Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study
BACKGROUND: Myocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated. AIM: To study the joint effect of MI and ob...
Published in: | Journal of Thrombosis and Haemostasis |
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2022
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796784/ http://www.ncbi.nlm.nih.gov/pubmed/35815348 https://doi.org/10.1111/jth.15812 |
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ftpubmed:oai:pubmedcentral.nih.gov:9796784 2023-05-15T18:34:28+02:00 Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study Sejrup, Joakim K. Tøndel, Birgitte G. Morelli, Vania M. Løchen, Maja‐Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John‐Bjarne Brækkan, Sigrid K. 2022-07-19 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796784/ http://www.ncbi.nlm.nih.gov/pubmed/35815348 https://doi.org/10.1111/jth.15812 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796784/ http://www.ncbi.nlm.nih.gov/pubmed/35815348 http://dx.doi.org/10.1111/jth.15812 © 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. CC-BY-NC J Thromb Haemost THROMBOSIS Text 2022 ftpubmed https://doi.org/10.1111/jth.15812 2023-01-08T01:55:01Z BACKGROUND: Myocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated. AIM: To study the joint effect of MI and obesity on the risk of VTE. METHODS: Study participants (n = 29 410) were recruited from three surveys of the Tromsø Study (conducted in 1994–1995, 2001, and 2007–2008) and followed up through 2014. All incident MI and VTE cases during follow‐up were recorded. Cox regression models with MI as a time‐dependent variable were used to estimate hazard ratios (HRs) of VTE (adjusted for age and sex) by combinations of MI exposure and obesity status. Joint effects were assessed by calculating relative excess risk and attributable proportion (AP) due to interaction. RESULTS: During a median of 19.6 years of follow‐up, 2090 study participants experienced an MI and 784 experienced a VTE. Among those with MI, 55 developed a subsequent VTE, yielding an overall incidence rate (IR) of VTE of 5.3 per 1000 person‐years (95% confidence interval [CI]: 4.1–6.9). In the combined exposure group (MI+/Obesity+), the IR was 11.3 per 1000 person‐years, and the adjusted HR indicated a 3‐fold increased risk of VTE (HR 3.16, 95% CI: 1.99–4.99) compared to the reference group (MI−/Obesity−). The corresponding AP was 0.46 (95% CI: 0.17–0.74). CONCLUSIONS: The combination of MI and obesity yielded a supra‐additive effect on VTE risk of which 46% of the VTE events were attributed to the interaction. Text Tromsø PubMed Central (PMC) Tromsø Journal of Thrombosis and Haemostasis 20 10 2342 2349 |
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THROMBOSIS |
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THROMBOSIS Sejrup, Joakim K. Tøndel, Birgitte G. Morelli, Vania M. Løchen, Maja‐Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John‐Bjarne Brækkan, Sigrid K. Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study |
topic_facet |
THROMBOSIS |
description |
BACKGROUND: Myocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated. AIM: To study the joint effect of MI and obesity on the risk of VTE. METHODS: Study participants (n = 29 410) were recruited from three surveys of the Tromsø Study (conducted in 1994–1995, 2001, and 2007–2008) and followed up through 2014. All incident MI and VTE cases during follow‐up were recorded. Cox regression models with MI as a time‐dependent variable were used to estimate hazard ratios (HRs) of VTE (adjusted for age and sex) by combinations of MI exposure and obesity status. Joint effects were assessed by calculating relative excess risk and attributable proportion (AP) due to interaction. RESULTS: During a median of 19.6 years of follow‐up, 2090 study participants experienced an MI and 784 experienced a VTE. Among those with MI, 55 developed a subsequent VTE, yielding an overall incidence rate (IR) of VTE of 5.3 per 1000 person‐years (95% confidence interval [CI]: 4.1–6.9). In the combined exposure group (MI+/Obesity+), the IR was 11.3 per 1000 person‐years, and the adjusted HR indicated a 3‐fold increased risk of VTE (HR 3.16, 95% CI: 1.99–4.99) compared to the reference group (MI−/Obesity−). The corresponding AP was 0.46 (95% CI: 0.17–0.74). CONCLUSIONS: The combination of MI and obesity yielded a supra‐additive effect on VTE risk of which 46% of the VTE events were attributed to the interaction. |
format |
Text |
author |
Sejrup, Joakim K. Tøndel, Birgitte G. Morelli, Vania M. Løchen, Maja‐Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John‐Bjarne Brækkan, Sigrid K. |
author_facet |
Sejrup, Joakim K. Tøndel, Birgitte G. Morelli, Vania M. Løchen, Maja‐Lisa Njølstad, Inger Mathiesen, Ellisiv B. Wilsgaard, Tom Hansen, John‐Bjarne Brækkan, Sigrid K. |
author_sort |
Sejrup, Joakim K. |
title |
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study |
title_short |
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study |
title_full |
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study |
title_fullStr |
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study |
title_full_unstemmed |
Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study |
title_sort |
joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: the tromsø study |
publisher |
John Wiley and Sons Inc. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796784/ http://www.ncbi.nlm.nih.gov/pubmed/35815348 https://doi.org/10.1111/jth.15812 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
J Thromb Haemost |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796784/ http://www.ncbi.nlm.nih.gov/pubmed/35815348 http://dx.doi.org/10.1111/jth.15812 |
op_rights |
© 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1111/jth.15812 |
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Journal of Thrombosis and Haemostasis |
container_volume |
20 |
container_issue |
10 |
container_start_page |
2342 |
op_container_end_page |
2349 |
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1766219215405056000 |