Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica
The Antarctic continent is one of the most inhospitable places on earth, where living creatures, mostly represented by microorganisms, have specific physiological characteristics that allow them to adapt to the extreme environmental conditions. These physiological adaptations can result in the produ...
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ftpubmed:oai:pubmedcentral.nih.gov:9744802 2023-05-15T13:35:02+02:00 Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica Ordóñez-Enireb, Eunice Cucalón, Roberto V. Cárdenas, Diana Ordóñez, Nadia Coello, Santiago Elizalde, Paola Cárdenas, Washington B. 2022-12-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744802/ http://www.ncbi.nlm.nih.gov/pubmed/36509821 https://doi.org/10.1038/s41598-022-25911-x en eng Nature Publishing Group UK http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744802/ http://www.ncbi.nlm.nih.gov/pubmed/36509821 http://dx.doi.org/10.1038/s41598-022-25911-x © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . CC-BY Sci Rep Article Text 2022 ftpubmed https://doi.org/10.1038/s41598-022-25911-x 2022-12-18T02:05:52Z The Antarctic continent is one of the most inhospitable places on earth, where living creatures, mostly represented by microorganisms, have specific physiological characteristics that allow them to adapt to the extreme environmental conditions. These physiological adaptations can result in the production of unique secondary metabolites with potential biotechnological applications. The current study presents a genetic and antibacterial characterization of four Antarctic fungi isolated from soil samples collected in Pedro Vicente Maldonado Scientific Station, at Fort William Point, Greenwich Island, Antarctica. Based on the sequences of the internal transcribed spacer (ITS) region, the fungi were identified as Antarctomyces sp., Thelebolus sp., Penicillium sp., and Cryptococcus gilvescens. The antibacterial activity was assessed against four clinical bacterial strains: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and Staphylococcus aureus, by a modified bacterial growth inhibition assay on agar plates. Results showed that C. gilvescens and Penicillium sp. have potential antibiotic activity against all bacterial strains. Interestingly, Thelebolus sp. showed potential antibiotic activity only against E. coli. In contrast, Antarctomyces sp. did not show antibiotic activity against any of the bacteria tested under our experimental conditions. This study highlights the importance of conservation of Antarctica as a source of metabolites with important biomedical applications. Text Antarc* Antarctic Antarctica Greenwich Island PubMed Central (PMC) Antarctic Fort William ENVELOPE(-59.725,-59.725,-62.371,-62.371) Greenwich Greenwich Island ENVELOPE(-59.783,-59.783,-62.517,-62.517) The Antarctic Scientific Reports 12 1 |
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Article Ordóñez-Enireb, Eunice Cucalón, Roberto V. Cárdenas, Diana Ordóñez, Nadia Coello, Santiago Elizalde, Paola Cárdenas, Washington B. Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica |
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The Antarctic continent is one of the most inhospitable places on earth, where living creatures, mostly represented by microorganisms, have specific physiological characteristics that allow them to adapt to the extreme environmental conditions. These physiological adaptations can result in the production of unique secondary metabolites with potential biotechnological applications. The current study presents a genetic and antibacterial characterization of four Antarctic fungi isolated from soil samples collected in Pedro Vicente Maldonado Scientific Station, at Fort William Point, Greenwich Island, Antarctica. Based on the sequences of the internal transcribed spacer (ITS) region, the fungi were identified as Antarctomyces sp., Thelebolus sp., Penicillium sp., and Cryptococcus gilvescens. The antibacterial activity was assessed against four clinical bacterial strains: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and Staphylococcus aureus, by a modified bacterial growth inhibition assay on agar plates. Results showed that C. gilvescens and Penicillium sp. have potential antibiotic activity against all bacterial strains. Interestingly, Thelebolus sp. showed potential antibiotic activity only against E. coli. In contrast, Antarctomyces sp. did not show antibiotic activity against any of the bacteria tested under our experimental conditions. This study highlights the importance of conservation of Antarctica as a source of metabolites with important biomedical applications. |
format |
Text |
author |
Ordóñez-Enireb, Eunice Cucalón, Roberto V. Cárdenas, Diana Ordóñez, Nadia Coello, Santiago Elizalde, Paola Cárdenas, Washington B. |
author_facet |
Ordóñez-Enireb, Eunice Cucalón, Roberto V. Cárdenas, Diana Ordóñez, Nadia Coello, Santiago Elizalde, Paola Cárdenas, Washington B. |
author_sort |
Ordóñez-Enireb, Eunice |
title |
Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica |
title_short |
Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica |
title_full |
Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica |
title_fullStr |
Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica |
title_full_unstemmed |
Antarctic fungi with antibiotic potential isolated from Fort William Point, Antarctica |
title_sort |
antarctic fungi with antibiotic potential isolated from fort william point, antarctica |
publisher |
Nature Publishing Group UK |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744802/ http://www.ncbi.nlm.nih.gov/pubmed/36509821 https://doi.org/10.1038/s41598-022-25911-x |
long_lat |
ENVELOPE(-59.725,-59.725,-62.371,-62.371) ENVELOPE(-59.783,-59.783,-62.517,-62.517) |
geographic |
Antarctic Fort William Greenwich Greenwich Island The Antarctic |
geographic_facet |
Antarctic Fort William Greenwich Greenwich Island The Antarctic |
genre |
Antarc* Antarctic Antarctica Greenwich Island |
genre_facet |
Antarc* Antarctic Antarctica Greenwich Island |
op_source |
Sci Rep |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744802/ http://www.ncbi.nlm.nih.gov/pubmed/36509821 http://dx.doi.org/10.1038/s41598-022-25911-x |
op_rights |
© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
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CC-BY |
op_doi |
https://doi.org/10.1038/s41598-022-25911-x |
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Scientific Reports |
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12 |
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1 |
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1766060368512155648 |