Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
There is accumulating evidence that interfering with the basic aging mechanisms can enhance healthy longevity. The interventional/therapeutic strategies targeting multiple aging hallmarks could be more effective than targeting one hallmark. While health-promoting qualities of marine oils have been e...
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ftpubmed:oai:pubmedcentral.nih.gov:9699765 2023-05-15T13:33:57+02:00 Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging SenGupta, Tanima Lefol, Yohan Lirussi, Lisa Suaste, Veronica Luders, Torben Gupta, Swapnil Aman, Yahyah Sharma, Kulbhushan Fang, Evandro Fei Nilsen, Hilde 2022-11-09 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699765/ http://www.ncbi.nlm.nih.gov/pubmed/36367773 https://doi.org/10.18632/aging.204375 en eng Impact Journals http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699765/ http://www.ncbi.nlm.nih.gov/pubmed/36367773 http://dx.doi.org/10.18632/aging.204375 Copyright: © 2022 SenGupta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Aging (Albany NY) Research Paper Text 2022 ftpubmed https://doi.org/10.18632/aging.204375 2022-12-04T01:52:34Z There is accumulating evidence that interfering with the basic aging mechanisms can enhance healthy longevity. The interventional/therapeutic strategies targeting multiple aging hallmarks could be more effective than targeting one hallmark. While health-promoting qualities of marine oils have been extensively studied, the underlying molecular mechanisms are not fully understood. Lipid extracts from Antarctic krill are rich in long-chain omega-3 fatty acids choline, and astaxanthin. Here, we used C. elegans and human cells to investigate whether krill oil promotes healthy aging. In a C. elegans model of Parkinson´s disease, we show that krill oil protects dopaminergic neurons from aging-related degeneration, decreases alpha-synuclein aggregation, and improves dopamine-dependent behavior and cognition. Krill oil rewires distinct gene expression programs that contribute to attenuating several aging hallmarks, including oxidative stress, proteotoxic stress, senescence, genomic instability, and mitochondrial dysfunction. Mechanistically, krill oil increases neuronal resilience through temporal transcriptome rewiring to promote anti-oxidative stress and anti-inflammation via healthspan regulating transcription factors such as SNK-1. Moreover, krill oil promotes dopaminergic neuron survival through regulation of synaptic transmission and neuronal functions via PBO-2 and RIM-1. Collectively, krill oil rewires global gene expression programs and promotes healthy aging via abrogating multiple aging hallmarks, suggesting directions for further pre-clinical and clinical explorations. Text Antarc* Antarctic Antarctic Krill PubMed Central (PMC) Antarctic Aging 14 21 8661 8687 |
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Research Paper SenGupta, Tanima Lefol, Yohan Lirussi, Lisa Suaste, Veronica Luders, Torben Gupta, Swapnil Aman, Yahyah Sharma, Kulbhushan Fang, Evandro Fei Nilsen, Hilde Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging |
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Research Paper |
description |
There is accumulating evidence that interfering with the basic aging mechanisms can enhance healthy longevity. The interventional/therapeutic strategies targeting multiple aging hallmarks could be more effective than targeting one hallmark. While health-promoting qualities of marine oils have been extensively studied, the underlying molecular mechanisms are not fully understood. Lipid extracts from Antarctic krill are rich in long-chain omega-3 fatty acids choline, and astaxanthin. Here, we used C. elegans and human cells to investigate whether krill oil promotes healthy aging. In a C. elegans model of Parkinson´s disease, we show that krill oil protects dopaminergic neurons from aging-related degeneration, decreases alpha-synuclein aggregation, and improves dopamine-dependent behavior and cognition. Krill oil rewires distinct gene expression programs that contribute to attenuating several aging hallmarks, including oxidative stress, proteotoxic stress, senescence, genomic instability, and mitochondrial dysfunction. Mechanistically, krill oil increases neuronal resilience through temporal transcriptome rewiring to promote anti-oxidative stress and anti-inflammation via healthspan regulating transcription factors such as SNK-1. Moreover, krill oil promotes dopaminergic neuron survival through regulation of synaptic transmission and neuronal functions via PBO-2 and RIM-1. Collectively, krill oil rewires global gene expression programs and promotes healthy aging via abrogating multiple aging hallmarks, suggesting directions for further pre-clinical and clinical explorations. |
format |
Text |
author |
SenGupta, Tanima Lefol, Yohan Lirussi, Lisa Suaste, Veronica Luders, Torben Gupta, Swapnil Aman, Yahyah Sharma, Kulbhushan Fang, Evandro Fei Nilsen, Hilde |
author_facet |
SenGupta, Tanima Lefol, Yohan Lirussi, Lisa Suaste, Veronica Luders, Torben Gupta, Swapnil Aman, Yahyah Sharma, Kulbhushan Fang, Evandro Fei Nilsen, Hilde |
author_sort |
SenGupta, Tanima |
title |
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging |
title_short |
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging |
title_full |
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging |
title_fullStr |
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging |
title_full_unstemmed |
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging |
title_sort |
krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging |
publisher |
Impact Journals |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699765/ http://www.ncbi.nlm.nih.gov/pubmed/36367773 https://doi.org/10.18632/aging.204375 |
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Antarctic |
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Antarctic |
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Antarc* Antarctic Antarctic Krill |
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Antarc* Antarctic Antarctic Krill |
op_source |
Aging (Albany NY) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699765/ http://www.ncbi.nlm.nih.gov/pubmed/36367773 http://dx.doi.org/10.18632/aging.204375 |
op_rights |
Copyright: © 2022 SenGupta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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CC-BY |
op_doi |
https://doi.org/10.18632/aging.204375 |
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Aging |
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14 |
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21 |
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8661 |
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8687 |
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