetic drift may have influenced lipid levels. The aim of this study was to describe the lipid distribution by providing a...
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ftpubmed:oai:pubmedcentral.nih.gov:9833255 2023-05-15T16:10:21+02:00 Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database Borg, Sanna á Sørensen Bork, Christian Skjelbo Nielsen, Michael René Berg Schmidt, Erik Kollslíð, Rudi Lundbye-Christensen, Søren Joensen, Albert Marni 2022-03-23 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833255/ https://doi.org/10.1016/j.athplu.2022.03.004 en eng Elsevier http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833255/ http://dx.doi.org/10.1016/j.athplu.2022.03.004 © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND Atheroscler Plus Full Length Article Text 2022 ftpubmed https://doi.org/10.1016/j.athplu.2022.03.004 2023-01-15T02:05:18Z BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is one of the most common hereditary disorders. The population of the Faroe Islands was established by few founders, and genetic drift may have influenced lipid levels. The aim of this study was to describe the lipid distribution by providing age and sex-specific lipid values and to investigate the prevalence of FH in the Faroe Islands. METHODS: We used an electronic nationwide laboratory database that included lipid measurements obtained in the Faroe Islands between January 2006 and September 2020. Percentiles of lipid levels were calculated using quantile regression. The prevalence of FH was estimated according to the Make Early Diagnosis Prevent Early Death (MEDPED) diagnostic criteria and according to the LDL-C cut-off levels included in the Dutch Lipid Clinic Network (DLCN) criteria using generalized linear models with robust variance. RESULTS: According to the MEDPED age-specific cut-offs for LDL-C, a total of 216 subjects met the criteria for definite FH among 30,711 individuals corresponding to a prevalence of 0.70% (1:142). According to the LDL-C cut-offs included in the DLCN criteria, a total of 3,823 (1:8) subjects could be classified as having possible FH, and 10 (1:3,071) subjects could be classified as probable FH corresponding to a prevalence of 12.4% and 0.03%, respectively. Also, we found significant differences in lipid levels according to sex and age groups. CONCLUSION: The Faroe Islands might represent a founder population with a prevalence of possible FH as high as 1 in 8. Further investigation of genetic and clinical characteristics of FH in the Faroe Islands is needed. Text Faroe Islands PubMed Central (PMC) Faroe Islands Atherosclerosis Plus 48 55 59 |
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PubMed Central (PMC) |
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English |
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Full Length Article |
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Full Length Article Borg, Sanna á Sørensen Bork, Christian Skjelbo Nielsen, Michael René Berg Schmidt, Erik Kollslíð, Rudi Lundbye-Christensen, Søren Joensen, Albert Marni Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database |
topic_facet |
Full Length Article |
description |
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is one of the most common hereditary disorders. The population of the Faroe Islands was established by few founders, and genetic drift may have influenced lipid levels. The aim of this study was to describe the lipid distribution by providing age and sex-specific lipid values and to investigate the prevalence of FH in the Faroe Islands. METHODS: We used an electronic nationwide laboratory database that included lipid measurements obtained in the Faroe Islands between January 2006 and September 2020. Percentiles of lipid levels were calculated using quantile regression. The prevalence of FH was estimated according to the Make Early Diagnosis Prevent Early Death (MEDPED) diagnostic criteria and according to the LDL-C cut-off levels included in the Dutch Lipid Clinic Network (DLCN) criteria using generalized linear models with robust variance. RESULTS: According to the MEDPED age-specific cut-offs for LDL-C, a total of 216 subjects met the criteria for definite FH among 30,711 individuals corresponding to a prevalence of 0.70% (1:142). According to the LDL-C cut-offs included in the DLCN criteria, a total of 3,823 (1:8) subjects could be classified as having possible FH, and 10 (1:3,071) subjects could be classified as probable FH corresponding to a prevalence of 12.4% and 0.03%, respectively. Also, we found significant differences in lipid levels according to sex and age groups. CONCLUSION: The Faroe Islands might represent a founder population with a prevalence of possible FH as high as 1 in 8. Further investigation of genetic and clinical characteristics of FH in the Faroe Islands is needed. |
format |
Text |
author |
Borg, Sanna á Sørensen Bork, Christian Skjelbo Nielsen, Michael René Berg Schmidt, Erik Kollslíð, Rudi Lundbye-Christensen, Søren Joensen, Albert Marni |
author_facet |
Borg, Sanna á Sørensen Bork, Christian Skjelbo Nielsen, Michael René Berg Schmidt, Erik Kollslíð, Rudi Lundbye-Christensen, Søren Joensen, Albert Marni |
author_sort |
Borg, Sanna á |
title |
Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database |
title_short |
Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database |
title_full |
Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database |
title_fullStr |
Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database |
title_full_unstemmed |
Lipids, lipoproteins and prevalence of familial hypercholesterolemia in the Faroe Islands – Results from a nationwide laboratory database |
title_sort |
lipids, lipoproteins and prevalence of familial hypercholesterolemia in the faroe islands – results from a nationwide laboratory database |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833255/ https://doi.org/10.1016/j.athplu.2022.03.004 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Atheroscler Plus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833255/ http://dx.doi.org/10.1016/j.athplu.2022.03.004 |
op_rights |
© 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.athplu.2022.03.004 |
container_title |
Atherosclerosis Plus |
container_volume |
48 |
container_start_page |
55 |
op_container_end_page |
59 |
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1765995557774426112 |