How to account for Inuit ancestry in lung function prediction
Rigorous lung function prediction equations for the Inuit are lacking. We used spirometry from 351 Inuit and 29 people of other ancestry obtained during an occupational survey in Greenland to determine how to obtain valid lung function predictions for the Inuit using Global Lung Function Initiative...
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ftpubmed:oai:pubmedcentral.nih.gov:9731580 2023-05-15T15:55:23+02:00 How to account for Inuit ancestry in lung function prediction Laustsen, Birgitte H Bønløkke, Jakob H Miller, Martin R 2022-12-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731580/ http://www.ncbi.nlm.nih.gov/pubmed/36471626 https://doi.org/10.1080/22423982.2022.2151158 en eng Taylor & Francis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731580/ http://www.ncbi.nlm.nih.gov/pubmed/36471626 http://dx.doi.org/10.1080/22423982.2022.2151158 © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY-NC Int J Circumpolar Health Original Research Article Text 2022 ftpubmed https://doi.org/10.1080/22423982.2022.2151158 2022-12-11T02:17:36Z Rigorous lung function prediction equations for the Inuit are lacking. We used spirometry from 351 Inuit and 29 people of other ancestry obtained during an occupational survey in Greenland to determine how to obtain valid lung function predictions for the Inuit using Global Lung Function Initiative (GLI) equations for Europeans. Standing height for the Inuit was used in the predictions as well as their height modified in line with the known differences in standing to sitting height ratio (SHR) for the Inuit. With recorded height in predicting lung function, mean±SD Inuit z-scores for FVC and FEV1 were significantly higher than predicted (0.81±1.20 and 0.53±1.36, respectively, p<0.0001) which was not true for the non-Inuit participants (-0.01±1.04 and 0.15±1.17, respectively). When using height modified for SHR the mean±SD Inuit z-scores for FVC and FEV1 were no longer significantly different from predicted (0.10±1.10 and -0.12±1.24, respectively). The mean±SD Inuit FEV1/FVC z-scores were not significantly different from the non-Inuit, being respectively -0.45±0.98 and -0.01±1.04. Modified height changed the mean±SD Inuit FEV1/FVC z-scores to -0.39±0.99. Representative lung function predictions from GLI equations can be made for Inuit by using standing height modified for the known differences in SHR between Inuit and those of European ancestry Text Circumpolar Health Greenland inuit PubMed Central (PMC) Greenland International Journal of Circumpolar Health 82 1 |
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Original Research Article |
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Original Research Article Laustsen, Birgitte H Bønløkke, Jakob H Miller, Martin R How to account for Inuit ancestry in lung function prediction |
topic_facet |
Original Research Article |
description |
Rigorous lung function prediction equations for the Inuit are lacking. We used spirometry from 351 Inuit and 29 people of other ancestry obtained during an occupational survey in Greenland to determine how to obtain valid lung function predictions for the Inuit using Global Lung Function Initiative (GLI) equations for Europeans. Standing height for the Inuit was used in the predictions as well as their height modified in line with the known differences in standing to sitting height ratio (SHR) for the Inuit. With recorded height in predicting lung function, mean±SD Inuit z-scores for FVC and FEV1 were significantly higher than predicted (0.81±1.20 and 0.53±1.36, respectively, p<0.0001) which was not true for the non-Inuit participants (-0.01±1.04 and 0.15±1.17, respectively). When using height modified for SHR the mean±SD Inuit z-scores for FVC and FEV1 were no longer significantly different from predicted (0.10±1.10 and -0.12±1.24, respectively). The mean±SD Inuit FEV1/FVC z-scores were not significantly different from the non-Inuit, being respectively -0.45±0.98 and -0.01±1.04. Modified height changed the mean±SD Inuit FEV1/FVC z-scores to -0.39±0.99. Representative lung function predictions from GLI equations can be made for Inuit by using standing height modified for the known differences in SHR between Inuit and those of European ancestry |
format |
Text |
author |
Laustsen, Birgitte H Bønløkke, Jakob H Miller, Martin R |
author_facet |
Laustsen, Birgitte H Bønløkke, Jakob H Miller, Martin R |
author_sort |
Laustsen, Birgitte H |
title |
How to account for Inuit ancestry in lung function prediction |
title_short |
How to account for Inuit ancestry in lung function prediction |
title_full |
How to account for Inuit ancestry in lung function prediction |
title_fullStr |
How to account for Inuit ancestry in lung function prediction |
title_full_unstemmed |
How to account for Inuit ancestry in lung function prediction |
title_sort |
how to account for inuit ancestry in lung function prediction |
publisher |
Taylor & Francis |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731580/ http://www.ncbi.nlm.nih.gov/pubmed/36471626 https://doi.org/10.1080/22423982.2022.2151158 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Circumpolar Health Greenland inuit |
genre_facet |
Circumpolar Health Greenland inuit |
op_source |
Int J Circumpolar Health |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731580/ http://www.ncbi.nlm.nih.gov/pubmed/36471626 http://dx.doi.org/10.1080/22423982.2022.2151158 |
op_rights |
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1080/22423982.2022.2151158 |
container_title |
International Journal of Circumpolar Health |
container_volume |
82 |
container_issue |
1 |
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1766390872681742336 |