Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus)
Accelerating climate change is causing severe habitat fragmentation in the Arctic, threatening the persistence of many cold-adapted species. The Scandinavian arctic fox (Vulpes lagopus) is highly fragmented, with a once continuous, circumpolar distribution, it struggled to recover from a demographic...
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ftpubmed:oai:pubmedcentral.nih.gov:9690288 2023-05-15T14:31:05+02:00 Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus) Cockerill, Christopher A. Hasselgren, Malin Dussex, Nicolas Dalén, Love von Seth, Johanna Angerbjörn, Anders Wallén, Johan F. Landa, Arild Eide, Nina E. Flagstad, Øystein Ehrich, Dorothee Sokolov, Aleksandr Sokolova, Natalya Norén, Karin 2022-11-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690288/ http://www.ncbi.nlm.nih.gov/pubmed/36421799 https://doi.org/10.3390/genes13112124 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690288/ http://www.ncbi.nlm.nih.gov/pubmed/36421799 http://dx.doi.org/10.3390/genes13112124 © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). CC-BY Genes (Basel) Article Text 2022 ftpubmed https://doi.org/10.3390/genes13112124 2022-11-27T02:11:06Z Accelerating climate change is causing severe habitat fragmentation in the Arctic, threatening the persistence of many cold-adapted species. The Scandinavian arctic fox (Vulpes lagopus) is highly fragmented, with a once continuous, circumpolar distribution, it struggled to recover from a demographic bottleneck in the late 19th century. The future persistence of the entire Scandinavian population is highly dependent on the northernmost Fennoscandian subpopulations (Scandinavia and the Kola Peninsula), to provide a link to the viable Siberian population. By analyzing 43 arctic fox genomes, we quantified genomic variation and inbreeding in these populations. Signatures of genome erosion increased from Siberia to northern Sweden indicating a stepping-stone model of connectivity. In northern Fennoscandia, runs of homozygosity (ROH) were on average ~1.47-fold longer than ROH found in Siberia, stretching almost entire scaffolds. Moreover, consistent with recent inbreeding, northern Fennoscandia harbored more homozygous deleterious mutations, whereas Siberia had more in heterozygous state. This study underlines the value of documenting genome erosion following population fragmentation to identify areas requiring conservation priority. With the increasing fragmentation and isolation of Arctic habitats due to global warming, understanding the genomic and demographic consequences is vital for maintaining evolutionary potential and preventing local extinctions. Text Arctic Fox Arctic Climate change Fennoscandia Fennoscandian Global warming kola peninsula Northern Sweden Vulpes lagopus Siberia PubMed Central (PMC) Arctic Kola Peninsula Genes 13 11 2124 |
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PubMed Central (PMC) |
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Article Cockerill, Christopher A. Hasselgren, Malin Dussex, Nicolas Dalén, Love von Seth, Johanna Angerbjörn, Anders Wallén, Johan F. Landa, Arild Eide, Nina E. Flagstad, Øystein Ehrich, Dorothee Sokolov, Aleksandr Sokolova, Natalya Norén, Karin Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus) |
topic_facet |
Article |
description |
Accelerating climate change is causing severe habitat fragmentation in the Arctic, threatening the persistence of many cold-adapted species. The Scandinavian arctic fox (Vulpes lagopus) is highly fragmented, with a once continuous, circumpolar distribution, it struggled to recover from a demographic bottleneck in the late 19th century. The future persistence of the entire Scandinavian population is highly dependent on the northernmost Fennoscandian subpopulations (Scandinavia and the Kola Peninsula), to provide a link to the viable Siberian population. By analyzing 43 arctic fox genomes, we quantified genomic variation and inbreeding in these populations. Signatures of genome erosion increased from Siberia to northern Sweden indicating a stepping-stone model of connectivity. In northern Fennoscandia, runs of homozygosity (ROH) were on average ~1.47-fold longer than ROH found in Siberia, stretching almost entire scaffolds. Moreover, consistent with recent inbreeding, northern Fennoscandia harbored more homozygous deleterious mutations, whereas Siberia had more in heterozygous state. This study underlines the value of documenting genome erosion following population fragmentation to identify areas requiring conservation priority. With the increasing fragmentation and isolation of Arctic habitats due to global warming, understanding the genomic and demographic consequences is vital for maintaining evolutionary potential and preventing local extinctions. |
format |
Text |
author |
Cockerill, Christopher A. Hasselgren, Malin Dussex, Nicolas Dalén, Love von Seth, Johanna Angerbjörn, Anders Wallén, Johan F. Landa, Arild Eide, Nina E. Flagstad, Øystein Ehrich, Dorothee Sokolov, Aleksandr Sokolova, Natalya Norén, Karin |
author_facet |
Cockerill, Christopher A. Hasselgren, Malin Dussex, Nicolas Dalén, Love von Seth, Johanna Angerbjörn, Anders Wallén, Johan F. Landa, Arild Eide, Nina E. Flagstad, Øystein Ehrich, Dorothee Sokolov, Aleksandr Sokolova, Natalya Norén, Karin |
author_sort |
Cockerill, Christopher A. |
title |
Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus) |
title_short |
Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus) |
title_full |
Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus) |
title_fullStr |
Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus) |
title_full_unstemmed |
Genomic Consequences of Fragmentation in the Endangered Fennoscandian Arctic Fox (Vulpes lagopus) |
title_sort |
genomic consequences of fragmentation in the endangered fennoscandian arctic fox (vulpes lagopus) |
publisher |
MDPI |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690288/ http://www.ncbi.nlm.nih.gov/pubmed/36421799 https://doi.org/10.3390/genes13112124 |
geographic |
Arctic Kola Peninsula |
geographic_facet |
Arctic Kola Peninsula |
genre |
Arctic Fox Arctic Climate change Fennoscandia Fennoscandian Global warming kola peninsula Northern Sweden Vulpes lagopus Siberia |
genre_facet |
Arctic Fox Arctic Climate change Fennoscandia Fennoscandian Global warming kola peninsula Northern Sweden Vulpes lagopus Siberia |
op_source |
Genes (Basel) |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9690288/ http://www.ncbi.nlm.nih.gov/pubmed/36421799 http://dx.doi.org/10.3390/genes13112124 |
op_rights |
© 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/genes13112124 |
container_title |
Genes |
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13 |
container_issue |
11 |
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2124 |
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1766304804397645824 |