Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study
BACKGROUND: Environmental exposures to industrial chemicals, including perfluoroalkyl substances (PFAS), may play a role in bone development and future risk of osteoporosis. However, as prospective evidence is limited, the role of developmental PFAS exposures in bone density changes in childhood is...
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ftpubmed:oai:pubmedcentral.nih.gov:9675242 2023-05-15T16:11:01+02:00 Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study Blomberg, Annelise Mortensen, Jann Weihe, Pál Grandjean, Philippe 2022-11-19 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675242/ http://www.ncbi.nlm.nih.gov/pubmed/36402982 https://doi.org/10.1186/s12940-022-00929-w en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675242/ http://www.ncbi.nlm.nih.gov/pubmed/36402982 http://dx.doi.org/10.1186/s12940-022-00929-w © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. CC0 PDM CC-BY Environ Health Research Text 2022 ftpubmed https://doi.org/10.1186/s12940-022-00929-w 2022-11-27T01:38:49Z BACKGROUND: Environmental exposures to industrial chemicals, including perfluoroalkyl substances (PFAS), may play a role in bone development and future risk of osteoporosis. However, as prospective evidence is limited, the role of developmental PFAS exposures in bone density changes in childhood is unclear. The objective of this study was to estimate associations between serum-PFAS concentrations measured in infancy and early childhood and areal bone mineral density (aBMD) measured at age 9 years in a birth cohort of children from the Faroe Islands. METHODS: We prospectively measured concentrations of five PFAS in cord serum and serum collected at 18 months, 5 years and 9 years, and conducted whole-body DXA scans at the 9-year clinical visit. Our study included 366 mother-child pairs with DXA scans and at least one PFAS measurement. We estimated covariate-adjusted associations of individual PFAS concentrations with age-, sex- and height-adjusted aBMD z-scores using multivariable regression models and applied formal mediation analysis to estimate the possible impact of by several measures of body composition. We also evaluated whether associations were modified by child sex. RESULTS: We found PFAS exposures in childhood to be negatively associated with aBMD z-scores, with the strongest association seen for perfluorononanoic acid (PFNA) at age 5 years. A doubling in age-5 PFNA was associated with a 0.15 decrease in aBMD z-score (95% CI: − 0.26, − 0.039). The PFNA-aBMD association was significantly stronger in males than females, although effect modification by sex was not significant for other PFAS exposures. Results from the mediation analysis suggested that any potential associations between aBMD and 18-month PFAS concentrations may be mediated by total body fat and BMI, although most estimated total effects for PFAS exposures at age 18 months were non-significant. PFAS exposures at age 9 were not associated with age-9 aBMD z-scores. CONCLUSIONS: The PFAS-aBMD associations identified in this and previous studies ... Text Faroe Islands PubMed Central (PMC) Faroe Islands Environmental Health 21 1 |
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Research Blomberg, Annelise Mortensen, Jann Weihe, Pál Grandjean, Philippe Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study |
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Research |
description |
BACKGROUND: Environmental exposures to industrial chemicals, including perfluoroalkyl substances (PFAS), may play a role in bone development and future risk of osteoporosis. However, as prospective evidence is limited, the role of developmental PFAS exposures in bone density changes in childhood is unclear. The objective of this study was to estimate associations between serum-PFAS concentrations measured in infancy and early childhood and areal bone mineral density (aBMD) measured at age 9 years in a birth cohort of children from the Faroe Islands. METHODS: We prospectively measured concentrations of five PFAS in cord serum and serum collected at 18 months, 5 years and 9 years, and conducted whole-body DXA scans at the 9-year clinical visit. Our study included 366 mother-child pairs with DXA scans and at least one PFAS measurement. We estimated covariate-adjusted associations of individual PFAS concentrations with age-, sex- and height-adjusted aBMD z-scores using multivariable regression models and applied formal mediation analysis to estimate the possible impact of by several measures of body composition. We also evaluated whether associations were modified by child sex. RESULTS: We found PFAS exposures in childhood to be negatively associated with aBMD z-scores, with the strongest association seen for perfluorononanoic acid (PFNA) at age 5 years. A doubling in age-5 PFNA was associated with a 0.15 decrease in aBMD z-score (95% CI: − 0.26, − 0.039). The PFNA-aBMD association was significantly stronger in males than females, although effect modification by sex was not significant for other PFAS exposures. Results from the mediation analysis suggested that any potential associations between aBMD and 18-month PFAS concentrations may be mediated by total body fat and BMI, although most estimated total effects for PFAS exposures at age 18 months were non-significant. PFAS exposures at age 9 were not associated with age-9 aBMD z-scores. CONCLUSIONS: The PFAS-aBMD associations identified in this and previous studies ... |
format |
Text |
author |
Blomberg, Annelise Mortensen, Jann Weihe, Pál Grandjean, Philippe |
author_facet |
Blomberg, Annelise Mortensen, Jann Weihe, Pál Grandjean, Philippe |
author_sort |
Blomberg, Annelise |
title |
Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study |
title_short |
Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study |
title_full |
Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study |
title_fullStr |
Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study |
title_full_unstemmed |
Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study |
title_sort |
bone mass density following developmental exposures to perfluoroalkyl substances (pfas): a longitudinal cohort study |
publisher |
BioMed Central |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675242/ http://www.ncbi.nlm.nih.gov/pubmed/36402982 https://doi.org/10.1186/s12940-022-00929-w |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Environ Health |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675242/ http://www.ncbi.nlm.nih.gov/pubmed/36402982 http://dx.doi.org/10.1186/s12940-022-00929-w |
op_rights |
© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://doi.org/10.1186/s12940-022-00929-w |
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Environmental Health |
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21 |
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1 |
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