Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin
Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precip...
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ftpubmed:oai:pubmedcentral.nih.gov:9669575 2023-05-15T15:00:33+02:00 Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin Sarmiento-Vizcaíno, Aida Martín, Jesús Ortiz-López, Francisco Javier Reyes, Fernando García, Luis A. Blanco, Gloria 2022-11-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669575/ https://doi.org/10.3389/fchem.2022.948795 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669575/ http://dx.doi.org/10.3389/fchem.2022.948795 Copyright © 2022 Sarmiento-Vizcaíno, Martín, Ortiz-López, Reyes, García and Blanco. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CC-BY Front Chem Chemistry Text 2022 ftpubmed https://doi.org/10.3389/fchem.2022.948795 2022-11-20T03:03:24Z Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precipitations. Clouds are considered as atmospheric oases for microorganisms and there is a recent paradigm shift whereby atmospheric-derived Actinobacteria emerge as an alternative source for drug discovery. In this context, we studied a total of 18 bioactive Actinobacteria strains, isolated by sampling nine precipitation events with prevailing Northern winds in the Cantabrian Sea coast, Northern Spain. Backward trajectories meteorological analyses indicate that air masses were originated mostly in the Arctic Ocean, and their trajectory to downwind areas involved the Atlantic Ocean and also terrestrial sources from continental Europe, and in some events from Canada, Greenland, Mauritania and Canary Islands. Taxonomic identification of the isolates, by 16S rRNA gene sequencing and phylogenetic analyses, revealed that they are members of three Actinobacteria genera. Fifteen of the isolates are Streptomyces species, thus increasing the number of bioactive species of this genus in the atmosphere to a 6.8% of the total currently validated species. In addition, two of the strains belong to the genus Micromonospora and one to genus Nocardiopsis. These findings reinforce a previous atmospheric dispersal model, extended herein to the genus Micromonospora. Production of bioactive secondary metabolites was screened in ethyl acetate extracts of the strains by LC-UV-MS and a total of 94 secondary metabolites were detected after LC/MS dereplication. Comparative analyses with natural products databases allowed the identification of 69 structurally diverse natural products with contrasted biological activities, mostly as antibiotics and antitumor agents, but also anti-inflammatory, antiviral, antiparasitic, immunosuppressant and ... Text Arctic Arctic Ocean Greenland PubMed Central (PMC) Arctic Arctic Ocean Canada Greenland Frontiers in Chemistry 10 |
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Chemistry Sarmiento-Vizcaíno, Aida Martín, Jesús Ortiz-López, Francisco Javier Reyes, Fernando García, Luis A. Blanco, Gloria Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin |
topic_facet |
Chemistry |
description |
Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precipitations. Clouds are considered as atmospheric oases for microorganisms and there is a recent paradigm shift whereby atmospheric-derived Actinobacteria emerge as an alternative source for drug discovery. In this context, we studied a total of 18 bioactive Actinobacteria strains, isolated by sampling nine precipitation events with prevailing Northern winds in the Cantabrian Sea coast, Northern Spain. Backward trajectories meteorological analyses indicate that air masses were originated mostly in the Arctic Ocean, and their trajectory to downwind areas involved the Atlantic Ocean and also terrestrial sources from continental Europe, and in some events from Canada, Greenland, Mauritania and Canary Islands. Taxonomic identification of the isolates, by 16S rRNA gene sequencing and phylogenetic analyses, revealed that they are members of three Actinobacteria genera. Fifteen of the isolates are Streptomyces species, thus increasing the number of bioactive species of this genus in the atmosphere to a 6.8% of the total currently validated species. In addition, two of the strains belong to the genus Micromonospora and one to genus Nocardiopsis. These findings reinforce a previous atmospheric dispersal model, extended herein to the genus Micromonospora. Production of bioactive secondary metabolites was screened in ethyl acetate extracts of the strains by LC-UV-MS and a total of 94 secondary metabolites were detected after LC/MS dereplication. Comparative analyses with natural products databases allowed the identification of 69 structurally diverse natural products with contrasted biological activities, mostly as antibiotics and antitumor agents, but also anti-inflammatory, antiviral, antiparasitic, immunosuppressant and ... |
format |
Text |
author |
Sarmiento-Vizcaíno, Aida Martín, Jesús Ortiz-López, Francisco Javier Reyes, Fernando García, Luis A. Blanco, Gloria |
author_facet |
Sarmiento-Vizcaíno, Aida Martín, Jesús Ortiz-López, Francisco Javier Reyes, Fernando García, Luis A. Blanco, Gloria |
author_sort |
Sarmiento-Vizcaíno, Aida |
title |
Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin |
title_short |
Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin |
title_full |
Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin |
title_fullStr |
Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin |
title_full_unstemmed |
Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin |
title_sort |
natural products, including a new caboxamycin, from streptomyces and other actinobacteria isolated in spain from storm clouds transported by northern winds of arctic origin |
publisher |
Frontiers Media S.A. |
publishDate |
2022 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669575/ https://doi.org/10.3389/fchem.2022.948795 |
geographic |
Arctic Arctic Ocean Canada Greenland |
geographic_facet |
Arctic Arctic Ocean Canada Greenland |
genre |
Arctic Arctic Ocean Greenland |
genre_facet |
Arctic Arctic Ocean Greenland |
op_source |
Front Chem |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669575/ http://dx.doi.org/10.3389/fchem.2022.948795 |
op_rights |
Copyright © 2022 Sarmiento-Vizcaíno, Martín, Ortiz-López, Reyes, García and Blanco. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fchem.2022.948795 |
container_title |
Frontiers in Chemistry |
container_volume |
10 |
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1766332637211787264 |