Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus)
A 14‐year‐old male grey wolf (Canis lupus) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were obse...
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ftpubmed:oai:pubmedcentral.nih.gov:9677352 2023-05-15T15:49:32+02:00 Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok 2022-08-31 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677352/ http://www.ncbi.nlm.nih.gov/pubmed/36043450 https://doi.org/10.1002/vms3.909 en eng John Wiley and Sons Inc. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677352/ http://www.ncbi.nlm.nih.gov/pubmed/36043450 http://dx.doi.org/10.1002/vms3.909 © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. CC-BY Vet Med Sci ZOO ANIMALS Text 2022 ftpubmed https://doi.org/10.1002/vms3.909 2022-11-27T01:44:11Z A 14‐year‐old male grey wolf (Canis lupus) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were observed in the nasal turbinate. Microscopic examination revealed a tumour principally composed of obvious clear tumour cells characterised by small hyperchromatic nuclei and abundant clear cytoplasm. These clear cells were positive for mucin with PAS, PAS‐D reaction, and alcian blue (pH 2.5) staining, but negative for PTAH staining. Immunohistochemically, some of tumour cells were strongly positive for mesenchymal cells (vimentin), whereas they were negative for myoepithelial antigen (alpha‐SMA) and cytokeratin. Based on the histopathological and immunohistochemical features, the present case was diagnosed as high‐grade clear cell variant mucoepidermoid carcinoma (MEC). This is the first description of clear cell variant MEC in a wolf. Text Canis lupus PubMed Central (PMC) Veterinary Medicine and Science 8 6 2678 2682 |
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ZOO ANIMALS Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
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ZOO ANIMALS |
description |
A 14‐year‐old male grey wolf (Canis lupus) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were observed in the nasal turbinate. Microscopic examination revealed a tumour principally composed of obvious clear tumour cells characterised by small hyperchromatic nuclei and abundant clear cytoplasm. These clear cells were positive for mucin with PAS, PAS‐D reaction, and alcian blue (pH 2.5) staining, but negative for PTAH staining. Immunohistochemically, some of tumour cells were strongly positive for mesenchymal cells (vimentin), whereas they were negative for myoepithelial antigen (alpha‐SMA) and cytokeratin. Based on the histopathological and immunohistochemical features, the present case was diagnosed as high‐grade clear cell variant mucoepidermoid carcinoma (MEC). This is the first description of clear cell variant MEC in a wolf. |
format |
Text |
author |
Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok |
author_facet |
Yang, Myeon‐Sik Yun, Hyejin Lee, Ki Chang Lim, Chae Woong Kim, Bumseok |
author_sort |
Yang, Myeon‐Sik |
title |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_short |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_full |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_fullStr |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_full_unstemmed |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_sort |
clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (canis lupus) |
publisher |
John Wiley and Sons Inc. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677352/ http://www.ncbi.nlm.nih.gov/pubmed/36043450 https://doi.org/10.1002/vms3.909 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Vet Med Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677352/ http://www.ncbi.nlm.nih.gov/pubmed/36043450 http://dx.doi.org/10.1002/vms3.909 |
op_rights |
© 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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CC-BY |
op_doi |
https://doi.org/10.1002/vms3.909 |
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Veterinary Medicine and Science |
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6 |
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2678 |
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2682 |
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